Phytochemical Analysis and Antidiabetic Potential of Armoracia Rusticana: Pharmacological and Computational Approach

Abstract

Aims & Objective: Armoracia Rusticana has high medicinal values and is an excellent source of phytochemicals. This study was aimed to evaluate the antidiabetic potential of bioactive compounds from Armoracia Rusticana. Methods: The antidiabetic analysis revealed Armoracia Rusticana was highly active against α-glucosidase with IC50 values of 5.6 µg/ml. Furthermore, molecular docking was used to identify the active constituents against α-glucosidase, while using acarbose as a controlled drug. Results: Upon phytochemical screening, it was found that six out of ten phytochemicals were successfully docked in the respective binding sites. The lead phytochemical was Quercetin 3-O-beta-D-xylopyranoside which displayed a more binding score as compared to acarbose. They were subjected to analyze for drug-like properties which further strengthen its validation. Conclusion: It was, therefore, concluded that Armoracia Rusticana might potentially be used in the amelioration of type 2 diabetes. Potential molecules identified from this study could be considered as a lead drug to cure diabetes mellitus.

Root Vegetables—Composition, Health Effects, and Contaminants

“…Isothiocyanates formed from the breakdown of GLS are responsible for most of the properties of Armoracia rusticana , including its taste and smell. Allyl isothiocyanate is the main compound causing the pungent taste and lacrimation [ 71 ]. These are volatile substances; therefore, the storage of horseradish, even in a cool room (5 °C), causes a reduction in their levels, even up to 50% [ 71 , 72 ].…”

“…Allyl isothiocyanate is the main compound causing the pungent taste and lacrimation [ 71 ]. These are volatile substances; therefore, the storage of horseradish, even in a cool room (5 °C), causes a reduction in their levels, even up to 50% [ 71 , 72 ].…”

Synthesis and α-Glucosidase Inhibition Activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl]-N-arylacetamides: An In Silico and Biochemical Approach

“…Similarly, various 1,2-benzothiazine 1,1-dioxides have been reported as antileukemic [25][26][27], 11β-HSD1 inhibitors [28], endotheline receptor antagonists [29], antimalarial agents [30], MAO inhibitors [31], antiallergic agents [32], antithrombotics [33], antiparasitic [34], antimicrobials [35,36], antioxidants [37], inhibitors of calpain I [38], and aldose reductase enzymes [39,40]. Our research group is involved in the search for novel and more effective antidiabetic agents [41][42][43][44][45], and in this context we have synthesized novel 1,2-benzothiazine-N-arylacetamides and screened them for their in silico and in vitro α-glucosidase inhibitory potential.…”

“…Our research group is involved in the search for novel and more effective antidiabetic agents [41][42][43][44][45], and in this context we have synthesized novel 1,2-benzothiazine-Narylacetamides and screened them for their in silico and in vitro α-glucosidase inhibitory potential.…”

Integrating Pharmacological and Computational Approaches for the Phytochemical Analysis of Syzygium cumini and Its Anti-Diabetic Potential

“…Deoxy-nojirimycin (DNJ) is also a plant derived anti-diabetic compound isolated from Morus alba L. extract [ 26 ]. Recent studies have identified many phytochemicals from S.cumini with potential inhibitory activity against α-glucosidases and amylases [ 27 ].…”