Phytochemical Analysis and Anti-arthritic Activity of <i>Ficus carica</i> Leaves

Rajesh, B.; Ramasubbualakshmi, A; Gopalasatheeskumar, K; Bharathi, Divya; Nishanth, Reddy P.

doi:10.5958/0974-4150.2020.00030.9

Cited by 7 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 52 Notably, it was found that several secondary metabolites, such as steroids, triterpenoids, alkaloids, and flavonoids, were responsible for these properties. 52 An increase concentration of the extract resulted in increased percentage inhibition of protein denaturation suggesting a protective mechanism. 52 Another study by Bahadori et al revealed that lupeol, a dietary triterpene found in F. carica also demonstrated anti-arthritic properties, although the mechanism is yet to be fully elucidated.…”

Section: Methodsmentioning

confidence: 99%

“…Many parts of this plant such as the leaves and roots are used to treat various conditions, such as gastrointestinal (colic, indigestion, loss of appetite, and diarrhea), respiratory (sore throat, cough, and bronchial problems), inflammatory, and cardiovascular disorders, as well as antispasmodic. 52 Studies using both in vitro and in vivo models have identified numerous other biological properties such as antioxidant, antimicrobial, anti-neurodegenerative, anti-arthritic, anti-cancer, anti-diabetic and many more. [52][53][54][55][56][57]…”

Section: Phytochemistry Of F Caricamentioning

confidence: 99%

“…52 Studies using both in vitro and in vivo models have identified numerous other biological properties such as antioxidant, antimicrobial, anti-neurodegenerative, anti-arthritic, anti-cancer, anti-diabetic and many more. [52][53][54][55][56][57]…”

Section: Phytochemistry Of F Caricamentioning

confidence: 99%

“…55 A phytochemical analysis of F. carica leaves observed a potent anti-arthritic activity based on in vitro inhibition using a protein denaturation method. 52 Notably, it was found that several secondary metabolites, such as steroids, triterpenoids, alkaloids, and flavonoids, were responsible for these properties. 52 An increase concentration of the extract resulted in increased percentage inhibition of protein denaturation suggesting a protective mechanism.…”

Section: F Surmentioning

confidence: 99%

See 3 more Smart Citations

Physicochemistry, Nutritional, and Therapeutic Potential of Ficus carica – A Promising Nutraceutical

Fazel,

Abu,

Mohamad

et al. 2024

DDDT

View full text Add to dashboard Cite

In an era where synthetic supplements have raised concerns regarding their effects on human health, Ficus carica has emerged as a natural alternative rich in polyphenolic compounds with potent therapeutic properties. Various studies on F. carica focusing on the analysis and validation of its pharmacological and nutritional properties are emerging. This paper summarizes present data and information on the phytochemical, nutritional values, therapeutic potential, as well as the toxicity profile of F. carica . An extensive search was conducted from various databases, including PubMed, ScienceDirect, Scopus, and Google Scholar. A total of 126 studies and articles related to F. carica that were published between 1999 and 2023 were included in this review. Remarkably, F. carica exhibits a diverse array of advantageous effects, including, but not limited to, antioxidant, anti-neurodegenerative, antimicrobial, antiviral, anti-inflammatory, anti-arthritic, antiepileptic, anticonvulsant, anti-hyperlipidemic, anti-angiogenic, antidiabetic, anti-cancer, and antimutagenic properties. Among the highlights include that antioxidants from F. carica were demonstrated to inhibit cholinesterase, potentially protecting neurons in Alzheimer’s disease and other neurodegenerative conditions. The antimicrobial activities of F. carica were attributed to its high flavonoids and terpenoids content, while its virucidal action through the inhibition of DNA and RNA replication was postulated due to its triterpenes content. Inflammatory and arthritic conditions may also benefit from its anti-inflammatory and anti-arthritic properties through the modulation of various signalling proteins. Studies have also shown that F. carica extracts were generally safe and exhibit low toxicity profile, although more research in this aspect is required, specifically its effects on the skin. In conclusion, this study highlights the potential of F. carica as a valuable natural therapeutic agent and dietary supplement. However, continued exploration on F. carica’ s safety and efficacy is still required prior to embarking on clinical trials, as its role in personalized nutrition and medication will open a new paradigm to improve health outcomes.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Phytochemistry Of F Caricamentioning

confidence: 99%

Section: Phytochemistry Of F Caricamentioning

confidence: 99%

Section: F Surmentioning

confidence: 99%

See 2 more Smart Citations

Physicochemistry, Nutritional, and Therapeutic Potential of Ficus carica – A Promising Nutraceutical

Fazel,

Abu,

Mohamad

et al. 2024

DDDT

View full text Add to dashboard Cite

show abstract

Updated review on Indian Ficus species

Singh

Sharma

2023

Arabian Journal of Chemistry

View full text Add to dashboard Cite

Investigation of Immunomodulatory Activity of Methanolic Extract and Isolated Compound of Pavonia odorata Roots in Mice

Singune

Vaghela

2021

RJPT

View full text Add to dashboard Cite

The immune system plays a role in protective mechanism against the foreign and its modulation either suppression or stimulation was implicated in several human diseases like infection, inflammatory and autoimmune diseases, etc. For which several allopathic immunomodulators have been used for treatment, exhibit potential side effects. Biological active compounds from natural sources used in the treatment of an immune-related disorder. Being the importance of natural compound. The present study was undertaken to evaluate the immunomodulatory activity of methanolic roots extract of Pavonia odorata and isolated compounds from Pavonia odorata. Immunomodulatory activities were determined by in vivo models- delayed-type hypersensitivity (DTH), carbon clearance assay (Phagocytic index), and cyclophosphamide-induced immunosuppression. The methanolic extracts of Pavonia odorata and isolated compound, in the concentration range 5, 10, 25, 50 and 100µg were also tested for phagocytic effect on neutrophils using the in vitro models-nitroblue tetrazolium (NBT) dye test. Mice treated with dose i.e. 200mg/kg (Group III) and dose 370mg/kg (Group-IV) increase response in footpad edema was found to be statistically significant (*p˂ 0.05), (**p˂ 0.01) and showed statistically significant (*p˂ 0.05) increase in WBC and platelets count and phagocytic index when compared to cyclophosphamide (20mg/kg) treated and control-treated mice. In cyclophosphamide induces immunosuppression, methanolic roots extract Pavonia odorata and isolated compound showed significant (P < 0.001) increase total differential leucocytes count DLC and hematological parameters RBCs, Hb, Platelets and WBCs significant increases when compared with cyclophosphamide group. Methanolic extract of Pavonia odorata and isolated compound in the concentration range 5, 10, 25, 50 and 100µg also showed significant (p˂ 0.001) phagocytic effect on neutrophils in the parameter studied. The present experimental finding demonstrated that isolated compound has superior immunomodulatory activity then methnolic extract of Pavonia odorata this effect presumably due to the greater ability of isolated compound to boost the innate and adaptive immune system.

show abstract

Phytochemical Analysis and Anti-arthritic Activity of Ficus carica Leaves

Cited by 7 publications

References 0 publications

Physicochemistry, Nutritional, and Therapeutic Potential of Ficus carica – A Promising Nutraceutical

Physicochemistry, Nutritional, and Therapeutic Potential of Ficus carica – A Promising Nutraceutical

Updated review on Indian Ficus species

Investigation of Immunomodulatory Activity of Methanolic Extract and Isolated Compound of Pavonia odorata Roots in Mice

Contact Info

Product

Resources

About