Phytochemical Analysis and Some Bioactivities of Leaves and Fruits of Myrsine africana Linn

Laraib, Sadaf; Sharif, Saiqa; Bibi, Yamin; Nisa, Sobia; Aziz, Rukhsanda; Qayyum, Abdul

doi:10.1007/s13369-020-04710-4

Cited by 10 publications

(5 citation statements)

References 24 publications

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“…In this study also, the methanolic extract of M. africana has shown better antioxidant activity ( Figure 1 ). Therefore, the presence of such phytonutrients in M. africana might contribute to the lowering of blood glucose levels [ 7 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

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Methanolic Extract of Myrsine africana Leaf Ameliorates Hyperglycemia and Dyslipidemia in Alloxan-Induced Diabetic Albino Mice

Amare

2021

Evidence-Based Complementary and Alternative Medicine

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Background. Diabetes mellitus is one of the leading public health problems globally, and its prevalence is increasing in Ethiopia. The current drugs for people with diabetes are costly, less effective, and less safe with a challenging administration method. Thus, globally, the need for alternative herbal antidiabetic medicines is increasing. In the previous studies, antioxidant activities have been seen in crude extracts of M. africana leaves, which is an auspicious sign of antidiabetic property. Accordingly, this study has evaluated the antidiabetic and antidyslipidemic activities of methanolic extract of M. africana leaves. Methods. Hypoglycemic and antihyperglycemic activities of the three doses (250 mg/kg, 500 mg/kg, and 1000 mg/kg) of crude methanolic extract of M. africana leaf were studied on normoglycemic, oral glucose-loaded, and alloxan-induced diabetic mice models. The effect of the extract on diabetic dyslipidemia, insulin and glycated hemoglobin levels, carbohydrate-metabolizing enzymes, and body weight was also studied in alloxan-induced diabetic mice. Glibenclamide (5 mg/kg) was used as a standard drug in all cases. Data analysis was carried out using mixed-design ANOVA. A P value of ≤0.05 was considered a statistically significant difference. Results. The methanolic extract of M. africana leaf did not show acute toxicity up to the dose of 5000 mg/kg and showed better glucose utilization in the oral glucose tolerance test. After 14 days of treatment, M. africana leaf extract decreased the blood glucose level, glycated hemoglobin, glucose-6-phosphatase, and fructose-1-6-bisphosphatase in diabetic mice. In contrast, it increased hexokinase and insulin levels in diabetic mice. Moreover, weight loss and dyslipidemia profiles have been corrected significantly in diabetic mice. Conclusion. M. africana leaves showed antihyperglycemic and antidyslipidemic effects in alloxan-induced diabetic mice. That suggests M. africana may be a potential treatment option for diabetes in the future. However, further molecular studies are required to analyze the mechanisms.

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Section: Discussionmentioning

confidence: 99%

“…Myrsine africana ( M. africana ), also called Cape Myrtle or African boxwood, belongs to the family Myrsinaceae and is an evergreen shrub growing to 2 m at a slow rate. The plant is native to Africa and Asia and usually grows well in dry parts [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Methanolic Extract of Myrsine africana Leaf Ameliorates Hyperglycemia and Dyslipidemia in Alloxan-Induced Diabetic Albino Mice

Amare

2021

Evidence-Based Complementary and Alternative Medicine

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“…were screened for the presence of phytochemical compound according to the procedure described by Harbone. 13 Phytochemical reagent added to the extract and fraction solution. The qualitative results are expressed as (+) for the presence of a phytochemical compounds and (-) for the absence of a phytochemical compounds.…”

Section: Phytochemicals Screeningmentioning

confidence: 99%

Antimicrobial properties of various solvents combinations for phytochemical fraction derived from Uncaria gambier extract against Enterococcus faecalis ATCC 29212

