Phytochemical portfolio and anticancer activity of Murraya koenigii and its primary active component, mahanine

Samanta, Suman Kumar; Kandimalla, Raghuram; Gogoi, Bhaskarjyoti; Dutta, Krishna Nayani; Choudhury, Paramita; Deb, Prashanta Kumar; Devi, Rajlakshmi; Pal, Buddhadev; Talukdar, Narayan Chandra

doi:10.1016/j.phrs.2017.11.024

Cited by 54 publications

(27 citation statements)

References 70 publications

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“…Several anticancer agents such as vinca alkaloids, podophyllotoxins, and campothecins are of plant origin [ 3 , 4 ]. Among these plant metabolites, alkaloids have been shown to exhibit a wide array of pharmacological properties such as anti-inflammatory, anticancer, and antimicrobial effects [ 5 , 6 ]. Mukonal is an important alkaloid that is mainly isolated from the plant Murraya koenigii [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activity of Mukonal Against Human Laryngeal Cancer Cells Involves Apoptosis, Cell Cycle Arrest, and Inhibition of PI3K/AKT and MEK/ERK Signalling Pathways

Binu

et al. 2018

Med Sci Monit

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BackgroundLaryngeal cancer is one of the major malignancies of the neck and head and is responsible for considerable mortality across the globe. The treatments for laryngeal cancer mainly involve surgical interventions followed by chemotherapy. However, due to unsatisfactory results, constant relapses and the adverse effects associated with the currently used drugs, there is pressing need to develop effective drug options for treatment of laryngeal cancer. Therefore, this study was undertaken to investigate the anticancer effects of a plant-derived alkaloid, Mukonal, against human AMC-HN-8 laryngeal cancer cells.Material/MethodsThe WST-1 and clonogenic assays were employed to determine the cell viability. Apoptosis was detected by Hoechst and AO/EB staining. Cell migration and cell cycle analysis was performed by Transwell assay and flow cytometry, respectively. Protein expression was examined by Western blotting.ResultsThe results revealed that Mukonal reduced the viability of laryngeal cancer cells dose-dependently. The IC50 of Mukonal was found to be 10 μM. However, the effects of Mukonal on the normal HuLa-PC cells was found to be 140 μM. The decrease in the viability of the AMC-HN-8 laryngeal cancer cells was found to be due to the induction of apoptosis and G2/M cell cycle arrest. Mukonal also suppressed the cell migration and of the AMC-HN-8 laryngeal cancer cells. Mukonal could also inhibit the PI3K/AKT and MEK/ERK signalling pathways in a concentration-dependent manner.ConclusionsTaken together, we conclude that Mukonal could prove a beneficial lead molecule for the treatment of laryngeal cancer.

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Section: Introductionmentioning

confidence: 99%

Anticancer Activity of Mukonal Against Human Laryngeal Cancer Cells Involves Apoptosis, Cell Cycle Arrest, and Inhibition of PI3K/AKT and MEK/ERK Signalling Pathways

Binu

et al. 2018

Med Sci Monit

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“…The plant is native to India and the most useful parts of the plant are the leaves, roots, and bark. In Ayurvedic medicine, this plant holds a significant position and shows several medicinal properties like anti‐diabetic, antioxidant, anti‐inflammatory, antimicrobial, anticarcinogenic, and hepatoprotective properties (Samanta et al, ). The nutrients found in the curry leaves are carbohydrates, fiber, calcium, iron, magnesium, copper, phosphorous, and minerals; and it also contains various vitamins like nicotinic acid and vitamin C, vitamin A, vitamin B, vitamin E, antioxidants, plant sterols, amino acids, glycosides, and flavonoids (Bonde, Nemade, Patel, & Patel, ).…”

Section: Discussionmentioning

confidence: 99%

“…A large number of phytoconstituents have been screened in this short model (Anchi et al, 2017). (Samanta et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Modulation of cerulein‐induced pancreatic inflammation by hydroalcoholic extract of curry leaf (Murraya koenigii)

