Phytochemical Analysis and Biological Activities of<i>Cola nitida</i>Bark

Dah-Nouvlessounon, Durand; Adoukonou‐Sagbadja, Hubert; Nafan, Diarrassouba; Sina, Haziz; Adjanohoun, Adolphe; Inoussa, Mariam; Akakpo, Donald; Gbénou, Joachim; Kotchoni, Simeon O.; Dicko, Mamoudou H.; Baba-Moussa, Lamine

doi:10.1155/2015/493879

Cited by 42 publications

(24 citation statements)

References 36 publications

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“…The variability of the yields obtained at the end of the extraction could be explained by the extraction capacity of each solvent. Indeed, the affinity of this solvent with respect to the phytomolecules and its polarity influences the yield (12). With the exception of the extracts of U.chamae, the yield of the ethanol extract of all the plants studied is higher than that of the aqueous extract.…”

Section: Discussionmentioning

confidence: 95%

Exploration of the antibacterial and chemical potential of some Beninese pharmacopoiea traditional plants

et al. 2018

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SummaryObjectives. This study aims to evaluate the antibacterial and chemical properties of some medicinal plants used in the fight against enteropathogens in Benin.Methods. Aqueous and ethanolic extracts of Senna siamea, Uvaria chamae, Lantana camara and Phyllantus amarus were tested on 10 bacterial strains. Well diffusion technique, coupled with the microdilution determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (CMB) was used for antibacterial testing. The larval cytotoxicity was evaluated by using Artemia salina crustacean larvae. flavonoids and polyphenols were also assayed by the method using aluminum trichloride (AlCl3) and the method using the folin-Ciocalteu reagent, respectively.Results. The results of the study revealed that extracts had an effective antibacterial activity at 100 mg/mL, with MIC between 100 and 25 mg/mL and CMB between 100 and 50 mg/mL. The inhibition diameters of the extracts varied between 7.5 and 21 mm. The ethanolic extract of Phyllantus amarus leaves showed the best antibacterial activity. None of the extracts tested was found to be cytotoxic at the dose of 20 mg/mL. The aqueous Uvaria chamae root extract has the highest polyphenol content (231.896552±0.27586207 in μg EAG/100 mg extract), whereas the aqueous leaf extract of Uvaria chamae is the richest in flavonoids (41.061082 0.43180737 in μg ER/100 mg of extract).Conclusions. These interesting results can be used in the development of improved traditional medicines against enteropathogens. IntroductionInfections caused by enteropathogens are serious forms of infectious pathology. They are a major public health problem that causes millions of deaths a year. This is the case, for example, of foodborne illnesses, causing 17 million deaths a year worldwide, more than half of which come from the African continent (37). Diarrheal diseases are also the cause of 550 million patients each year, including 220 million children under 5 years of age (37). Salmonella, shigella and klebsielles are amongst others epidemiologically active enterobacteria involved in serious infectious diseases.Health management of enteropathogenic diseases is achieved through the use of antibiotics, but their inadequate and often anarchic use has resulted in bacterial resistance (24,36). Indeed, recent data from the bibliography abound with descriptions of bacteria that are multiresistant or even toto-resistant to antibiotics. The number of these bacteria is increasing in both industrialized and developing countries (32). This development of microbial resistance to antibiotics has led researchers to carry out alternative investigations to identify other effective natural remedies against various pathologies in the plant kingdom (18). It has therefore proved essential to look for new antibacterial substances that are effective and have a broad spectrum of action. One of the effective strategies for this research is to explore plants used in traditional Correspondence: Victorien T. Dougnon, Lecturer-Researcher in Microb...

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Section: Discussionmentioning

confidence: 95%

Exploration of the antibacterial and chemical potential of some Beninese pharmacopoiea traditional plants

et al. 2018

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“…The extraction method described by [7] was used. A mass of 50 g of powder of the leaf and steam was macerated in 500 ml of solvent: methanol and water ethanol mixture in the proportions 30:70 (v/v) under stirring for 48 hours.…”

Section: Obtaining Extractsmentioning

confidence: 99%

Phytochemical Screening and Antimicrobial Activity of <i>Desmodium ramosissimum</i>

