Phyto-phospholipid complexes (phytosomes): A novel strategy to improve the bioavailability of active constituents

Lu, Mengmeng; Qiu, Qiujun; Luo, Xiang; Liu, Xinrong; Sun, Jing; Wang, Cunyang; Lin, Xingchen; Deng, Yihui; Song, Yanzhi

doi:10.1016/j.ajps.2018.05.011

Cited by 192 publications

(141 citation statements)

References 54 publications

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“…In this study, a three-level Box-Behnken design was applied for formulation and optimization of ICA-phytosomes with minimized vesicle size. The independent factors selected in the present study were previously established to influence the phytosomes formulation [30]. The combinations at the center mid points of edges of the design space represent the composition of the experimental runs.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, lipid-based nanoparticles have demonstrated peculiar advantages such as prolonged circulation [27][28][29]. Phytosomes are phyto-phospholipid complexes that are currently studied for many nanomedicine-based therapies [30]. Phytosomes are generally formed by complexation between the phytoconstituent and the polar part of the lipid.…”

Section: Introductionmentioning

confidence: 99%

“…Phytosomes are generally formed by complexation between the phytoconstituent and the polar part of the lipid. This type of interaction leaves the fatty acid chains free, so they can further move to encapsulate the polar portion of the complex forming a lipophilic surface [30]. Thus, phytosomes have the potential to enhance the oral bioavailability of plant-derived bioactives [31].…”

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells

et al. 2020

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Icariin (ICA) is a flavonol glycoside that has pleiotropic pharmacological actions. It has cytotoxic effects against ovarian cancer cells and increases their chemosensitivity to chemotherapeutic drugs. Phytosomes are identified for their potential in drug delivery of cytotoxic agents. Thus, the purpose of this study was to determine the potential enhancement of ICA cytotoxicity activity in OVCAR-3 ovarian cancer cells via its formulation in phytosomes. ICA-phytosomal formulation was optimized using a Box–Behnken design. Particle size, shape, and in vitro drug release were used to characterize the optimized formula. The optimized formulation exhibited enhanced in vitro drug release. ICA-phytosomes exhibited enhanced cytotoxicity against ovarian cancer cells. Cell cycle analysis indicated accumulation of cells challenged with ICA-phytosomes in G2/M and pre-G1 phases. Staining of cells with annexin V indicated significant elevation of percentage cells with early and late apoptosis as well as total cell death. In addition, the formulation significantly disturbed mitochondrial membrane potential and cellular content of caspase 3. In addition, intracellular release of reactive oxygen species (ROS) was enhanced by ICA-phytosomes. In conclusion, phytosome formulation of ICA significantly potentiates its cytotoxic activities against OVCAR-3 cells. This is mediated, at least partly, by enhanced ICA cellular permeation, apoptosis, and ROS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells

et al. 2020

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“…30 Phytosome can easily move from a hydrophilic environment into the lipophilic environment of the cell membrane and then enter the cell. 33 Our data demonstrated that Curs-Phyto exhibited higher association and internalization into the cells compared to that of free curcuminoids, which proved that the phytosomal formulation has a profound impact on the uptake of curcuminoids. Curcuminoids were taken up more efficiently when formulated in phytosome.…”

Section: Cell Cycle Analysissupporting

confidence: 53%

Phytosomal Nanoparticles Preparation of Curcuminoids to Enhance Cellular Uptake of Curcuminoids on Breast Cancer Cell Line MCF-7

Long¹,

Ha²,

Tuan³

et al. 2019

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• A simple and effective evaporation combined extrusion method to prepare curcuminoidsloaded nano phytosome is successfully applied. • The physically stable phytosomal nanoparticles of curcuminoids were formed at a spherical shape with good size (~ 180 nm), a narrow size distribution (PDI < 0.2), high complexation rate (~87%, 95%, and 90% for bisdemethoxycurcumin, demethoxycurcumin, and curcumin, respectively) and high loading capacity of curcuminoids. • The interaction between curcuminoids and phospholipid by a hydrogen bond was confirmed by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), fourier transform infrared (FT-IR), and 1 H nuclear magnetic resonance (1 H-NMR). • Curcuminoids-loaded nano phytosomes showed significantly higher cellular uptake and in vitro cytotoxicity profile on breast cancer cell line compared to raw curcuminoids indicating the potential of phytosomal nanoparticles as a promising delivery system for natural herbal phytoconstituents for anticancer applications.

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“…As illustrated in Table 4, phytosome carrier can also deliver bioactive compounds, both lipophilic and hydrophilic, in order to enhance oral bioavailability (Lu et al, 2018). Phytosomes are a durable complexes, with a simple manufacturing process (Gnananath et al, 2017).…”

Section: Phytosomesmentioning

confidence: 99%

Vesicle properties and health benefits of milk phospholipids: a review

Huang¹,

Zhao²,

Guan³

et al. 2019

Journal of Food Bioactives

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Phospholipids are important ingredients in milk. They serve as bioactive components with processing functionalities, despite representing only a small proportion of total milk lipids. There has been increasing interest in vesicle properties and health effects of milk phospholipids. However, there are limited reports on industry-scale manufacturing of related commercial products. This contribution aims to elucidate the industrial processes of manufacturing milk phospholipid products including phospholipid extraction and fraction as well as summarizing determination assays of milk phospholipids. In addition to industrial production, this review elaborates on application aspects, such as the biological properties of milk phospholipids and their technical importance as delivery vesicles of liposomes and phytosomes. In addition, new insights on large-scale production of milk phospholipids and new applications such as phytosomes and antioxidant properties are discussed.

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Phyto-phospholipid complexes (phytosomes): A novel strategy to improve the bioavailability of active constituents

Cited by 192 publications

References 54 publications

RETRACTED: Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells

RETRACTED: Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells

Phytosomal Nanoparticles Preparation of Curcuminoids to Enhance Cellular Uptake of Curcuminoids on Breast Cancer Cell Line MCF-7

Vesicle properties and health benefits of milk phospholipids: a review

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