Khurana

Sikha

Ramesh

et al. 2019

Phytotherapy Research

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This study was performed to study the in vitro and in vivo efficacy of hydroalcoholic extract of curry leaf (CLE) rich in carbazole alkaloids, against LPS‐induced inflammation in Raw 264.7 macrophages and cerulein‐induced acute pancreatitis, respectively. CLE was characterized by Fourier‐transform infrared (FTIR) and liquid chromatography–mass spectrometry. Raw 264.7 cells were stimulated with LPS (2 μg/ml) and treated with CLE. The animals were treated with two doses of CLE (100 and 300 mg/kg). Plasma biochemistry, tissue lipid peroxidation, cytokines, and histological examination were evaluated. CLE was found to decently scavenge the activity of DPPH radical. It dose dependently suppressed nitrite production and oxidative stress in macrophages. CLE alleviated LPS‐induced inflammation in macrophages as evident from the results of various inflammatory cytokines (IL‐1β, IL‐6, and TNF‐α). In vivo, CLE reduced cerulein‐induced pancreatic edema. CLE significantly abrogated the cerulein‐induced lipid peroxidation, nitrite, MPO, and GSH levels. The inflammatory cytokines and p65‐NFκB activity were significantly reduced by CLE. Mechanistically, CLE reduced the expression of NT, MPO, IL‐1β, ICAM‐1, and COX‐2, and increased the expression of Nrf2. It reduced distant organ damage markers as well. We report for the first time that CLE holds substantial potential for the prevention of acute pancreatitis.

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“…In the last two decades, numerous pre-clinical studies have documented the anti-proliferative activity of flavonoids, which has been largely linked to their abilities to interact with specific intracellular signalling pathways, in addition to their well-known antioxidant capacity (57,(59)(60)(61)(62)(63)(64). In this field, recently, we have reported the anti-cancer activity of Citrus bergamia (bergamot) juice (BJ) in different in vitro (65,66) and in vivo (67) models, and have proposed that its flavonoid content is responsible for this action (68).…”

Section: Discussionmentioning

confidence: 99%

Citrus fruits intake and oral cancer risk: A systematic review and meta-analysis

Cirmi

Navarra

Woodside

et al. 2018

Pharmacological Research

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Objective: To quantify the relationship between Citrus intake and risk of cancer of the oral cavity and pharynx.Design: Systematic review and meta-analysis. Data sources: Ovid MEDLINE, EMBASE, and Web of Science were searched until September 2017. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, Citrus oil, fruits, oral cancer, mouth cancer, mouth neoplasm. Study selection:The selection of studies and the systematic review were carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A pre-defined inclusion checklist resulted in the inclusion of articles which were (i) published in peer-reviewed scientific journals; (ii) English language; (iii) and included a measure of Citrus fruit intake and risk of oral and pharyngeal cancer. Studies were excluded if (i) preparations derived from other fruits were used, (ii) Citrus intake was combined with intake of other fruits; (iii) in vitro or animal models were used. We also excluded reviews, systematic reviews, meta-analyses, letters, personal opinions, conference abstracts and book chapters.Data extraction: Three reviewers independently performed the extraction of data from studies included.Results: Seventeen studies met our inclusion criteria and were included in the final review.Pooled analyses showed that those with the highest Citrus fruit intake compared to the lowest intake had a 50% reduction in risk of oral cavity and pharyngeal cancer (OR 0.50; 95% CI 0.43-0.59). Conclusion:The studies included in this review and meta-analysis showed an inverse association between Citrus fruit intake and oral cancer. 3

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Phytochemical portfolio and anticancer activity of Murraya koenigii and its primary active component, mahanine

Cited by 54 publications

References 70 publications

Anticancer Activity of Mukonal Against Human Laryngeal Cancer Cells Involves Apoptosis, Cell Cycle Arrest, and Inhibition of PI3K/AKT and MEK/ERK Signalling Pathways

Anticancer Activity of Mukonal Against Human Laryngeal Cancer Cells Involves Apoptosis, Cell Cycle Arrest, and Inhibition of PI3K/AKT and MEK/ERK Signalling Pathways

Modulation of cerulein‐induced pancreatic inflammation by hydroalcoholic extract of curry leaf (Murraya koenigii)

Citrus fruits intake and oral cancer risk: A systematic review and meta-analysis

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