Phyto-Nanoparticles in Osteogenesis

Abstract

Phyto-nanoparticles derived from plants are an emerging class of nanomaterials that integrate the versatility of nanotechnology with the therapeutic potential of botanical ingredients. This chapter explores the utility of phyto-nanoparticles in stimulating osteogenesis for applications in bone tissue engineering and regeneration. Plant extracts serve as sustainable nanoparticle building blocks or coatings through green synthesis approaches. Resultant phyto-nanoparticles possess multifunctional capabilities stemming from the bioactive phytochemical components that enable the modulation of osteogenic cells like mesenchymal stem cells and osteoblasts. Diverse phyto-nanoparticles based on green tea, aloe vera, curcumin, and other plant derivatives have demonstrated the ability to enhance osteoblast differentiation, proliferation, and mineralized matrix deposition. Proposed mechanisms encompass direct cell interactions, sustained intracellular delivery of osteogenic drugs, and complementary anti-inflammatory effects. Capitalizing on these osteogenic properties, researchers have designed innovative tissue engineering scaffolds, functionalized bone implants, and developed therapeutic carriers for diseases like osteoporosis using phyto-nanotechnology. Further innovations in fabrication strategies and integration with emerging technologies will realize smarter, personalized plant-based nanosystems to advance bone regeneration capabilities dramatically.