Due to environmental changes, the self-defense mechanism can be found in bioactive compounds production. As a potential resource, the activity of bioactive compounds contained in mangroves can produce a variety of natural products that are widely used in pharmaceuticals and food supplements. 3 Secondary metabolites in mangrove plants include alkaloids, phenolics, steroids, terpenoids, and other compounds. 8 These compounds have important toxic, pharmacological, and ecological effects. 5 Mangrove plant extracts show biological activities such as antioxidants, antibacterials, and antimalarials. 9 The activity of antioxidant compounds can play a role in inhibiting free radicals that cause cell damage or slow oxidation reactions, even at small concentrations. Because of its association with beneficial health effects against a variety of diseases, there has been an increase in interest in the application of this antioxidant in the field of medicine in recent years, such as cardiovascular, cancer, cataract, atherosclerosis, retinopathy, arthritis, emphysema, and neuro-degenerative. 10 In addition, natural antioxidant compounds are significant in the health sector and have a direct effect on the food industry as natural preservatives for food products.Research on the activity of bioactive compounds in mangrove leaves has been carried out in recent years, phytochemical content and toxicity effects to Avicennia marina, 7 and utilization of mangrove leaf extract of Bruguiera gymnorrhiza with various solvents has been studied as an antibacterial, antifungal, and antioxidant. 11 antioxidant activity of from Sonneratia caseolaris extract has been studied as super antioxidant. 12 Moreover, the phenolic properties of mangrove plants and the activity of their strong bioactive compounds have been discussed in many studies. However, polycyclic aromatic hydrocarbons (PAHs) have caused organic contamination in the Tanjung Api-Api Port area.