Phytochemical Composition, Antioxidant Potential, and Medicinal Significance of <i>Ficus</i>

Nawaz, Haq; Waheed, Rashem; Nawaz, Mubashir

doi:10.5772/intechopen.86562

Cited by 22 publications

(12 citation statements)

References 62 publications

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“…These phytochemicals in F. vasta extract may play a part in its therapeutic benefits. Ficus genus is medically important due to the presence of high value of total bioactive contents (TPC and TFC) [ 62 ]. Previously, some flavonoid compounds were identified in leaves of F. vasta [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Profiling, In Vitro Biological Activities, and In-Silico Studies of Ficus vasta Forssk.: An Unexplored Plant

et al. 2022

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Ficus vasta Forssk. (Moraceae family) is an important medicinal plant that has not been previously investigated for its phytochemical and biological potential. Phytochemical screening, total bioactive content, and GCMS analysis were used to determine its phytoconstituents profile. Antioxidant, antibacterial, antifungal, anti-viral, cytotoxicity, thrombolytic, and enzyme inhibition activities were examined for biological evaluation. The plant extract exhibited the maximum total phenolic (89.47 ± 3.21 mg GAE/g) and total flavonoid contents (129.2 ± 4.14 mg QE/g), which may be related to the higher antioxidant potential of the extract. The extract showed strong α-amylase (IC50 5 ± 0.21 µg/mL) and α-glucosidase inhibition activity (IC50 5 ± 0.32 µg/mL). Significant results were observed in the case of antibacterial, antifungal, and anti-viral activities. The F. vasta extract inhibited the growth of HepG2 cells in a dose-dependent manner. The GCMS analysis of the extract provided the preliminary identification of 28 phytocompounds. In addition, the compounds identified by GCMS were subjected to in silico molecular docking analysis in order to identify any interactions between the compounds and enzymes (α-amylase and α-glucosidase). After that, the best-docked compounds were subjected to ADMET studies which provide information on pharmacokinetics, drug-likeness, physicochemical properties, and toxicity. The present study highlighted that the ethanol extract of F. vasta has antidiabetic, antimicrobial, anti-viral, and anti-cancer potentials that can be further explored for novel drug development.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Profiling, In Vitro Biological Activities, and In-Silico Studies of Ficus vasta Forssk.: An Unexplored Plant

et al. 2022

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“…Various Ficus species have been used as traditional medicines to cure diseases, such as, astringents carminatives, stomachic, vermicides, hypotensive, anthelmintic and anti-dysentery drugs (Trivedi et al 1969) [11] . Ficus species, such as, Ficus amplissima (Karuppusamy et al 2013) [6] , F. racemosa, F. glomerata, F. glumosa, F. carica, F. religiosa and F. benghalensis (Haq Nawaz et al 2019) [5] are known from ancient times as herbal medicines to treat various ailments in human beings. (Deepa, et al 2018) [4] .…”

Section: Introductionmentioning

confidence: 99%

Preliminary phytochemical analysis of Ficus johanis Subsp. afghanistanica from Moraceae family

Tadavi¹,

Dafare²,

Zanje³

et al. 2023

J Pharmacogn Phytochem

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“…Species of Ficus are known to possess antioxidant, cytotoxic, antimicrobial, anti-inflammatory, antidiabetic, antiulcer, and anticonvulsant activities (Salehi et al, 2021). Phytochemicals such as genistein, protocatechuic acid, stigmatserol, rutin, bergapten, psoralen, alpinumisoflavone, betulinic acid, umbelliferone, apigenin, derrone, β-sistosterol and chlorogenic acid, amongst others, were common compounds reported in this genus (Nawaz, et al, 2019;Ateba et al, 2019). A recent study on the phytochemical screening of F. sagittifolia leaf and stem bark extracts revealed the presence of phenolics, flavonoids, steroids, tannins, saponins, alkaloids, and terpenoids with good antioxidant activities (Taiwo and Olaoluwa, 2020).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Constituents of F. Sagittifolia Warburg ex Mildbraed & Burret Leaves with Antimicrobial Activity

et al. 2022

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The leaves and bark of Ficus sagittifolia have been used as a cure for stomach and pulmonary disorders, respectively. The bark is edible and is taken against colic. From the leaves of F. sagittifolia, a steroidal glycoside named Stigmast-5,22-diene-3-O-β-D-glucopyranoside 1 and three isoflavonoids named 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one 2, 5-hydroxy-3(4-hydroxylphenyl)-8,8-dimethylpyrano[2,3-f]-chromen-4(8H)-one 3 and 5-hydroxy-3-(4-hydroxyphemyl)-8,8-dimethylpyrano[3,2-g}-chromen-4(8H)-one 4 were isolated, and this is the first report of the isolation of these compounds from this plant. The structural elucidation of the compounds was based on 1D and 2D NMR, IR and MS data analyses. Compounds 1 and 2 inhibited the growth of Pseudomonas aeruginosa and Aspergillus Niger at 6.25 mg/mL, respectively while compounds 2 and 4 were active against Helicobacter pylori at 6.25 mg/mL. These findings corroborate the ethno-medicinal use of F. sagittifolia leaves as a treatment for stomach disorders.

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Phytochemical Composition, Antioxidant Potential, and Medicinal Significance of Ficus

Cited by 22 publications

References 62 publications

Phytochemical Profiling, In Vitro Biological Activities, and In-Silico Studies of Ficus vasta Forssk.: An Unexplored Plant

Phytochemical Profiling, In Vitro Biological Activities, and In-Silico Studies of Ficus vasta Forssk.: An Unexplored Plant

Preliminary phytochemical analysis of Ficus johanis Subsp. afghanistanica from Moraceae family

Phytochemical Constituents of F. Sagittifolia Warburg ex Mildbraed & Burret Leaves with Antimicrobial Activity

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