Toyigbénan¹,

Dah-Nouvlessounon²,

Sina³

et al. 2020

AJPS

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Microbial infections threaten the health of the Beninese population. Objectives: To identify bioactive phytochemical groups and evaluate the antimicrobial activity of Desmodium ramosissimum used in traditional medicine in Benin against microbial infections. Methodology & Results: The classic reactions in solution helped highlight alkaloids, anthocyanins, flavonoids, quinones, saponins, steroids, tannins, terpenoids, mucilage, Coumarin, reducing compounds, anthracene, glycosides. The antibacterial activity was evaluated by extracts dilution's method (ethanol extracts, methanol extracts and hexane extracts). The methanol extract inhibited the growth of all tested germs, with a significant effect on E. coli and S. aureus strains whose MIC values are equal to 1.25 mg/ml. On the contrary, this extract has a low activity on P. vulgaris strain with a MIC of 10 mg/ml. The ethanol extract also inhibited the growth of all the tested strains, but with more intense activity than the methanol extract. The strains of C. albicans and S. oralis were more sensitive to the extract with 0.625 mg/ml for MIC, while S. aureus and P. vulgaris were less sensitive (MIC = 5 mg/ml). The residual ethanol extract exerted inhibition on all microorganisms at a concentration of 20 mg/ml, except the strain of E. foecalis that was resistant. Conclusion & Applications: This study shows that besides its food virtues of this plant, there are antibacterial and antifungal properties.

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“…The methanolic extract produced the highest yield, whereas the lowest was obtained with the ethyl acetate ones. It could be because of the extraction capacity of a solvent depends on its polarity and affinity for phyto-molecules (Dah-Nouvlessounon et al, 2015). Furthermore, the majority of natural's products seem more soluble in methanol than other more polar solvents (Telli et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Comparative in vitro antimicrobial effect of Sarcocephalus latifolius (Sm.) E. A. Bruce leaves and roots on foodborne pathogens

Ahoyo¹,

Deguenon²,

Dah-Nouvlessounon³

et al. 2019

Afr. J. Microbiol. Res.

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Sarcocephalus latifolius (Sm.) E. A. Bruce is a plant used traditionally to treat a wide range of infectious diseases, including foodborne ones. This study aimed to compare its roots and leaves extract antibacterial effects in vitro. Thus, these organs were collected, dried and powdered for the extractions and phytochemical screening. Four extracts (water, ethyl-acetate, methanol and ethanol) were tested on ten references strains (RS) and nine non references strains of Staphylococcus isolated from meat strains (MS) using disk method. Minimal inhibitory (MIC) and bactericidal concentrations (MBC) were determined respectively by macrodilution method and by solid culture medium. The results showed that the MS seem more susceptible than RS. The lowest activity was shown by roots hydro-ethanolic extract on Micrococcus luteus, whereas the highest was obtained with leaves ethanolic extract on Staphylococcus cohini. The MIC ranges from 0.312 to 25 mg/ml for the MS and from 6.25 to 12.50 mg/ml for the RS. About MBC, they vary from 12.50 to 50 mg/ml for all susceptible tested microorganisms. S. latifolius extracts have an inhibitory effect on both strains such as Staphylococcus xylosus, Escherichia coli O157, Staphylococcus sciuri, Staphylococcus aureus, M. luteus, Candida albicans, S. cohinii, Proteus mirabilis and bactericidal effect on the three last ones. These results support the traditional use of S. latifolius in infectious diseases control; furthermore, its leaves seem more effective than the roots. These findings may serve as a starting point for the development of a new drug for the control of this kind of diseases and could sustain the species use.

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Phytochemical Analysis and Biological Activities ofCola nitidaBark

Cited by 42 publications

References 36 publications

Exploration of the antibacterial and chemical potential of some Beninese pharmacopoiea traditional plants

Exploration of the antibacterial and chemical potential of some Beninese pharmacopoiea traditional plants

Phytochemical Screening and Antimicrobial Activity of <i>Desmodium ramosissimum</i>

Comparative in vitro antimicrobial effect of Sarcocephalus latifolius (Sm.) E. A. Bruce leaves and roots on foodborne pathogens

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Phytochemical Analysis and Biological Activities ofCola nitidaBark

Cited by 42 publications

References 36 publications

Exploration of the antibacterial and chemical potential of some Beninese pharmacopoiea traditional plants

Exploration of the antibacterial and chemical potential of some Beninese pharmacopoiea traditional plants

Phytochemical Screening and Antimicrobial Activity of &lt;i&gt;Desmodium ramosissimum&lt;/i&gt;

Comparative in vitro antimicrobial effect of Sarcocephalus latifolius (Sm.) E. A. Bruce leaves and roots on foodborne pathogens

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Phytochemical Screening and Antimicrobial Activity of <i>Desmodium ramosissimum</i>