Phytochemical Evaluation and Antioxidant Activity of Essential Oil, and Aqueous and Organic Extracts of Artemisia dracunculus

Rajabian, Arezoo; Khayyat, Mohamad Hassanzadeh; Emami, Seyed Ahmad; Tayarani‐Najaran, Zahra; Oskooie, Reza Rahimzadeh; Asili, Javad

doi:10.17795/jjnpp-32325

Cited by 6 publications

(8 citation statements)

References 31 publications

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“…Overall, according to the three tests used in this study (ABTS radical scavenging activity, Reducing power and Phosphomolybdenum assay), the obtained antioxidant activity of the RaEO might be attributed to the presence of high percentages of mainly germacrene D (49.2 ± 1.1%), methyl eugenol (8.3 ± 0.28%), (E)-β-ionone (6.2 ± 0.18%) and β-caryophyllene (5.7 ± 0.17%) (Table 1 ). Similarly to our results, some works reported that several essential oils having low phenolic compounds amounts also exhibits interesting antioxidant capacity [ 43 , 44 ]. However, it’s difficult to correlate the antioxidant activity of a total essential oil to one or few active compounds.…”

Section: Discussionsupporting

confidence: 91%

Rhaponticum acaule (L) DC essential oil: chemical composition, in vitro antioxidant and enzyme inhibition properties

Mosbah

Chahdoura

Kammoun³

et al. 2018

BMC Complement Altern Med

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Backgroundα-glucosidase is a therapeutic target for diabetes mellitus (DM) and α-glucosidase inhibitors play a vital role in the treatments for the disease. Furthermore, xanthine oxidase (XO) is a key enzyme that catalyzes hypoxanthine and xanthine to uric acid which at high levels can lead to hyperuricemia which is an important cause of gout. Pancreatic lipase (PL) secreted into the duodenum plays a key role in the digestion and absorption of fats. For its importance in lipid digestion, PL represents an attractive target for obesity prevention.MethodsThe flowers essential oil of Rhaponticum acaule (L) DC (R. acaule) was characterized using gas chromatography-mass spectrometry (GC-MS). The antioxidant activities of R. acaule essential oil (RaEO) were also determined using 2,2’-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), reducing power, phosphomolybdenum, and DNA nicking assays. The inhibitory power of RaEO against α-glucosidase, xanthine oxidase and pancreatic lipase was evaluated. Enzyme kinetic studies using Michaelis-Menten and the derived Lineweaver-Burk (LB) plots were performed to understand the possible mechanism of inhibition exercised by the components of this essential oil.ResultsThe result revealed the presence of 26 compounds (97.4%). The main constituents include germacrene D (49.2%), methyl eugenol (8.3%), (E)-β-ionone (6.2%), β-caryophyllene (5.7%), (E,E)-α-farnesene (4.2%), bicyclogermacrene (4.1%) and (Z)-α-bisabolene (3.7%). The kinetic inhibition study showed that the essential oil demonstrated a strong α-glucosidase inhibiton and it was a mixed inhibitor. On the other hand, our results evidenced that this oil exhibited important xanthine oxidase inhibitory effect, behaving as a non-competitive inhibitor. The essential oil inhibited the turkey pancreatic lipase, with maximum inhibition of 80% achieved at 2 mg/mL. Furthermore, the inhibition of turkey pancreatic lipase by RaEO was an irreversible one.ConclusionThe results revealed that the RaEO is a new promising potential source of antioxidant compounds, endowed with good practical applications for human health.

