Phytochemical Analysis and Evaluation of In Vitro Anti Oxidant Activity of Punica Granatum Leaves

Boggula, Narender; Peddapalli, Himabindu

doi:10.25258/phyto.v9i08.9618

Cited by 12 publications

(13 citation statements)

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“…While P. granatum leaf powder contained Saponins, it was not found in O. europaea. These results are in agreement with previous findings of (Lahmadi et al, 2019), (Shah et al, 2017) and (Boggula and Peddapalli, 2017).…”

Section: Resultssupporting

confidence: 94%

Evaluation of the Insecticidal Activity of Punica granatum L. and Olea europaea L. against the Dry Bean Beetle , Acanthoscelides obtectus (Say) (Coleoptera:Bruchidae)

Mohamed

2020

Journal of Plant Protection and Pathology

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A laboratory study was carried to determine the efficacy of Punica granatum Linn. and Olea europaea L. leaf powders a gainst adults of the dry bean beetle, Acanthoscelides obtectus (Say) (Coleoptera:Bruchidae) under laboratory conditions . The death rate of A. obtectus increased gradually with increasing the concentration and period of exposure to powdered plant leaves. After 120 hours of exposure to the powdered plant leaves, P. granatum caused adult mortality 82.17%, while O. europaea caused adult death 68.14%. In case of P. granatum leaf powders, the LC50 value was 16.73 g / 30 g white kidney bean while LT50 recorded 69.01 hours at 25 g / 30 g white kidney bean. While the maximum effectiveness of inhibition oviposition was recorded by using P. granatum leaf powder (75.06 %) compared to O. europaea (53.11 %). A decrease in adult exit was reported among the treatments and the maximum decrease was noticed in the dry white beans with the highest dose rate leaves powder of P. granatum (68.19%) and O. europaea (52.38%). Results obtained from this study revealed that the used plant leaf powders significantly reduced the infestation and the weight loss for white kidney bean. However, P. granatum had higher activity against A. obtectus than O. europaea. There is no doubt that both plants under study have a significant effect on the pest, and accordingly, they can be used in the production of environmentally friendly plant-based insecticides.

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Section: Resultssupporting

confidence: 94%

Evaluation of the Insecticidal Activity of Punica granatum L. and Olea europaea L. against the Dry Bean Beetle , Acanthoscelides obtectus (Say) (Coleoptera:Bruchidae)

Mohamed

2020

Journal of Plant Protection and Pathology

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“…They include P. granatum, P. guajava, C. arborea, G. decora, S. obtusa, and F. hispida. The findings about the potential effectiveness of these plants are similar to those found in the in vivo and in vitro studies previously reported [31][32][33][34][35][36][37][38][39][40]. Leaves from P. granatum and P. guajava and pieces of bark from C. arborea, G. decora, S. obtusa, and F. hispida were collected in Baan Tham, Dok Kham Tai, Phayao.…”

Section: Collection and Preparation Of The Extractssupporting

confidence: 82%

Anti-Inflammatory and Antioxidant Activities of Medicinal Plants Used by Traditional Healers for Antiulcer Treatment

et al. 2019

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For centuries, many kinds of native plants and their products have been used for the treatment of gastric ulcers by traditional healers in Phayao province. The current study aimed to investigate the polyphenol content in some of these medicinal plants and to point out the relationship between their antioxidant capacity and anti-inflammatory activities. Six species were selected based on ethnopharmacologic considerations: Punica granatum L., Psidium guajava L., Careya arborea Roxb., Gochnatia decora (Kurz) Cabr., Shorea obtusa Wall. ex Blume, and Ficus hispida L.f. The leaves or bark of these plants were extracted with 70% ethanol and water. Anti-inflammatory and antioxidant activities of the extracts were analyzed based on nitric oxide (NO) and proinflammatory cytokine production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and through the determination of scavenging activity. The results demonstrated that the ethanol extract from P. granatum and P. guajava leaves significantly inhibited NO production by suppressing nitric oxide synthase. The extracts also inhibited tumor necrosis factor-α, interleukin-1, and interleukin-6 in terms of both mRNA and protein levels and possessed high antioxidants. These extracts were shown to contain the highest amount of polyphenols. Our study concluded that among the plants studied, P. granatum and P. guajava have the most significant anti-inflammatory and antioxidant activities and polyphenols. These plants may have the potential for use in gastric ulcer therapy due to their indicated properties. Future research should focus on the isolation of their active compounds and their in vivo biological activities. Their beneficial applications need to be warranted by such evidence.

