Phytochemical investigation using GC/MS analysis and evaluation of antimicrobial and cytotoxic activities of the lipoidal matter of leaves of Sophora secundiflora and Sophora tomentosa

Hussiny, Shaza; Elissawy, Ahmed M.; Eldahshan, Omayma A.; Elshanawany, Mohamed M.; Singab, Abdel-Nasser

doi:10.21608/aps.2020.38371.1039

Cited by 10 publications

(16 citation statements)

References 30 publications

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“…tonkinensis S. japonica S. secundiflora S. interrupta Roots Leaves Leaves/Branches Flowers Aerial parts Roots Aly et al ( 2019 ), Chang et al ( 2018 ) Antipsoriatic Aly et al ( 2019 ), Boozari et al ( 2019b ) Anti-inflammatory Aly et al ( 2017 , 2020a , b , c ), Boozari et al ( 2019b ), Elberry et al ( 2020 ), Cho et al ( 2020 ), Li et al ( 2019c , 2020b ), Rammohan et al ( 2020 ), Ye et al ( 2020 ) Anti-arthritic S. flavescens Aerial parts/Roots Ao et al ( 2019 ), Elberry et al ( 2020 ) Anti-osteoporosis S. flavescens Fruits/Aerial parts Li et al ( 2020d ), Mao et al ( 2020 ), Yang et al ( 2020c ) Nematicidal S. flavescens Aerial parts Aly et al ( 2019 ) Anti-parasitic S. moorcroftiana Aerial parts Luo et al ( 2018 ) Insecticidal S. alopecuroides Aerial parts Boozari et al ( 2019b ), Zhang et al ( 2020a , b , c ), Zhou et al ( ...…”

Section: Biological Effectsmentioning

confidence: 99%

“…The lipoidal matters were reported with in vitro cytotoxic activity towards HCT-116 carcinoma cell line (IC 50 -value of 97.00 and 38.76 μg mL −1 for S. secundiflora and S. tomentosa, respectively) using the MTT assay (Aly et al 2020a ). Palmitic acid 346 is the major saturated fatty acid in both lipoidal matters; it showed anti-inflammatory and selective cytotoxic activity towards the human leukemia cell line MOLT-4.…”

Section: Biological Effectsmentioning

confidence: 99%

“… Name Plant species Structure References 217 β-Sitosterol S. alopecuroides S. mollis S. secundiflora S. tomentosa Aly et al ( 2020a ), Wang et al ( 2020b ) 218 Sitosterol 3- O -glucoside S. mollis S. pachycarpa Boozari et al ( 2019a ), Quradha et al ( 2021 ) 219 Stigmasterol S. secundiflora S. tomentosa Aly et al ( 2020a ) 220 Stigmasterol 3- O -glucoside S. alopecuroides S. pachycarpa Wang et al ( 2020b ) 221 Campesterol S. secundiflora S. tomentosa Aly et al ( 2020a ) 222 Lup-20(29)-ene-3, 28- diol (Betulin) S. mollis S. tomentosa S. secundiflora Aly et al ( 2020a ), Quradha et al ( 2021 ) …”

Section: Introductionunclassified

“… Name Plant species Structure References 223 Soyasaponin I methyl ester S. flavescens S. japonica S. subprostrata 223 : R = S1 224 : R = S2 Yang et al ( 2020b ) 224 Soyasaponin II methyl ester 225 Kaikasaponin III methyl ester S. subprostrata 225 : R = S1 226 : R = S3 Yang et al ( 2020b ) 226 Kaikasaponin I methyl ester 227 Soyasaponin A 3 methyl ester S. subprostrata 227 : R = CH 3 228 : R = CH 2 OH Yang et al ( 2020b ) 228 Kuzusapogenol A methyl ester 229 Lupeol S. flavescens S. japonica S. subprostrata Wang et al ( 2020b ) 230 α-Amyrin S. tomenosa S. secundiflora Aly et al ( 2020a ) 231 β-Amyrin acetate S. tomenosa S. secundiflora Aly et al ( 2020a ) …”

Section: Introductionmentioning

confidence: 99%

“…Another example about the roots of S. subprostrata and S. mollis , which were used as an antipyretic, analgesic with a potential anti-tumor activity (Ao et al 2019 ; Wang et al 2019a ; Zhang et al 2020a ; Quradha et al 2021 ). These roots are also used as a Korean traditional medicine for the treatment of fever, inflammation, peptic ulcer, and cancer (Aly et al 2019 , 2020a ; Boozari et al 2019b ; Chen et al 2020b ; Wang et al 2020b ; Yang et al 2020b ). Several Sophora species including S. subprostrata displayed various activities in dispelling dampness, clearing heat, sedation, detoxification, and relieving swelling and pain (Zhou et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives

