Phytochemical analysis and Enzyme Inhibition Assay of Aerva javanica for Ulcer

Khan, Abdul Wajid; Jan, Saleem; Parveen, Shaista; Khan, Rahmat Ali; Saeed, Asma; Tanveer, Abdul Jabbar; Shad, Anwar Ali

doi:10.1186/1752-153x-6-76

Cited by 36 publications

(20 citation statements)

References 10 publications

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“…Urease (urea amidohydrolase) is usually found in different bacteria, fungi, algae, and plants, an enzyme that catalyzes the hydrolysis of urea to ammonia and carbamate, which is the final step of nitrogen metabolism in living organisms [1]. Carbamate rapidly and spontaneously decomposes, yielding a second molecule of ammonia.…”

Section: Introductionmentioning

confidence: 99%

Urease Inhibitory Activity of Aerial Parts of Artemisia scoparia: Exploration in an In Vitro Study

Khan

Tariq

et al. 2014

Ulcers

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Artimisia scoparia has been used in the treatment of different disorders including ulcers. The current study was therefore designed to investigate the aerial parts of Artemisia scoparia (crude extract, total sterol and flavonoidal contents, and aqueous fraction) for its urease inhibitory potential. The crude of the plant evoked marked attenuation on urease activity, when tested in various concentrations with IC50 values of 4.06 mg/ml. The inhibitory potential was further augmented in the aqueous fraction (IC50: 2.30 mg/ml) of the plant. When the total sterol and flavonoidal contents were challenged against urease, both showed concentration dependent activity; the latter showed maximum potency with IC50 values of 8.04 and 2.10 mg/ml, respectively. In short, the aerial parts of the plant demonstrated marked antagonism on urease and thus our study validated the traditional use of Artemisia scoparia in the treatment of ulcer.

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Section: Introductionmentioning

confidence: 99%

Urease Inhibitory Activity of Aerial Parts of Artemisia scoparia: Exploration in an In Vitro Study

Khan

Tariq

et al. 2014

Ulcers

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“…Antiulcer (Khan et al, 2012). Hepatoprotective and nephroprotective (Arbab et al, 2016;Movaliya & Zaveri, 2014).…”

Section: Aerva Javanicamentioning

confidence: 99%

Ethnobotanical, Phytochemical, and Biological Study of Tamarix aphylla and Aerva javanica Medicinal Plants Growing in the Asir Region, Saudi Arabia

Suleiman

2019

Tropical Conservation Science

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In this study, Tamarix aphylla and Aerva javanica, plants used in folkloric medicine in the Asir region of Saudi Arabia were studied ethnobotanically, chemically, and biologically to assess their medicinal uses, phytochemical constituents, and biological activities. Ethnobotanical data were collected using semistructured interviews and the use values were calculated. A total of 61 informants were interviewed and results indicated high-value uses (0.9 and 0.7) for the plants. Phytochemical investigation indicated that the plants contained most of the phytochemicals that were tested for. The antioxidant activity was examined by assaying total phenolic content, 1,1-Diphenyl-2-picrylhydrazyl (DPPH), and hydrogen peroxide (H 2 O 2) radical scavenging activity. .The bark extract of T. aphylla showed the best antioxidant effect in total phenolic content, DPPH, and H 2 O 2 assays (278.02 AE 0.16 mg GAE/100 g; The half-maximal inhibitory concentration (IC 50): DPPH, 18.39 AE 0.62 lg/mL; H 2 O 2 , 252.94 AE 1.86 lg/mL), followed by extract of the A. javanica aerial parts (228.60 AE 2.09 mg GAE/100 g; IC 50 : DPPH, 28.54 AE 0.53 lg/mL; H 2 O 2 , 154.17 AE 0.78 lg/mL) compared with ascorbic acid (DPPH: 27.27 AE 0.11 lg/mL; H 2 O 2 : 164.9 AE 0.37 lg/mL). The disc diffusion method performed for antimicrobial activity revealed weak activities in T. aphylla and A. javanica extracts (100 lg/mL) against six human pathogens. It was concluded that these plants possess therapeutic potential in the treatment of 18 types of ailments, which are important phytochemical constituents and antioxidant activities that justify their therapeutic uses in traditional medicine. Thus, this study laid sufficient background for further pharmacological research on extracts of these plants.

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“…Anti-ulcer activity: The breaking in the gastric lining is known as ulcer; it is named differently depending on the part of gastric system damaged [51]. A. javanica's ethyl acetate fraction of methanolic extract has been reported to display medium level antiulcer activity at a concentration of 0.2 mg/mL [52]. The extract of the roots of A. persica in ethanol was examined for antiulcer activity in albino Wistar mice.…”

Section: Review On Aerva Plantsmentioning

confidence: 99%

“…[52], while, A. persica was found to contain 3, 4ʹ dihydroxy-3ʹ, 5ʹ-dimethoxy propiophenone (82), 4-ethoxy benzoic acid (83), 4hydroxybenzaldehyde (84), 4-hydroxybenzoic acid (85) and 3hydroxybenzoic acid(86) [102] (Figure 10).…”

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confidence: 99%

Pharmaceutical, Ethnopharmacological, Phytochemical and Synthetic Importance of Genus Aerva: A Review

Musaddiq

Mustafa

Ahmad

et al. 2018

Natural Product Communications

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Aerva plants are known widely for their exceptional medicinal uses. They have been employed conventionally for their medicinal properties by the common folk in several regions of the world. This indicates the efficacy of these remarkable herbs. They are also known for their multiple biological activities such as antioxidant, antibacterial, antilithiatic, hepatoprotective, antidiabetic, anticancer, antihyperlipidemic and nephroprotective potential. These pharmacological actions are associated with the presence of valuable nutrients and biochemical compounds such as sterols/terpenes, flavonoids, alkaloids, phenolics and sugars. The proper utilization of the substances obtained from these plants can enhance the finesse of the capabilities of these plants. These plants are not only medicinally important but are significantly serving several other scientific purposes. In the prospect of medicinal, scientific uses and the bioavailability of precious chemicals of Aerva species, a comprehensive review is compiled, which focuses on the detailed profile of biochemical compounds, pharmacological functions and biological activities of Aerva plants. The review also discusses the synthetic importance and the toxicity of these plants. The study aims to compile comprehensively what is already done and what more is needed to be done in the future investigations related to Aerva species.

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Phytochemical analysis and Enzyme Inhibition Assay of Aerva javanica for Ulcer

Cited by 36 publications

References 10 publications

Urease Inhibitory Activity of Aerial Parts of Artemisia scoparia: Exploration in an In Vitro Study

Urease Inhibitory Activity of Aerial Parts of Artemisia scoparia: Exploration in an In Vitro Study

Ethnobotanical, Phytochemical, and Biological Study of Tamarix aphylla and Aerva javanica Medicinal Plants Growing in the Asir Region, Saudi Arabia

Pharmaceutical, Ethnopharmacological, Phytochemical and Synthetic Importance of Genus Aerva: A Review

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