Objective: The present study was carried out with an objective to evaluate the protective effect of methanolic extract of Aloe vera Bryophyllum pinnatum leaf gel and leaf against smokeless tobacco Gutkha (STG) induced toxicity in the kidney of Albino mice.: The Swiss albino mice were divided into six (6) groups, among which Materials and Methods two groups were treated with 100mg/kg and 200mg/kg body weight doses of STG orally for 90 days. Another three groups of mice were given STG along with and leaf extracts singly (300 mg/kg) b. wt and in A. vera B. pinnatum combination (mixture of both plant in 1:1 proportion) at an interval of 10 hours. Changes in kidney were evaluated at histological (LM and SEM level) and biochemical (SOD, CAT and MDA) level by following standard procedures. Results: LM analysis of histological structure of kidney revealed swelling and individualization of tubular epithelial cells, glomerular proliferation along with atrophied and enlarged glomerulus in STG treated mice. SEM analysis of surface structure of kidney of STG treated animals showed heterogenous surface morphology with reduced, necrosed and individualized tubules of kidney. Significant (p<0.01) alterations were also observed in selected enzyme parameters of STG treated mice. However, such histological and biochemical changes were not observed in and A. vera B. pinnatum A. extract treated animals.: Result of the present study suggested the ameliorative potential of Conclusion vera B. pinnatum and methanolic extract against STG induced nephrotoxicity with more efficacy of combined mixture than their individual application.