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“…Most antiviral studies have been performed on the fruitʼs peel and juice, and it has been found that extracts exerted inhibitory activity against HSV-2, HIV-1, and the influenza virus [8][9][10]. Little information has been reported on pomegranate leaf extracts, compared to other edible and nonedible parts of the plant, although some recent studies have indicated that they may be an important source of specialized bioactive metabolites and they possess a broad range of biological properties, such as in vitro antioxidant, anti-inflammatory, anticholinesterase, and antiproliferative activities [5,11,12]. This study explores the cytotoxicity and anti-ZIKV activity of pomegranate leaf ethanolic extracts, as well as of the corresponding fractions and phytoconstituents after a phytochemical and biomolecular characterization of the leaves, which were collected from various sites, after different vegetative periods, and in different years.…”

Section: Introductionmentioning

confidence: 99%

Punica granatum Leaf Ethanolic Extract and Ellagic Acid as Inhibitors of Zika Virus Infection

et al. 2020

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Zika virus, an arthropod-borne flavivirus, is an emerging healthcare threat worldwide. Zika virus is responsible for severe neurological effects, such as paralytic Guillain-Barrè syndrome, in adults, and also congenital malformations, especially microcephaly. No specific antiviral drugs and vaccines are currently available, and treatments are palliative, but medicinal plants show great potential as natural sources of anti-Zika phytochemicals. This study deals with the investigation of the composition, cytotoxicity, and anti-Zika activity of Punica granatum leaf ethanolic extract, fractions, and phytoconstituents. P. granatum leaves were collected from different areas in Italy and Greece in different seasons. Crude extracts were analyzed and fractionated, and the pure compounds were isolated. The phytochemical and biomolecular fingerprint of the pomegranate leaves was determined. The antiviral activities of the leaf extract, fractions, and compounds were investigated against the MR766 and HPF2013 Zika virus strains in vitro. Both the extract and its fractions were found to be active against Zika virus infection. Of the compounds isolated, ellagic acid showed particular anti-Zika activities, with EC50 values of 30.86 µM for MR766 and 46.23 µM for HPF2013. The mechanism of action was investigated using specific antiviral assays, and it was demonstrated that ellagic acid was primarily active as it prevented Zika virus infection and was able to significantly reduce Zika virus progeny production. Our data demonstrate the anti-Zika activity of pomegranate leaf extract and ellagic acid for the first time. These findings identify ellagic acid as a possible anti-Zika candidate compound that can be used for preventive and therapeutic interventions.

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Phytochemical Analysis and Evaluation of In Vitro Anti Oxidant Activity of Punica Granatum Leaves

Cited by 12 publications

References 0 publications

Evaluation of the Insecticidal Activity of Punica granatum L. and Olea europaea L. against the Dry Bean Beetle , Acanthoscelides obtectus (Say) (Coleoptera:Bruchidae)

Evaluation of the Insecticidal Activity of Punica granatum L. and Olea europaea L. against the Dry Bean Beetle , Acanthoscelides obtectus (Say) (Coleoptera:Bruchidae)

Anti-Inflammatory and Antioxidant Activities of Medicinal Plants Used by Traditional Healers for Antiulcer Treatment

Punica granatum Leaf Ethanolic Extract and Ellagic Acid as Inhibitors of Zika Virus Infection

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