Phytochemical Profile and Apoptotic Activity of Onopordum cynarocephalum

Formisano, Carmen; Rigano, Daniela; Russo, Alessandra; Cardile, Venera; Caggia, Silvia; Arnold, Nelly Apostolides; Mari, Angela; Piacente, Sonia; Rosselli, Sergio; Senatore, Felice; Bruno, Maurizio

doi:10.1055/s-0032-1315259

Cited by 18 publications

(15 citation statements)

References 32 publications

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“… Flavonoids, tannins [ 143 ] 0.06 0.11 † Onopordum acanthium L. Asteraceae ISL-98635 Kandyara Herb Leaves, stem Decoction,juice Ulcers Stem decoction is preferably consumed to treat stomach ulcers. Terpenoids [ 144 ] 0.02 0.12 Onosma bracteata Wall. Boraginaceae ISL-95864 Gaozaban Herb Leaves Decoction Stomach disorders Leaves infusion is consumed after regular intervals until get relief from stomachache.…”

Section: Resultsmentioning

confidence: 99%

Traditional knowledge on herbal drinks among indigenous communities in Azad Jammu and Kashmir, Pakistan

Rashid

Gbèdomon

Ahmad

et al. 2018

J Ethnobiology Ethnomedicine

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BackgroundTraditional knowledge about the use of medicinal plants for herbal drinks (HDs) is not well documented in the Azad Kashmir region despite their widespread use. This study highlights the taxonomic diversity and traditional knowledge on medicinal plants used for HDs while examining the diversity of diseases treated with HDs in the study area.MethodsIndividual discussions were conducted with 255 informants (84 women and 171 men). Data gathered included (i) informant age and gender, (ii) HD species and respective plant parts used, (iii) health disorders treated, and (iv) mode of preparation and utilizations. Quantitative ethnobotanical indices including relative frequency of citation (RFC), informant consensus factor (ICF), and use value (UV) were used for data analyses.ResultsAltogether, 73 medicinal plants belonging to 40 families and 66 genera were reported to be used in HD preparations, with Asteraceae being the richest family. The average number of HD species cited was 9.09 ± 0.17 per informant and did not vary either by age or gender. In addition, men and women, and adults and the young used the same pool of species (dissimilarity nearly zero). The most used plant parts were leaves (20.00%), roots (17.25%), and fruits (16.47%). Based on UV, the top five most used species were Valeriana jatamansi, Isodon rugosus, Onopordum acanthium, Acacia nilotica, and Viola canescens; and the UV was similar among gender and age categories too. The most utilized herbal preparation forms included decoctions, infusions, and tea. One hundred and eleven diseases grouped into 13 ailment categories were reported to be cured using HDs. The main category of disease treated with HDs was gastrointestinal (GIT) disorders (RFC = 17.43%). Relatively few species were used by a large proportion of informants for each category of ailment (ICF ≥ 0.60). Only one species was used for “glandular disorders” and “eye diseases” (ICF = 1).A novelty of about 22% (16 species) was recorded for HD species in the present work.ConclusionThe diversity of medicinal plant species used as HDs and the associated traditional knowledge are of considerable value to the indigenous communities of the Azad Kashmir region. Therefore, there is a need for conservation and preservation of medicinal HD species as well as the wealth of indigenous knowledge. The conservation effort should be high for species in the ailments categories glandular disorders and eye diseases. The therapeutic uses of HDs have provided basic data for further research focused on phytochemical and pharmacological studies and conservation of the most important species.

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Section: Resultsmentioning

confidence: 99%

Traditional knowledge on herbal drinks among indigenous communities in Azad Jammu and Kashmir, Pakistan

Rashid

Gbèdomon

Ahmad

et al. 2018

J Ethnobiology Ethnomedicine

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“…Analysis of essential oil from the stem and leaf of A. monosperma has revealed 130 components [ 17 ]. An eudesmane sesquiterpene present in A. monosperma [ 18 ] has been associated with apoptotic cell death in the human melanoma A375 cell line [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluating Medicinal Plants for Anticancer Activity

Solowey¹,

Lichtenstein²,

Sallon

et al. 2014

The Scientific World Journal

235

135

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Plants have been used for medical purposes since the beginning of human history and are the basis of modern medicine. Most chemotherapeutic drugs for cancer treatment are molecules identified and isolated from plants or their synthetic derivatives. Our hypothesis was that whole plant extracts selected according to ethnobotanical sources of historical use might contain multiple molecules with antitumor activities that could be very effective in killing human cancer cells. This study examined the effects of three whole plant extracts (ethanol extraction) on human tumor cells. The extracts were from Urtica membranacea (Urticaceae), Artemesia monosperma (Asteraceae), and Origanum dayi post (Labiatae). All three plant extracts exhibited dose- and time-dependent killing capabilities in various human derived tumor cell lines and primary cultures established from patients' biopsies. The killing activity was specific toward tumor cells, as the plant extracts had no effect on primary cultures of healthy human cells. Cell death caused by the whole plant extracts is via apoptosis. Plant extract 5 (Urtica membranacea) showed particularly strong anticancer capabilities since it inhibited actual tumor progression in a breast adenocarcinoma mouse model. Our results suggest that whole plant extracts are promising anticancer reagents.

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“…Several researchers revealed the identification of 130 constituents from the stem leaf of A. monosperma essential oil has an apoptotic cell in the human melanoma A375 cell line in-vitro anticancer effect on colorectal breast cancer cell lines by polyacetylene dehydrofal carindiol. Capillin (1-phenyl-2,4-pentadiyne), one more polyacetylene present in A. monosperma, was validated to persuade apoptosis in various human cancer cell lines like pancreatic MIA PaCa-2, colon HT29, lung carcinoma A549 cells, epidermoid carcinoma of the larynx HEp-2 (Stavri et al 2004;Formisano et al 2012;Khan et al 2012;Solowey et al 2014). Based on the above study artemisinin and its spinoffs have also been introduced as possible cancer treatments that affect multiple pathways.…”

Section: Antiasthmatic Activitymentioning

confidence: 99%