Phytochemical profile and antidiabetic effect of the bioactive fraction of Cirsium setidens in streptozotocin-induced type 2 diabetic mice

Shin, Sukjin; Saravanakumar, Kandasamy; Sathiyaseelan, Anbazhagan; Mariadoss, Arokia Vijaya Anand; Park, Seon-Ju; Park, So‐Young; Han, Kiseok; Wang, Myeong-Hyeon

doi:10.1016/j.procbio.2022.02.017

Cited by 7 publications

(3 citation statements)

References 56 publications

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“…Next, the components of the obtained phenolic extracts were separated by liquid-liquid extraction between ethyl acetate and water. Ethyl acetate was selected for the fractionation procedure because previous work showed that the ethyl acetate fraction had a higher concentration of phenolic compounds and inhibited the activity of amylase and glucosidase more effectively compared to the hexane or methanol fraction [ 32 , 33 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…The docking study demonstrated that phenolic compounds identified in V. opulus bark and flower extracts such as chlorogenic acid, neochlorogenic acid, cryptochlorogenic acid, coumaroylquinic acid, caffeic acid, catechin, epicatechin, and rutin had a binding affinity with α-amylase and α-glucosidase [ 32 , 33 , 57 , 58 ]. Moreover, neochlorogenic acid demonstrated strong α-glucosidase catalytic efficiency in terms of binding affinity and hydrogen bonding interaction.…”

Section: Resultsmentioning

confidence: 99%

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In Vitro Inhibitory Effects of Viburnum opulus Bark and Flower Extracts on Digestion of Potato Starch and Carbohydrate Hydrolases Activity

et al. 2022

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One of the effective treatments for diabetes is to reduce and delay the absorption of glucose by inhibition of α-amylase and α-glucosidase in the digestive tract. Currently, there is a great interest in natural inhibitors from various part of plants. In the present study, the phenolic compounds composition of V. opulus bark and flower, and their inhibitory effects on in vitro potato starch digestion as well as on α-amylase and α-glucosidase, have been studied. Bark and flower phenolic extracts reduced the amount of glucose released from potato starch during tree-stage simulated digestion, with IC50 value equal to 87.77 µg/mL and 148.87 µg/mL, respectively. Phenolic bark extract showed 34.9% and 38.4% more potent inhibitory activity against α-amylase and α-glucosidase, respectively, but the activity of plant extracts was lower than that of acarbose. Chlorogenic acid (27.26% of total phenolics) and (+)-catechin (30.48% of total phenolics) were the most prominent phenolics in the flower and bark extracts, respectively. Procyanidins may be responsible for the strongest V. opulus bark inhibitory activity against α-amylase, while (+)-catechin relative to α-glucosidase. This preliminary study provides the basis of further examination of the suitability of V. opulus bark compounds as components of nutraceuticals and functional foods with antidiabetic activity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

In Vitro Inhibitory Effects of Viburnum opulus Bark and Flower Extracts on Digestion of Potato Starch and Carbohydrate Hydrolases Activity

et al. 2022

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“…are sold at local markets in Korea ( Table 1 ). The extracts and compounds obtained from traditional GLVs (1–18) have been shown to possess antioxidant [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ], anticancer [ 18 , 23 , 24 , 25 , 26 ], antiinflammation [ 20 , 25 , 27 , 28 ], anti-melanogenic [ 29 , 30 ], anti-fatigue [ 31 ], anti-obesity [ 32 , 33 ], antidiabetic [ 34 ], and immunostimulatory [ 35 ] activities. GLVs have abundant phytopigments.…”

Section: Introductionmentioning

confidence: 99%

Carotenoid and Tocopherol Profiling in 18 Korean Traditional Green Leafy Vegetables by LC-SIM-MS

Lee

Sivanesan

et al. 2023

Foods

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Fruits and vegetables are a vital source of redox-active phytochemicals in the diet. Traditional green leafy vegetables (GLVs) are a rich source of carotenoids, dietary fiber, minerals, phenols, vitamins, and tocopherols and are commonly consumed in rural areas worldwide. In traditional Korean medicine, many GLVs are used to treat various ailments. However, data on the carotenoid and tocopherol content of many traditional GLVs consumed in the Republic of Korea are insufficient. The current work aims to compare the carotenoid and tocopherol profiles of 18 traditional GLVs by utilizing a single ion monitoring LC-MS approach to identify the potential GLVs for commercial cultivation and healthy diet formulations. Among the traditional GLVs investigated, (all-E)-lutein was the most abundant carotenoid, ranging from 44.4% in Glehnia littoralis to 52.1% in Heracleum moellendorffii. It was followed by (all-E)-violaxanthin and (all-E)-β-carotene. The highest contents of (all-E)-violaxanthin (75.6 µg/g FW), 9-Z-neoxanthin (48.4 µg/g FW), (all-E)-luteoxanthin (10.8 µg/g FW), (all-E)-lutein (174.1 µg/g FW), total xanthophylls (310.5 µg/g FW), (all-E)-β-carotene (69.6 µg/g FW), and total carotenoids (380.1 µg/g FW) were recorded in Pimpinella brachycarpa. Surprisingly, Taraxacum mongolicum also showed the highest contents of (all-E)-violaxanthin, (all-E)-lutein, and total carotenoids, which were statistically non-significant (p > 0.05, Tukey HSD) with P. brachycarpa. The highest concentration of (all-E)-zeaxanthin (14.4 µg/g FW) was recorded in Solidago virga-aurea. Among the studied herbs, 13.9 (H. moellendorffii)–133.6 µg/g FW (Toona sinensis) of α-tocopherol was recorded. Overall, the results suggest that P. brachycarpa and T. mongolicum are rich sources of carotenoids. On the other hand, T. sinensis is a rich source of α-tocopherol. These GLVs can be utilized in the diet to enhance the intake of health-beneficial carotenoids and α-tocopherol.

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Impacts of germination and lactic acid bacteria fermentation on anti-nutrients, bioactive compounds, and selected functional properties of industrial hempseed (Cannabis sativa L.)

Aloo

Park

2023

Food Chemistry

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Phytochemical profile and antidiabetic effect of the bioactive fraction of Cirsium setidens in streptozotocin-induced type 2 diabetic mice

Cited by 7 publications

References 56 publications

In Vitro Inhibitory Effects of Viburnum opulus Bark and Flower Extracts on Digestion of Potato Starch and Carbohydrate Hydrolases Activity

In Vitro Inhibitory Effects of Viburnum opulus Bark and Flower Extracts on Digestion of Potato Starch and Carbohydrate Hydrolases Activity

Carotenoid and Tocopherol Profiling in 18 Korean Traditional Green Leafy Vegetables by LC-SIM-MS

Impacts of germination and lactic acid bacteria fermentation on anti-nutrients, bioactive compounds, and selected functional properties of industrial hempseed (Cannabis sativa L.)

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