Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Ptychotis verticillata Duby: Anti-diabetic, anti-tyrosinase, and anti-inflammatory activity

Taibi, Mohamed; Elbouzidi, Amine; Haddou, Mounir; Baraich, Abdellah; Loukili, El Hassania; Moubchir, Tarik; Allali, Aimad; Amine khoulati,; Bellaouchi, Reda; Asehraou, Abdeslam; Addi, Mohamed; Salamatullah, Ahmad Mohammad; Bourhia, Mohammed; Siddique, Farhan; El Guerrouj, Bouchra; Chaabane, Khalid

doi:10.1016/j.heliyon.2024.e29459

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e29459

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Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Ptychotis verticillata Duby: Anti-diabetic, anti-tyrosinase, and anti-inflammatory activity

Mohamed Taibi,

Amine Elbouzidi,

Mounir Haddou

et al.

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Cited by 4 publications

References 72 publications

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Investigating the antidiabetic properties of Apium graveolens extract and its inhibition of enzymes associated with hyperglycemia

Assaggaf

2025

International Journal of Biological Macromolecules

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Investigating the antidiabetic properties of Apium graveolens extract and its inhibition of enzymes associated with hyperglycemia

Assaggaf

2025

International Journal of Biological Macromolecules

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Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Clinopodium nepeta subsp. ascendens : potential for the food and pharmaceutical sectors

Taibi,

Elbouzidi,

Haddou

et al. 2024

CyTA - Journal of Food

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Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer Lines

Taibi,

Elbouzidi,

Haddou

et al. 2024

Life

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The objective of this study was to evaluate the antioxidant, anti-inflammatory, and anticancer properties of thymol, carvacrol, and their equimolar mixture. Antioxidant activities were assessed using the DPPH, ABTS, and ORAC methods. The thymol/carvacrol mixture exhibited significant synergism, surpassing the individual compounds and ascorbic acid in DPPH (IC50 = 43.82 ± 2.41 µg/mL) and ABTS (IC50 = 23.29 ± 0.71 µg/mL) assays. Anti-inflammatory activity was evaluated by inhibiting the 5-LOX, COX-1, and COX-2 enzymes. The equimolar mixture showed the strongest inhibition of 5-LOX (IC50 = 8.46 ± 0.92 µg/mL) and substantial inhibition of COX-1 (IC50 = 15.23 ± 2.34 µg/mL) and COX-2 (IC50 = 14.53 ± 2.42 µg/mL), indicating a synergistic effect. Anticancer activity was tested on MCF-7, MDA-MB-231, and MDA-MB-436 breast cancer cell lines using the MTT assay. The thymol/carvacrol mixture demonstrated superior cytotoxicity (IC50 = 0.92–1.70 µg/mL) and increased selectivity compared to cisplatin, with high selectivity indices (144.88–267.71). These results underscore the promising therapeutic potential of the thymol/carvacrol combination, particularly for its synergistic antioxidant, anti-inflammatory, and anticancer properties against breast cancer. This study paves the way for developing natural therapies against breast cancer and other conditions associated with oxidative stress and inflammation, leveraging the synergistic effects of natural compounds like thymol and carvacrol.

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Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Ptychotis verticillata Duby: Anti-diabetic, anti-tyrosinase, and anti-inflammatory activity

Cited by 4 publications

References 72 publications

Investigating the antidiabetic properties of Apium graveolens extract and its inhibition of enzymes associated with hyperglycemia

Investigating the antidiabetic properties of Apium graveolens extract and its inhibition of enzymes associated with hyperglycemia

Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Clinopodium nepeta subsp. ascendens : potential for the food and pharmaceutical sectors

Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer Lines

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