Physiologically active complexes of hydrazones (review)

Зеленин, K. Н.; Khorseeva, L. A.; Алексеев, В. В.

doi:10.1007/bf00772901

Cited by 18 publications

(10 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the reason we were interested in the equation where two-valued structure parameter I=0/ 1 (0 means the absence of NH-group in the compounds of the type I, otherwise 1, compounds of the type II) could be used at place of P. The best equation obtained with the level of significance 99 % is the following: lgA=12.98(± 2.03) + 1.29(± 0.22)E LUMO + 0.28(± 0.14) I − 2.07(± 0.52)Q ME (2) n = 15; R 2 = 89.98 %; S = 0.207; F = 32.94. From the equation (2) it follows that the presence of NH-group decreases the biological activity insubstantially (which agrees with experimental data from [3−5]). In Table 1 the values of lg A that are calculated from the equations (1) and (2) (lg A predict (1) and lg A predict (2)), and the differences ∆ between experimental (lg A exp ) and calculated values of lg A are given.…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Study of the Relationship between Chemical Structure and Antimicrobial Activity in a Series of Hydrazine-based Coordination Compounds

Dobrova¹,

Димогло

Chumakov³

2011

Arzneimittelforschung

View full text Add to dashboard Cite

The dependence of antimicrobial activity on the structure of compounds is studied in a series of compounds based on hydrazine coordinated with ions of Cu(II), Ni(II) and Pd(II). The study has been carried out by means of the original electron-topological method developed earlier. A molecular fragment has been found that is only characteristic of biologically active compounds. Its spatial and electron parameters have been used for the quantitative assessment of the activity in view. The results obtained can be used for the antimicrobial activity prediction in a series of compounds with similar structures.

show abstract

Section: Discussionsupporting

confidence: 89%

“…It is known that many hydrazine-based organic and coordination compounds demonstrate anti-inflammatory and antimicrobial properties [1,2]. Coordinating an organic compound and metal results in strengthening a biological activity in many cases.…”

Section: Introductionmentioning

confidence: 99%

Study of the Relationship between Chemical Structure and Antimicrobial Activity in a Series of Hydrazine-based Coordination Compounds

Dobrova¹,

Димогло

Chumakov³

2011

Arzneimittelforschung

View full text Add to dashboard Cite

show abstract

“…Aroyl hydrazones and their metal derivatives often possess biological activity and can inhibit enzymatic reactions in the cell [1][2][3][4][5][6]. Edward et al have shown that replacement of the aromatic group by other moieties in some antibiotics improves their antibiotic activity [7].…”

Section: Introductionmentioning

confidence: 99%

Microwave assisted synthesis, spectroscopic and antibacterial studies of bis(cyclopentadienyl)hafnium(IV) derivatives with benzil bis(aroyl hydrazones)

Sinha

Srivastava

Sengupta

et al. 2008

Transition Met Chem

View full text Add to dashboard Cite

The reactions of (g 5 -C 5 H 5 ) 2 HfCl 2 with benzil bis(hydrazones) (LH 2 ), derived from benzil and aromatic acid hydrazides (benzoic, 2-chlorobenzoic, 4-chlorobenzoic, 2-methylbenzoic or 4-methoxybenzoic) have been studied in anhydrous tetrahydrofuran in the presence of n-butylamine by both conventional methods and by microwave heating. Binuclear complexes of type [{(g 5 -C 5 H 5 ) 2 HfCl} 2 (L)] were obtained in both cases. Tentative structural conclusions are drawn for the reaction products based upon analyses, electrical conductance, magnetic moment and spectral (UV-vis, IR, 1 H NMR and 13 C NMR) data. A FAB-mass spectrum of one compound was also recorded to confirm the binuclear structures. Studies were conducted to assess the growth inhibiting potential of the complexes and free ligands against various bacterial strains.

show abstract

“…[1,2] Interest in such studies also has arisen mainly due to structural problems [3] and the tendency of hydrazides to function as antituberculous, antifungal, and antiviral agents in view of their ability to form metal chelates. [4,5] Further, hydrazones can coordinate to transition metals either in the enolic form (I) or in the keto form (II) as shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Investigation of Mixed‐Ligand Transition Metal Complexes of Alkyl Dithiocarbonate and Benzoylhydrazine or Benzoylhydrazone Derivatives

Zidan

2004

Synthesis and Reactivity in Inorganic and Metal-Organic Chemist

View full text Add to dashboard Cite

Mixed-ligand complexes of the types [Ni(Etdtcn)(BH)], [Ni(Budtcn) (BeBH)], and [M(Rdtcn)(salBH)], where M ¼ Co(II), Ni(II), or Cu(II); R ¼ methyl (Me), ethyl (Et), propyl (Prop) or butyl of the dithiocarbonate (Bu); dtcn ¼ dithiocarbonate group; BH ¼ benzoyl-hydrazine anion, BeBH ¼ benzaldehyde benzoylhydrazone anion, and salBH ¼ salicylaldehyde benzoylhydrazone anion have been synthesised. Elemental analyses, molar conductivities, and spectral (IR, UV, and mass) studies have been used to elucidate the structure of the metal complexes. HBH and HBeBH coordinate in the enol form as bidentate ligands forming a square-planar structure around Ni(II). Moreover, the HsalBH ligand 743 ORDER REPRINTS behaves as tridentate anion with all metal ions and an octahedral structure for these complexes is proposed. The three ligands and some of their complexes were screened against three species of bacteria, namely B. cereus (G þve), P. aeruginosa (G 2ve), and S. aureus (G þve) and five types of fungi, A. flavus, A. fumigatus var. albus, A. niger, F. oxysporum or C. tropicum. The HsalBH ligand has shown high activity against bacteria and fungi, probably due to the presence of a hydroxyl group in this ligand.

show abstract

Physiologically active complexes of hydrazones (review)

Cited by 18 publications

References 73 publications

Study of the Relationship between Chemical Structure and Antimicrobial Activity in a Series of Hydrazine-based Coordination Compounds

Study of the Relationship between Chemical Structure and Antimicrobial Activity in a Series of Hydrazine-based Coordination Compounds

Microwave assisted synthesis, spectroscopic and antibacterial studies of bis(cyclopentadienyl)hafnium(IV) derivatives with benzil bis(aroyl hydrazones)

Synthesis and Investigation of Mixed‐Ligand Transition Metal Complexes of Alkyl Dithiocarbonate and Benzoylhydrazine or Benzoylhydrazone Derivatives

Contact Info

Product

Resources

About