Physiological Reflux and Venous Diameter Change in the Proximal Lower Limb Veins During a Standardised Valsalva Manoeuvre

Jeanneret, Christina; Labs, Karl-Heinz; Aschwanden, Markus; Bollinger, A; Hoffmann, Ulrich; Jäger, K

doi:10.1053/ejvs.1998.0797

Cited by 71 publications

(76 citation statements)

References 7 publications

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“…We have studied all our patients with 2D ultrasound, color and spectral Doppler. Although, there are different methods described to elicit and measure the venous reflux, we used the Valsalva maneuver because of ease of performance [6,7].…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Doppler Evaluation of the Pattern of Involvement of Varicose Veins in Indian Patients

et al. 2010

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Doppler evaluation of lower limb veins was performed to evaluate the pattern of involvement of various sites of incompetence in Indian patients with varicose veins. A prospective Doppler study of 100 consecutive limbs in patients who presented with varicose veins to the vascular surgery department of a tertiary care hospital in India. The Clinico-Etiological Anatomical and Pathological (CEAP) classification was applied for assessment. Doppler evaluation of both superficial and deep venous system of the lower limbs was performed. The data of various sites of reflux was analysed to find the patterns of venous involvement in the affected patients. Superficial venous reflux was seen in all the patients. Deep venous reflux was seen in 50% of the lower limbs examined. Doppler is a simple non-invasive test, and is well tolerated by the patients. Deep venous reflux is common in Indian population, though it rarely occurs in isolation, and is usually associated with superficial reflux.

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Section: Discussionmentioning

confidence: 99%

Ultrasound Doppler Evaluation of the Pattern of Involvement of Varicose Veins in Indian Patients

et al. 2010

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“…Indeed, chronic venous disease is strongly influenced by genetic variance. 24,25 This issue was also addressed in an elaborate genetic analysis of 68 large pedigrees that included 80 nuclear families. 26 The authors found an astoundingly strong genetic variance, namely penetrance frequencies between 70% and 92%.…”

Section: Discussionmentioning

confidence: 99%

Heritability of Venous Function in Humans

Brinsuk

Tank

Luft

et al. 2004

ATVB

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Objectives-Venous function contributes to the pathogenesis of thrombophlebitis, venous thrombosis, and possibly to arterial hypertension. Venous disease is presumably heritable; however, the genetic variance of venous function is unknown. Methods and Results-We determined the heritability of venous function in 46 twin pairs (24 monozygotic, age 35Ϯ11 years, 14 men, 34 women; 22 dizygotic, age 30Ϯ8 years, 19 men, 25 women). After a resting phase in the supine position, we determined venous function in both legs by impedance plethysmography. Venous capacity was determined by a standardized protocol. In addition, we obtained venous pressure volume curves by slowly deflating a thigh cuff from 60 to 0 mm Hg. Venous compliance was determined as the steepest part of the venous pressure volume curve. Heritability was estimated using a path modeling approach. Unadjusted heritability was 0.6 (PϽ0.05) for venous capacity and 0.9 (PϽ0.05) for venous compliance. The heritability estimate for venous capacity decreased to 0.3 after adjustment for age, body mass index, and body fat. The heritability estimate for venous compliance remained essentially unchanged after adjustment for sex and age. Key Words: twin study Ⅲ genetics Ⅲ plethysmography Ⅲ venous compliance A pproximately 75% of the circulating blood volume is contained in veins. Therefore, relatively small changes in venous function may have a substantial effect on the cardiovascular system. For example, an increase in venous tone may cause a shift of blood volume from the periphery toward the heart and increase cardiac output. This mechanism may contribute to increased cardiac output in the earlier stages of essential hypertension. 1,2 Venous function becomes particularly important during assumption of upright posture as 500 to 1000 mL are pooled below the diaphragm. 3 Variability in the amount of blood that is pooled during standing influences the propensity to experience orthostatic symptoms. 4 Venous function may also contribute to the pathogenesis of varicose veins, thrombophlebitis, and venous thrombosis. Thus, genes that influence venous function might play an important role in a variety of common cardiovascular ailments. Indeed, Ϸ60% of the variation in the susceptibility to venous thrombosis is related to genetic factors. 5 A positive family history substantially increases the likelihood to suffer from varicose veins, 6 vasovagal syncope, 7 or essential hypertension. However, the research on the genetics of all these conditions has largely neglected the possibility that venous function may be an important intermediate phenotype. The responsiveness of veins to adrenergic stimulation is influenced by genetic factors. 8,9 Yet, the mechanical properties of veins, such as compliance and capacity, may be more relevant to physiological function. The magnitude of the genetic contribution to these measures is not known. We determined the heritability of venous function in a cohort of normal twins. Conclusions-We Methods SubjectsWe investigated the heritability of venous ...

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“…Although, there are different methods described to elicit and measure the venous reflux, we used the Valsalva maneuver because of ease of performance. 6,7 In this study we had observed varicose veins more in male patients in compare to females (43 and 7). In contrast to us Callam MJ et al 2 and Evans CJ et al 9 described a higher prevalence of varicose veins in women in compare to man.…”

Section: Discussionmentioning

confidence: 49%

Clinico-Anatomical and Radiological Correlation of Varicose Veins of Lower Limb – A Cross-sectional Study

Swain¹,

Singh²,

Rautray³

2018

IJCMR

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Physiological Reflux and Venous Diameter Change in the Proximal Lower Limb Veins During a Standardised Valsalva Manoeuvre

Cited by 71 publications

References 7 publications

Ultrasound Doppler Evaluation of the Pattern of Involvement of Varicose Veins in Indian Patients

Ultrasound Doppler Evaluation of the Pattern of Involvement of Varicose Veins in Indian Patients

Heritability of Venous Function in Humans

Clinico-Anatomical and Radiological Correlation of Varicose Veins of Lower Limb – A Cross-sectional Study

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