Phytochemical Analysis and Antifungal bioactivity of  Pulicaria undulata  (L.) Methanolic Extract and Essential Oil

Helal, Nesma M.; Ibrahim, Nevin; Khattab, Hemmat

doi:10.21608/ejbo.2019.12259.1308

Cited by 9 publications

(7 citation statements)

References 49 publications

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“…It should be mentioned that some compounds identified in M. vulgare have been identified in other plants such as cyclotetrasiloxane and octamethyl, identified in the methanol extract of Dillenia scabrella Roxb. (Dilleniaceae) and the methanolic extract of Pulicaria undulata L. (Asteraceae) [ 42 , 43 ]. Silanol, trimethyl-, phosphate was identified in Anacardium occidentale nut [ 44 ] also in the extract of Terminalia bellirica (Combretaceae) seed [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.

Mssillou

Agour

Hamamouch

et al. 2021

The Scientific World Journal

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In this study, the polyphenol content and the antioxidant and antimicrobial activities of hydroethanolic (MVE) and hydroacetonic (MVA) leaf extracts of Marrubium vulgare L. were examined. The results indicated that the total phenolic content was higher in MVA (112.09 ± 4.77 mg GAE/DW) compared to MVE extract (98.77 ± 1.68 mg GAE/DW). The total flavonoid content was also higher in MVA extract (21.08 ± 0.38 mg QE/g DW) compared to MVE (17.65 ± 0.73 mg QE/g DW). Analysis of the chemical composition revealed the presence of 13 compounds with a total of 96.14%, with the major compound being malic acid (22.57%). Both extracts possess a good total antioxidant activity. DPPH and FRAP assays indicated that the MVE extract possesses a better antioxidant activity, with IC50 = 52.04 µg/mL ± 0.2 and EC50 of 4.51 ± 0.5 mg/mL, compared to MVA extract (IC50 = 60.57 ± 0.6 µg/mL and EC50 of 6.43 ± 0.0411 mg/mL). Moreover, both extracts exhibited strong antimicrobial activity against certain nosocomial strains as indicted by the MIC values, which ranged between 0.93 mg/mL and 10 mg/mL. Taken together, these results reveal the importance of M. vulgare as a natural antioxidant with important antimicrobial activity.

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Section: Resultsmentioning

confidence: 99%

Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.

Mssillou

Agour

Hamamouch

et al. 2021

The Scientific World Journal

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“…The higher concentrations of these constituents, together with the high levels of the antioxidant activity, and the currently investigated antimicrobial activity of P. undulata , together with the presence of several fatty acid constituents (including linoleic acid), has made this Saudi Arabian species, P. undulata , a good source of nutrition and a prominent ethnomedicinal herb of the region that is frequently used as part of traditional medicine. A comparative assessment of these characteristics of the locally distributed P. undulata in comparison to other locations dispersed species also substantiated the nutritional claims, and food, feed, and ethnomedicinal practices [ 65 , 66 ].…”

Section: Resultsmentioning

confidence: 94%

Chemical Profile, Antioxidant, Antimicrobial, and Anticancer Activities of the Water-Ethanol Extract of Pulicaria undulata Growing in the Oasis of Central Saudi Arabian Desert

