Phytochemical Compounds Loaded to Nanocarriers as Potential Therapeutic Substances for Alzheimer’s Disease-Could They be Effective?

Abstract

Alzheimer’s disease accounts for high percentages of dementia cases in elderly individuals. This type of brain disease is caused by damage of the brain cells affecting the ability of the patients to communicate, as well as their thinking, behavior, and feelings. Although numerous research laboratories focus on advancements for the treatment of Alzheimer’s disease, the currently approved pharmacological approaches seem to only alleviate the symptoms. Consequently, there is an urgent need for alternative pharmacological options which can prevent the progressive impairment of neurons. Natural substances were used from ancient times for the treatment of various disorders given their biological activities such as antioxidant, anti-inflammatory, and antiapoptotic properties. Besides, their cost-effectiveness as well as their accessibility to anyone who needs them, are their most significant characteristics. Therefore, the possible use of phytochemical compounds for the possible management or even prevention of Alzheimer’s disease is currently under investigation. In this review article, the present status of Alzheimer’s disease diagnosis and underlying mechanisms, the potential phytochemicals, and their carriers along with future perspectives are summarized. It is suggested that in the future natural substances can play a role as an adjunct therapy for neurodegenerative forms of dementia, such as Alzheimer’s disease.