2021

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Sophora is deemed as one of the most remarkable genera of Fabaceae, and the third largest family of flowering plants. The genus Sophora comprises approximately 52 species, 19 varieties, and 7 forms that are widely distributed in Asia and mildly in Africa. Sophora species are recognized to be substantial sources of broad spectrum biopertinent secondary metabolites namely flavonoids, isoflavonoids, chalcones, chromones, pterocarpans, coumarins, benzofuran derivatives, sterols, saponins (mainly triterpene glycosides), oligostilbenes, and mainly alkaloids. Meanwhile, extracts and isolated compounds from Sophora have been identified to possess several health-promising effects including anti-inflammatory, anti-arthritic, antiplatelets, antipyretic, anticancer, antiviral, antimicrobial, antioxidant, anti-osteoporosis, anti-ulcerative colitis, antidiabetic, anti-obesity, antidiarrheal, and insecticidal activities. Herein, the present review aims to provide comprehensive details about the phytochemicals and biological effects of Sophora species. The review spotlighted on the promising phytonutrients extracted from Sophora and their plethora of bioactivities. The review also clarifies the remaining gaps and thus qualifies and supplies a platform for further investigations of these compounds.

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Section: Biological Effectsmentioning

confidence: 99%

Section: Biological Effectsmentioning

confidence: 99%

Section: Introductionunclassified

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives

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Small Steps to the Big Picture for Health‐Promoting Applications Through the Use of Chickweed (Stellaria media): In Vitro, In Silico, and Pharmacological Network Approaches

Cusumano,

Flores,

Cetiz

et al. 2024

Food Science & Nutrition

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Stellaria media L., also called chickweed, is widespread in all parts of the world. In the present study, we investigated the biological properties and chemical profiles of different extracts (ethyl acetate, ethanol, ethanol/water, and water) of S. media. The chemical profiles were examined using UHPLC/MS/MS technique. Regarding the biological properties, antioxidant properties as well as enzyme‐inhibiting and cytotoxic effects of the extracts were demonstrated by in vitro methods. To obtain further information about the structure‐ability relationship, network pharmacology and molecular docking were also performed. Twelve phenolic compounds were identified in the extracts and most of them were flavonoids (apigenin, kaempferol derivatives, etc.). The water extract showed the best free radical scavenging activity, while the ethanol was the most active in reducing power tests. When inhibiting AChE, the ethyl acetate extract showed the best inhibitory effect. The water extract has a good cytotoxic effect on HepG2 (cell viability: 33.9% at a concentration of 100 g/mL). The analysis, performed using the STRING database, included these 45 cancer‐associated targets. The identified hub genes were TP53, CDKN2A, PTEN, KRAS, and HRAS. In molecular docking analysis, acacetin‐O‐hexoside‐O‐deoxyhexoside and napigenin‐7‐O‐hexoside exhibit remarkable binding energies with proteins. Consequently, S. media can be potential raw materials for designing functional formulations in the pharmaceutical, nutraceutical, and cosmeceutical industries.

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Unveiling the pharmacological potential of plant triterpenoids in breast cancer management: an updated review

Aly,

Elbadry,

Doghish

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Breast cancer is the most prevalent type of cancer, the fifth leading cause of cancer-related deaths, and the second leading cause of cancer deaths among women globally. Recent research has provided increasing support for the significance of phytochemicals, both dietary and non-dietary, particularly triterpenoids, in the mitigation and management of breast cancer. Recent studies showed that triterpenoids are promising agents in the treatment and inhibition of breast cancer achieved through the implementation of several molecular modes of action on breast cancer cells. This review discusses recent innovations in plant triterpenoids and their underlying mechanisms of action in combating breast cancer within the timeframe spanning from 2017 to 2023. The present work is an overview of different plant triterpenoids with significant inhibition on proliferation, migration, apoptosis resistance, tumor angiogenesis, or metastasis in various breast cancer cells. The anticancer impact of triterpenoids may be attributed to their antiproliferative activity interfering with angiogenesis and differentiation, regulation of apoptosis, DNA polymerase inhibition, change in signal transductions, and impeding metastasis. The present review focuses on several targets, mechanisms, and pathways associated with pentacyclic triterpenoids, which are responsible for their anticancer effects. We could conclude that natural triterpenoids are considered promising agents to conquer breast cancer. Graphical Abstract

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Phytochemical investigation using GC/MS analysis and evaluation of antimicrobial and cytotoxic activities of the lipoidal matter of leaves of Sophora secundiflora and Sophora tomentosa

Cited by 10 publications

References 30 publications

Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives

Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives

Small Steps to the Big Picture for Health‐Promoting Applications Through the Use of Chickweed (Stellaria media): In Vitro, In Silico, and Pharmacological Network Approaches

Unveiling the pharmacological potential of plant triterpenoids in breast cancer management: an updated review

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