Phytochemical profile and pro-healthy properties of
            <i>Terminalia chebula</i>
            : A comprehensive review

Sultan, Muhammad Tauseef; Anwar, Muhammad İrfan; Imran, Muhammad Ali; Khalil, Ijaz; Saeed, Farhan; Neelum, Shahzadi; Alsagaby, Suliman A.; Abdulmonem, Waleed Al; Abdelgawad, Mohamed A.; Hussain, Muzzamal; El‐Ghorab, Ahmed H.; Umar, Maryam; Jbawi, Entessar Al

doi:10.1080/10942912.2023.2166951

Cited by 14 publications

(4 citation statements)

References 110 publications

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“…Haritaki is used most commonly for treatment purposes. It is known as Harad in Hindi and Myrobalan in English (Sultan et al, 2023).…”

Section: E Officinalis Gaertn As An Immunomodulatormentioning

confidence: 99%

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Ayurvedic Medicinal Plants as Immunity Stimulant: A Comprehensive Guide

Majeed,

Ali,

Aslam

et al. 2023

Complementary and Alternative Medicine: One Health Perspective

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The ancient Indian traditional medical system known as Ayurveda has long recognized the value of natural treatments, such as medicinal plants, in enhancing immune system function and general well-being. The main Ayurvedic medicinal herbs recognized for their ability to stimulate immunity include Ocimum sanctum (Tulsi), Emblica officinalis (Amla), Azadirachta indica (Neem), and Withania somnifera (Ashwagandha), show a range of immunomodulatory benefits, such as increased immune cell activity, anti-inflammatory responses, and antioxidant qualities. Gaining knowledge about and utilizing the benefits of these Ayurvedic medicinal herbs can greatly boost immunity and enhance general well-being. In Ayurveda, ashwagandha is a typical adaptogenic plant used to decrease stress and strengthen immunity. It is thought to strengthen the body's resistance to a range of illnesses and infections. In Ayurveda, tulsi is revered as a sacred herb. It can help boost immunity and fight infections because of its antibacterial and immunomodulatory qualities. Neem possesses antiviral, antibacterial, and antifungal properties. It is useful in treating and preventing a variety of infections since it strengthens the immune system and purifies the blood. This chapter elaborates on certain medicinal plants known for their immune-stimulating properties.

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“…Haritaki is used most commonly for treatment purposes. It is known as Harad in Hindi and Myrobalan in English (Sultan et al, 2023).…”

Section: E Officinalis Gaertn As An Immunomodulatormentioning

confidence: 99%

“…These compounds have different but very strong therapeutic potentials. It contains many phenolic compounds, such as anthraquinone and glycosides (Sultan et al, 2023). Likewise, it also possesses hydrolyzable and non-hydrolysable tannins.…”

Section: Chemical Constituents Of T Chebulamentioning

confidence: 99%

Ayurvedic Medicinal Plants as Immunity Stimulant: A Comprehensive Guide

Majeed,

Ali,

Aslam

et al. 2023

Complementary and Alternative Medicine: One Health Perspective

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“…Tumor cells that remain in the lymph nodes can proliferate and eventually breach the node’s capsule. Lymph nodes can also serve as a source from which tumor cells enter the bloodstream, spreading to distant organ sites such as the bones, liver, brain, and lungs ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…tumor cells enter the bloodstream, spreading to distant organ sites such as the bones, liver, brain, and lungs (9).…”

mentioning

confidence: 99%

Cell cycle arrest and apoptotic studies of Terminalia chebula against MCF-7 breast cancer cell line: an in vitro and in silico approach

Reddy,

Pradeep,

S. M.

et al. 2023

Front. Oncol.

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Breast cancer is a leading cause of mortality in women, and alternative therapies with fewer side effects are actively being explored. Breast cancer is a significant global health concern, and conventional treatments like radiotherapy and chemotherapy often have side effects. Medicinal plant extracts offer a promising avenue for the development of effective and safe anticancer therapies. Terminalia chebula, a plant known for its medicinal properties, was selected for investigation in this study. We aimed to assess the antiproliferative effects of TCF extract on breast cancer cells and explore the potential role of saccharopine, a phytochemical found in TCF, as an anticancer agent. MCF7 breast cancer cell lines were exposed to TCF extract, and cell viability and apoptosis assays were performed to evaluate the antiproliferative and apoptogenic effects. Molecular docking studies were conducted to assess the binding affinity of saccharopine with EGFRs. Molecular dynamics simulations and binding energy calculations were employed to analyze the stability of the EGFR-saccharopine complex. The TCF extract exhibited significant antiproliferative effects on MCF7 breast cancer cells and induced apoptosis in a dose-dependent manner. Molecular docking analysis revealed that saccharopine demonstrated a higher binding affinity with EGFR compared to the reference compound (17b-estradiol). The subsequent MDS simulations indicated stable binding patterns and conformation of the EGFR-saccharopine complex, suggesting a potential role in inhibiting EGFR-mediated signaling pathways. The investigation of Terminalia chebula fruit extract and its phytochemical saccharopine has revealed promising antiproliferative effects and a strong binding affinity with EGFR. These findings provide a foundation for future research aimed at isolating saccharopine and conducting in vivo studies to evaluate its potential as a targeted therapy for breast cancer. The development of novel anticancer agents from plant sources holds great promise in advancing the field of oncology and improving treatment outcomes for breast cancer patients.

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