Phytochemical composition and biological activities of Asteriscus graveolens (Forssk) extracts

Ramdane, Farah; Hammi, Khaoula Mkadmini; Hammami, Majdi; Farès, Nadia; Mahammed, Mahfoud Hadj; Ouassis, Dahmane El; Tabbene, Olfa; Limam, Férid; Hadj, Mohamed Didi Ould El

doi:10.1016/j.procbio.2017.03.004

Cited by 37 publications

(23 citation statements)

References 46 publications

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“…Similar results were reported by Lébri et al (2015) in Ivory Coast for Abrus precatorius and by Agbankpé et al (2015) in Benin for Vernonia amygdalina. However, quantitative analysis is still required for confirmation following Medoatinsa et al (2016) and Ramdane et al (2017). The difference of relative concentration of these phytochemical elements observed, if confirmed, could be due to climate, soil, physiological stages of the plant growth or the genotypes of the plants sampled.…”

Section: Phytochemical Screeningmentioning

confidence: 93%

Phytochemical Screening and Toxicity of Lippia multiflora Moldenke, a Minor Aromatic Leafy Vegetable Consumed in Benin

Djengue¹,

Dansi²,

Assogba³

et al. 2017

Int. J. Curr. Res. Biosci. Plant Biol.

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A b s t r a c t A r t i c l e I n f oLippia multiflora Moldenke, is a minor aromatic leafy vegetable mainly consumed in central Benin that belong to the country's neglected and underutilised species (NUS). Extracts of its leaves and flowers collected from six different zones (Bantè, Dassa-Zoumè, Djidja, Glazoué, Savalou and Savè) were assessed for phytochemical composition and tested for cytotoxicity using brine shrimp lethality bioassay. The phytochemical screening revealed the presence of almost the same phytochemical groups (cathetic and gallic tannins, flavonoids, anthocyanins, leucoanthocyanes, triterpenoids, mucilage, coumarins and the reducing compounds) in both leaves and flowers from all sites with variable abundances. Alkaloids were found only in leaves while steroids, quinone derivatives and combined anthracene C-heterosides were identified uniquely in flowers. The nature and the functions of the compounds found justify the perceived medicinal values of the species. Extracts from both leaves and flowers showed positive action on shrimp larvae but with CL 50 of (13.28±1.52 mg/ml for leaves; 0.46±0.05 mg/ml for flowers) superior to 0.1mg/ml, hence indicating the non-toxicity of Lippia multiflora.

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Section: Phytochemical Screeningmentioning

confidence: 93%

Phytochemical Screening and Toxicity of Lippia multiflora Moldenke, a Minor Aromatic Leafy Vegetable Consumed in Benin

Djengue¹,

Dansi²,

Assogba³

et al. 2017

Int. J. Curr. Res. Biosci. Plant Biol.

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“…The medium was aspirated off and replaced by 100 µL of various concentrations of tested samples; viability was evaluated using the MTT method after 72 hours of incubation. 19,20 The supernatant was conserved for the nitrite assay at −20°C.…”

Section: Cytotoxicity and Selectivity Index (Si)mentioning

confidence: 99%

Antileishmanial Potential of Propolis Essential Oil and Its Synergistic Combination With Amphotericin B

Jihene

Ines

Hammami

et al. 2020

Natural Product Communications

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The antileishmanial activity of Tunisian propolis essential oil (EO) and its combination with amphotericin B was investigated against 2 local clinical strains of Leishmania: Leishmania major and Leishmania infantum. The cytotoxic potential of this EO was evaluated against macrophage Raw264.7. Combination of propolis EO and amphotericin B was investigated using the checkerboard method. The propolis sample was collected from the region of Beni Khalled, a Tunisian city located west of Cape Bon (Nabeul). Its location is particular since it is near to sea with a steppe climate and the predominance of citrus trees. The EO was obtained by Clevenger-type apparatus. Its chemical composition was identified using gas chromatography with flame ionization detector and gas chromatography-mass spectrometry analysis. Our results demonstrate that Tunisian propolis EO exhibit good antileishmanial activity against L. major and L. infantum promastigotes (IC50 = 5.29 ± 0.31 and 3.67 ± 0.52 µg/mL, respectively) and amastigotes (IC50 = 7.38 ± 0.45 and 4.96 ± 0.24 µg/mL, respectively). Moreover, it reduced significantly the parasite proliferation on a dose-dependent response (95%) with low cytotoxicity (selectivity index = 16.18 and 23.33, respectively). Its combination with amphotericin B showed a synergistic potential (fractional inhibitory concentration = 0.37). Interestingly, the data suggest that propolis EO was involved in macrophage activation by hyperproduction of NO. A total of 51 compounds were identified in the propolis EO. The major compound identified was α-pinene (36.7% ± 2.36%) followed by α-cedrol (6.7% ± 0.10%), totarol (6.6% ± 0.09%), and dehydroabietane (5.2% ± 0.10%). Our findings suggest that Tunisian propolis might constitute a promising source for antileishmanial molecules.

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“…After 72 h of incubation at 37°C, viability was estimated by MTT test as described above and selectivity index (SI) was determined as the ratio of IC 50 macrophage/IC 50 parasite. 67,68 The results were expressed as mean ± standard deviation (SD) and statistically analyzed using Student's t-test by Microsoft Excel software. Differences were considered significant at P <0.05.…”

Section: Antileishmanial Activitymentioning

confidence: 99%

Acid-activated clay as heterogeneous and reusable catalyst for the synthesis ofbioactive cyclic ketal derivatives

Hagui¹,

Amri²,

Farès³

et al. 2019

Turk J Chem

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A new heterogeneous acid catalyst based on a natural resource, Tunisian clay (Clay-H0.5), has been prepared and characterized by FT-IR, FE-SEM, and powder X-ray diffraction (XRD), as well as chemical composition, cation exchange capacity, specific surface area, and pore volume. Acid treatment for 0.5 h enlarged the surface area from 78.24 to 186.10 m 2 /g and pore volume (PV) from 0.186 to 0.281 cm 3 /g. The catalytic activity of this material was investigated in ketalization reaction under mild solvent-free conditions. This achieved up to 92% isolated yield for only 10 wt.% of the catalyst. This environmentally friendly method has advantages such as simple work-up procedure, avoidance of organic solvents, and good performance in ketalization reactions. Importantly, the Clay-H0.5 catalyst showed good recyclability where insignificant activity loss was exhibited even after six runs. Synthesized cyclic ketals were tested for their possible antileishmanial and antibacterial activities as well as antifungal activity. Biological screening showed that compound 11 had important antileishmanial activity against both L. major and L. infantum, while compound 14 also had significant antibacterial activity against four gram-positive and two gram-negative bacteria, and antifungal activity against Candida albicans, with minimal inhibitory concentration values ranging from 15.62 µg/mL to 125 µg/mL.

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Phytochemical composition and biological activities of Asteriscus graveolens (Forssk) extracts

Cited by 37 publications

References 46 publications

Phytochemical Screening and Toxicity of Lippia multiflora Moldenke, a Minor Aromatic Leafy Vegetable Consumed in Benin

Phytochemical Screening and Toxicity of Lippia multiflora Moldenke, a Minor Aromatic Leafy Vegetable Consumed in Benin

Antileishmanial Potential of Propolis Essential Oil and Its Synergistic Combination With Amphotericin B

Acid-activated clay as heterogeneous and reusable catalyst for the synthesis ofbioactive cyclic ketal derivatives

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