2021

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Introduction: Enterococcus faecalis is often found in root canal infections and can cause failure in root canal treatment. Uncaria gambier is an herbal medicine that is known to be rich in polyphenol compounds that have antibacterial properties. Because of the polyphenol content and antibacterial properties of Uncaria gambier, it can be an alternative as an antibacterial solution for root canal treatment. The purpose of this study is to analyze the antimicrobial of various solvents combinations for phytochemical fraction derived from Uncaria gambier extract against Enterococcus faecalis (ATCC 29212). Methods: This study is descriptive explorative research Uncaria gambier was extracted using a combination of three different fractions, ethyl acetate-water, hexane-water and hexane-ethyl acetate. We determine the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) against Enterococcus faecalis (ATCC 29212) using the serial microdilution method and by add test samples to the Mueller Hinton agar medium from each fraction Results: Combination ethyl acetate-water has MIC value at 0.195 mg/ml, combination hexane-water at 0.049 mg/ml and combination hexane-ethyl acetate have the MIC value at 1.563 mg/ml. The MBC value in combination ethyl acetate-water at 25 mg/ml, combination hexane-ethyl acetate and hexane-water MBC value at 50 mg/ml and 100 mg/ml. Based on optical density measurement using ELISA reader and bacterial growth on the media used, the fraction combinations increase the antibacterial effect of Uncaria gambier against E. faecalis ATCC 29212. Conclusion: The combination of various Uncaria gambier solvents has been shown to inhibit and kill E. faecalis (ATCC 29212). The combination of ethyl acetate-water fraction is the best combination to against E. faecalis (ATCC 29212). It means that the combination of various Uncaria gambier solvents can be developed as alternative root canal irrigation.

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“…Extratos das folhas e frutos M. africana foram analisados frente aos seus potenciais anticancerígeno, obtendo resultados promissores in vitro contra linhagens de células cancerígenas humanas. Quando comparados os dois extratos da espécie a amostra dos frutos de M. africana apresentou melhor atividade antitumoral, quando comparada com o extrato das folhas (LARAIB et al, 2021).…”

Section: Inibição De Crescimento (%)unclassified

“…Os extratos das folhas e frutos de M. africana mostraram-se promissores contra os radicais de peróxido de hidrogênio e superóxido. O mirsinosídeo B, um composto encontrado nesta espécie, foi testado isoladamente para análise da redução da atividade de peróxido de hidrogênio e superóxido 5-lipoxigenase, que resultou na capacidade de combater os radicais livres (FIBRICH et al, 2020;LARAIB et al, 2021;GUL et al, 2021).…”

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Determinação da atividade antitirosinase e antioxidante de >i<Myrsine coriacea>/i< (Sw.) R. Br. ex Roem. & Schult. (Primulaceae)

Almeida¹

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Agradeço primeiramente à Deus, pela dádiva da vida, por sua presença em toda jornada deste trabalho, me fortalecendo emocionalmente, iluminando e guiando meu caminho. Ao professor Dr. Paulo R. H. Moreno, por me acolher em seu laboratório, por compartilhar seus conhecimentos, pela sua ajuda nos experimentos como na escrita, pela paciência, dedicação, compreensão e orientação na realização deste trabalho. À professora Dra. Elfriede Marianne Bacchi (in memoriam), pelos seus ensinamentos, conversas e apoio, sempre lembrarei com muito carinho. À professora Dra. Fabiana Lima Silva, pela ajuda nos experimentos, conhecimento transmitido e prestatividade. À pós-graduanda Paula Rezende Teixeira do Laboratório de Farmacologia de Produtos Naturais Marinhos (LAFARMAR), pela realização dos ensaios de avaliação da citotoxicidade das amostras. Aos meus pais e familiares, em especial à madrinha Rosa e tia Terezinha, por todo amor, pelas orações e todo apoio. Sou eternamente grata a vocês! Ao Igor Ruschi, meu companheiro, meu esposo e amigo, gratidão pelo seu apoio, pela sua colaboração nos ensaios in silico, pela ajuda neste trabalho, por todo seu amor e presença. À minha filha Alice, que nasceu durante o mestrado e me fez renascer, me deu forças e um amor incondicional. Ela desperta meu melhor sorriso.

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Phytochemical Analysis and Some Bioactivities of Leaves and Fruits of Myrsine africana Linn

Cited by 10 publications

References 24 publications

Methanolic Extract of Myrsine africana Leaf Ameliorates Hyperglycemia and Dyslipidemia in Alloxan-Induced Diabetic Albino Mice

Methanolic Extract of Myrsine africana Leaf Ameliorates Hyperglycemia and Dyslipidemia in Alloxan-Induced Diabetic Albino Mice

Antimicrobial properties of various solvents combinations for phytochemical fraction derived from Uncaria gambier extract against Enterococcus faecalis ATCC 29212

Determinação da atividade antitirosinase e antioxidante de >i<Myrsine coriacea>/i< (Sw.) R. Br. ex Roem. & Schult. (Primulaceae)

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