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Section: Discussionsupporting

confidence: 91%

Rhaponticum acaule (L) DC essential oil: chemical composition, in vitro antioxidant and enzyme inhibition properties

Mosbah

Chahdoura

Kammoun³

et al. 2018

BMC Complement Altern Med

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“…Both assays identified the EO and estragole (2) as weaker antioxidants than BHT and vitamin E, and compound 2 was less active than the EO. 20 In addition to the beneficial antioxidant properties, there are data, although contradictory, that allylpolyalkoxybenzenes exhibit genotoxic effects. Estragole (2), methyl eugenol (3), safrole (4), myristicin (5), apiol (7), and dillapiol (8) were reported to form DNA adducts in HepG2 human hepatoma cells, which may cause mutations, eventually leading to carcinogenesis.…”

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confidence: 99%

Antioxidant Activity of Natural Allylpolyalkoxybenzene Plant Essential Oil Constituents

et al. 2019

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Free-radical-scavenging capacity antioxidant and membrane-protective properties of natural and related synthetic allylpolyalkoxybenzenes with different numbers of alkoxy/methoxy groups in the aromatic ring were evaluated using several in vitro models. These included the DPPH assay, inhibition of lipid peroxidation products accumulation, inhibition of H 2 O 2 -induced hemolysis, and oxidation of oxyhemoglobin. A synthetic protocol for the synthesis of natural nothoapiol (9) from a parsley seed metabolite, apiol (7), was developed. A structure−activity relationship study revealed that both the methylenedioxy fragment and methoxy groups in the aromatic ring are favorable for antioxidant activity. Hydroxyapiol ( 14), containing a hydroxy group in the aromatic core, was identified as the most potent compound. The pentaalkoxy-substituted nothoapiol (9) showed antioxidant activity in mouse brain homogenates, whereas in mouse erythrocytes it exhibited a marked pro-oxidant effect. Despite their low free-radical-scavenging capacity, allylpolyalkoxybenzenes can contribute to the total antioxidant potencies of plant essential oils.

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“…These results are in agreement with the antioxidant activity of tarragon reported previously. 7,8,32 Tarragon essential oil collected from Tajikistan demonstrated only very weak antibacterial activity against both Grampositive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Study on the Essential Oils of Tarragon (Аrtemisia dracunculus L.) Growing in Tajikistan and Its Comparison With the Essential Oil of the Species in the Rest of the World

Sharopov

Salimov²,

Numonov

et al. 2020

Natural Product Communications

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The aerial parts of the tarragon ( Artemisia dracunculus) were collected around Kukteppa village, Ziddi, Varzob region of Tajikistan. The essential oil of tarragon was obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry. Forty-five compounds representing 99.8% of total oil were identified. Sabinene (29.1%), estragole (24.6%), limonene (7.8%), ( Z)-artemidin (4.9%), myrcene (4.8%), and ( E)-β-ocimene (4.0%) were components with a representation higher than 4% of the essential oils of aerial parts of tarragon. Hierarchical cluster analysis of А. dracunculus essential oils on the global phytogeographic origin based on 30 essential oil components and 105 samples (globally) of this species, indicated the existence of its 7 major chemotypes: ocimene, α-terpinene, capillene, methyl eugenol, mixed chemotype, ( Z)-artemidin, and estragol chemotypes. The essential oils of А. dracunculus showed weak antioxidant and antibacterial activities. To our best knowledge, this is the first report concerning the chemical composition, chemotypic variation, antioxidant, and antimicrobial activities of the essential oils obtained from the aerial parts of А. dracunculus, growing wild in the Varzob region of Tajikistan.

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Phytochemical Evaluation and Antioxidant Activity of Essential Oil, and Aqueous and Organic Extracts of Artemisia dracunculus

Abstract: Background: The genus Artemisia has various medicinal effects. Artemisia dracunculus (tarragon) is one of the species that belongs to the genus Artemisia, cultivated in Iran.

Cited by 6 publications

References 31 publications

Rhaponticum acaule (L) DC essential oil: chemical composition, in vitro antioxidant and enzyme inhibition properties

Rhaponticum acaule (L) DC essential oil: chemical composition, in vitro antioxidant and enzyme inhibition properties

Antioxidant Activity of Natural Allylpolyalkoxybenzene Plant Essential Oil Constituents

Phytochemical Study on the Essential Oils of Tarragon (Аrtemisia dracunculus L.) Growing in Tajikistan and Its Comparison With the Essential Oil of the Species in the Rest of the World

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