Phytochemical Analysis and Antibacterial Activities of Kyllinga nemoralis Extracts against the Growth of some Pathogenic Bacteria

Wahab, Noor Zarina Abd; Rahman, Amirul Hafizul Aiman Abd

doi:10.22207/jpam.16.4.23

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…The high MIC of the methanol extract of M. malabathricum against S. aureus and C. albicans might be because it lacks steroids. Nonpolar compounds such as steroids and cholesterol have been reported to exert antimicrobial activity by disrupting the permeability and integrity of cell membranes [102,103]. Another study also found that the extracts of some studied plants from virgin lands also had antimicrobial activity.…”

Section: Antibacterial Activity Against S Aureus (American Type Cultu...mentioning

confidence: 91%

Biological potential of eight medicinal plants collected in the restored landscape after mining in South Kalimantan

Wiraswati,

Pradini,

Fauziah

et al. 2024

Discov Appl Sci

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Land restoration is expected to enhance the supply of valuable ecosystem resources such as herbaceous bushes and weeds. This study aimed to determine the primary phytochemical constituents and bioactivities of methanol extracts from eight bushes and weeds collected from a restored post-mining landscape in South Kalimantan, Indonesia. Qualitative phytochemical analysis showed the presence of phenolic compounds, flavonoids, tannins, alkaloids, steroids, terpenoids and saponins in the methanol extracts of herbaceous plants. Their antioxidant activity was measured by using the 2,2-diphenyl-1-picryl-hydrazyl-hydrate assay. Their superoxide dismutase (SOD) activity was also measured. In addition, selected plant extracts were screened against the common human pathogens Staphylococcus aureus and Candida albicans. Phytochemical analysis showed that the methanol extracts contained all the bioactive compounds examined in this study except the one from Lycopodium cernuum, which lacked flavonoids and alkaloids. Further investigation revealed that all methanol extracts except the one from L. cernuum had promising antioxidant potential. The methanol extracts from Chromolaena odorata (stem), Trema micrantha, Melastoma malabathricum (flower and leaf) and Thypa angustifolia exhibited effective antibacterial activity. In addition, the methanol extracts from M. malabathricum (flower and leaf), T. micrantha, Scleria sumatrensis and Breynia cernua (leaf) exhibited effective antifungal activity. M. malabathricum (flower and leaf) has the greatest potential as a herbaceous plant since its methanol extract exhibits the most potent antioxidant, antibacterial and antifungal activities.

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Section: Antibacterial Activity Against S Aureus (American Type Cultu...mentioning

confidence: 91%

Biological potential of eight medicinal plants collected in the restored landscape after mining in South Kalimantan

Wiraswati,

Pradini,

Fauziah

et al. 2024

Discov Appl Sci

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“…sonnei, S. typhi and K. pneumoniae. 44 Punitha et al 45 experimented with the peel of bitter orange (Citrus aurantium), lemon (Citrus medica) and tree apple (Limonia acidissima) fruits and found alkaloids, steroids, saponins, flavonoids, tannins, terpenes, phenolic substances and cardiac glycosides in their composition. The team of authors found that C. aurantium peel extract showed higher antimicrobial activity against S. aureus, S. epidermis, P. aeruginosa, K. pneumoniae, C. albicans, and A. niger with a different zone of growth inhibition.…”

Section: Inedible Plantsmentioning

confidence: 99%

Antimicrobial activity of saponin-containing plants: review

Alina,

Kiełb Ewa,

František

2023

JDVAR

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The resistance of pathogenic microorganisms to antibiotics has become a "scourge" of the medical field in recent decades. In this regard, the vector of medical research rightly changed in favor of the search for natural mechanisms to fight pathogens. Nature has produced mechanisms for maintaining balance for millions of years, so it is reasonable to investigate and, in the future, use such mechanisms. This current study reviews and analyzes the last five years of research on the effects of saponin-containing plants on the most common pathogens. The analysis of literary data confirms the growing interest in natural antimicrobial drugs that are currently used in folk medicine or have the prospect of use in humane medicine in different countries of the world. Wide interest of the scientific community in the search for alternative antimicrobial agents, which would make it possible to overcome antibiotic resistance in the treatment of various types of diseases, has been revealed. Current scientific research has confirmed or disproved the effectiveness of only a thousandth part of all possible plants. Undoubtedly, the use of natural plant components will make it possible to make the treatment process cheaper and more effective, so this direction of research is currently very promising from all points of view.

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“…This effect can react with free radicals such as DPPH, superoxide radicals, hydroxyl radicals, and hydrogen peroxide radicals. Besides that, the presence of saponin, terpenoid, and steroids in the plant extract may be responsible for its radical scavenging capacity and antimicrobial action towards Staphylococcus aureus and multidrugresistant S. aureus [9]. This work aims to evaluate the potential effect of K. nemoralis leaves and stems extract against HSV-1 replication in vitro.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cytotoxicity and antiviral activity of Kyllinga nemoralis leaves and stems methanolic extract

Abd Wahab,

Mohd Saidi,

Rahman

et al. 2024

J App Biol Biotech

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This present study aimed to investigate the potential stems and leaves methanolic extract of Kyllinga nemoralis as an antiviral agent against Herpes Simplex Virus Type 1 (HSV-1). The leaves and stems of K. nemoralis methanolic extract were assessed in the cytotoxicity test using the MTT assays. The plaque reduction assay was evaluated in the post-treatment assay, pre-treatment assay, virucidal assay, time-addition test, and time-removal test. Cytotoxicity screening of stems and leaves of K. nemoralis against Vero cells shows that the cytotoxicity concentration of 50% of cell viability (CC50) values was 0.75 mg/mL, which indicates that K. nemoralis is non-cytotoxic and safe. The antiviral assay provides a Selective Index (SI) value (CC50/EC50) to determine the good SI for antiviral activity. In post-treatment, the SI value for this extract against HSV-1 was 8.33. In pre-treatment, the SI value for this extract was 21.43. In the virucidal test, the SI value for this extract was 24.19 mg/mL. In the time addition assay, the plaque inhibition reached 43% when the extract was added at 2 h.p.i, and it dropped to 15% at 10 h.p.i. In the time removal assay, the plaque inhibition reached 50% after the extract was removed at 2 h.p.i., and it increased to 87% at 24 h.p.i. This study showed that K. nemoralis has potential as a drug used to fight herpes infections.

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Phytochemical Analysis and Antibacterial Activities of Kyllinga nemoralis Extracts against the Growth of some Pathogenic Bacteria

Cited by 4 publications

References 35 publications

Biological potential of eight medicinal plants collected in the restored landscape after mining in South Kalimantan

Biological potential of eight medicinal plants collected in the restored landscape after mining in South Kalimantan

Antimicrobial activity of saponin-containing plants: review

Evaluation of cytotoxicity and antiviral activity of Kyllinga nemoralis leaves and stems methanolic extract

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