Mohammed

Al-Omar

Khan

et al. 2021

Plants

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Pulicaria undulata (L.) C. A. Mey has multiple uses as part of traditional medicament, and several biological activities of the plant have been corroborated in the scientific literature. The current work evaluates the phytochemical constituents and biological properties of the water-ethanol extract of the P. undulata growing in Qassim, the central arid regions of Saudi Arabia. Qualitative UPLC-ESIQ-TOF analysis identified 27 compounds belonging to the phenolics, flavonoids, triterpenes, coumarins, and fatty acids chemical class. The quantitative analysis exhibited 33.3 mg/g GAE (Gallic Acid Equivalents), and 10.8 mg/g QE (Quercetin Equivalent) of the phenolics and flavonoids in the plant’s concentrated (to dryness) water-ethanol extract. The trace elements analysis of the plant’s dry powder established the presence of copper (20.13 µg/kg), and zinc (68.2 µg/kg) in the higher levels of occurrences. In terms of the antioxidant potential of the plant’s extract, the ferric-reducing, and free-radicals scavenging activities were recorded at 47.11 mg/g, and 19.13 mg/g equivalents of the concentrated to dryness water-ethanol extract of the plant. The water-ethanol extract of P. undulata also exhibited antimicrobial activity against the tested Gram-positive bacteria, while no activity was observed against the tested Gram-negative bacteria, or the fungi. The MIC (minimum inhibitory concentration) values were in the range of 49 to 1563 µg/mL, whereas the MBC (minimum bactericidal concentration) values ranged from 49 to 3125 µg/mL, against the tested Gram-positive bacteria. The P. undulata water-ethanol extract also exhibited potent cytotoxic effects with the IC50 value at 519.2 µg/mL against the MCF-7 breast cancer cell-lines, followed by the anticancer activity of erythroleukemic cell-lines, K562 at 1212 µg/mL, and pancreatic cell-lines, PANC-1, at 1535 µg/mL, as compared to the normal fibroblast cells (4048 µg/mL). The Annexin-V assay demonstrated that, as the P. undulata extract’s dose increased from IC50 to twice of the IC50, the percentage of necrosis was found to be increased in the late apoptosis of the cancer cells. These data confirmed the P. undulata extract’s ability to inhibit several human cancer cell lines’ growth in comparison to other local halophytes. The antimicrobial activity of the plant was also confirmed.

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“…26 2-ethyl-1-hexanol, is a potent volatile compound have an antifungal activity such as Fusarium, 27 Cyclotrisiloxane, hexamethyl-presented good antioxidant and antifungal activities against the mycoses, which are caused a high mortality rate of individuals with compromised immune systems. 28 According to Gaafar et al, the Cyclopentasiloxane, decamethyl-is detected in other plant extracts using GC/MS analysis, it may be contributing in the cytotoxicity effect against colon cancer cells (HCT116) and breast cancer cells (MCF-7). It may be exhibit an antiviral activity against avian influenza H5N1 virus through the inhibition of their viral adsorption, replication and propagation process.…”

Section: Resultsmentioning

confidence: 99%

Gas Chromatography Analysis, Mineral Contents and Anti-inflammatory Activity of Sonchus maritimus

2024

TJNPR

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The previously mentioned phytocompounds have been shown in previous research to have a wide range of pharmacological activities, such as antibacterial action, antitumor effect, hepatoprotective, neuroprotective, cardiovascular therapy, rheumatism and general pain, in addition to their anti-aging and general tonic properties. 6 Furthermore, the phytochemicals activate the immune system, reduce oxidation, reduce inflammation, block the formation of carcinogens and slow the growth of cancer cells. 7 Because of therapeutic properties of volatile compounds which have been employed in numerous conventional medical systems. Volatile compounds have been considered to be an effective alternative to synthetic and chemical medications, which often have unfavorable side effects. Therefore, numerous plant sources have been investigated in recent research for the synthesis of volatile chemicals. 8 This investigation focused on phytochemical screening of the leaves aqueous extract of Sonchus maritimus and identification of volatile components using GC analysis with evaluation of its anti-inflammatory activity. MethodologyCollection and Identification of plant material Sonchus maritimus was obtained in November 2021 from Djamaa region at coordinates 33° 32′ 0″ N, 6° 0′ 0″ E, situated at an altitude of 41 m (135 ft) in El-Oued state, Algeria; and its taxonomy was confirmed by a botanist (Pr. Halis Youcef) in CRSTRA Touggourt. Voucher specimen number: FSNV/DB/consult/2021/88-14-05 was deposited.

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Phytochemical Analysis and Antifungal bioactivity of Pulicaria undulata (L.) Methanolic Extract and Essential Oil

Cited by 9 publications

References 49 publications

Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.

Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.

Chemical Profile, Antioxidant, Antimicrobial, and Anticancer Activities of the Water-Ethanol Extract of Pulicaria undulata Growing in the Oasis of Central Saudi Arabian Desert

Gas Chromatography Analysis, Mineral Contents and Anti-inflammatory Activity of Sonchus maritimus

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