Phytochemical Profiling and Biological Activity of <i>Achillea sintenisii</i> Hub.‐Mor

Eruygur, Nuraniye; Buyukyildirim, Tugsen; Tetik Rama, Seyma; Ayaz, Fatma; Tekin, Mehmet; Tuzcu, Mehmet; Akcakavak, Gokhan; Abdullah Yilmaz, Mustafa

doi:10.1002/cbdv.202201258

Cited by 3 publications

(1 citation statement)

References 59 publications

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“…It mitigates its negative effects by damaging vital components like DNA, proteins, and lipids. [36] Antioxidants are therefore a useful tool in reducing molecular damage caused by oxidative stress, which is essential for maintaining human health. [37] Due to their capacity to neutralize free radicals by providing an electron or hydrogen atom to a number of reactive oxygen, nitrogen, or chlorine species, polyphenols have been described as potent antioxidants.…”

Section: Antioxidant Propertiesmentioning

confidence: 99%

Detailed Phytochemical Evaluation of a Locally Endemic Species (Campanula baskilensis) by LC‐MS/MS and Its In‐Depth Antioxidant and Enzyme Inhibitory Activities

Yilmaz,

Cakir,

Izol

et al. 2023

Chemistry & Biodiversity

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The importance of bioactive plant species in the scientific world is increasing day by day. The relationship between health and traditional‐modern life, promotes the creation of new value‐added natural products. This is the first research to conduct a bioactivity and chemical composition analysis of Campanula baskilensis species, which belongs to the medicinally important genus Campanula L (Campanulaceae). The aim of the current study is to quantitatively investigate the phytochemical contents of aerial and root parts of different C. baskilensis extracts (ethanol, methanol, and water) by LC‐MS/MS and to evaluate their total phenolic and flavonoid contents, antioxidant and enzyme inhibitory activities. Remarkably, LC‐MS/MS results revealed that, high amounts of quinic acid (53.6 mg/g aerial‐MeOH extract), fumaric acid (6.3 mg/g aerial‐H2O extract, 2.5 mg/g root‐ H2O extract), protocatechuic acid (11.4 mg/g aerial‐H2O extract), vanilic acid (1.4 mg/g aerial‐EtOH extract), quercetin‐3‐O‐rutinoside (rutin) (2.3 mg/g aerial‐EtOH extract), hesperetin 7‐rutinoside (hesperidin) (2.0 mg/g aerial‐EtOH extract), kaempferol‐3‐O‐rutinoside (nicotiflorin) (5.5 mg/g aerial‐EtOH extract) were detected in the extracts of the species. Considering the bioactivity tests performed on C. baskilensis extracts, aerial‐H2O extract showed significant activity in all antioxidant assays. However, ethanol extracts of root and aerial parts exhibited the highest activities in all enzyme inhibitory tests.

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Section: Antioxidant Propertiesmentioning

confidence: 99%

Detailed Phytochemical Evaluation of a Locally Endemic Species (Campanula baskilensis) by LC‐MS/MS and Its In‐Depth Antioxidant and Enzyme Inhibitory Activities

Yilmaz,

Cakir,

Izol

et al. 2023

Chemistry & Biodiversity

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45S5 Bioactive Glass‐Ointment Positively Effects on Wound Healing in Rats by Regulating TNFα, Il‐10, VEGF, and TGFβ

Kırgız,

Altuğ,

Özkan

et al. 2024

Clinical Laboratory Analysis

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AimThis study aimed to investigate the effects of 45S5 bioactive glass‐ointment (BG) on cutaneous wound healing in rats at the molecular, biochemical, and histopathological levels.Materials and MethodsThirty‐two rats were divided into four groups (n = 8): Control, Sham, BG, and DEX (Dexpanthenol). While no wound treatment was applied to the CONTROL, a wound model was created in the Sham, and no treatment was applied. A wound model was created for other groups, and BG and DEX were applied locally for 21 days. During the 21‐day experiment period, feed and water consumption and weight changes were observed. Wound areas were calculated on days 0, 3, 7, 4, and 21. Following treatment, the rats were euthanized and tissues from the wound area and blood samples were collected. While the expression levels of tumor necrosis factor‐alpha (TNFα), Interleukin 6 (IL6), Interleukin 10 (IL10), transforming growth factor‐beta (TGFβ), and vascular endothelial growth factor (VEGF) genes were determined by qPCR, the levels of TNFα, IL6, and IL10 proteins were measured by ELISA.ResultsIt was observed that the BG group showed anti‐inflammatory activity by suppressing TNFα levels and stimulating IL‐10. In addition, it was determined that BG increased fibroblast activity and vascularization.ConclusionCurrent findings showed that topical application of BG has anti‐inflammatory effects, while also accelerating healing by increasing vascularity and making positive contributions to tissue healing.

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Evaluation of potential anti-aging effects of Achillea phrygia Boiss. & Balansa (Asteraceae)

Boran Gülen,

Saraç,

Uğur

2024

International Journal of Secondary Metabolite

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This study aims to determine the anti-aging effects of Achillea phrygia, an endemic plant, by evaluating its sun protection factor (SPF) level, antioxidant activity, total phenolic content, extracellular matrix-degrading enzymes (ECM) inhibition, genotoxic/anti-genotoxic, and cytotoxic activities. The SPF level was assessed using an in vitro quantitative method, while antioxidant capacity was determined through DPPH, β-carotene, and hydroxyl-radical (H2O2) scavenging assays. The total phenolic content was quantitatively conducted using the Folin Ciocalteu reagent. The inhibition of ECM-degrading enzymes was determined using matrix metalloproteinase-1 (MMP-1), hyaluronidase, and elastase enzymes. Genotoxic/anti-genotoxic properties were assessed using the AMES Salmonella/microsome assay, and cytotoxicity effects were assessed through the MTT assay. The results indicated that A. phrygia showed moderate SPF activity (SPF = 4.013) and exhibited IC50 values of 0.183 ± 0.03, 0.079 ± 0.51, and 1.18 ± 0.35 mg/mL for DPPH, β-carotene, and hydroxyl-radicals, respectively. The total phenolic content was measured to be 23.56 ± 1.42 mg GAE/g dry extract. Furthermore, the extract demonstrated inhibition of MMP-1 (47.98%) and elastase (39.2%) activities. Importantly, it did not induce DNA damage and showed antigenotoxic activity ranging from 10% to 65.6%. The cytotoxicity assay revealed an IC50 value of 42.41±4.05 µg/mL. These findings suggest that A. phrygia could be utilized as a cosmetic ingredient in skincare products due to its ability to protect against UV radiation, exhibit antioxidant properties, prevent extracellular matrix degradation, and inhibit DNA damage.

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Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor

Cited by 3 publications

References 59 publications

Detailed Phytochemical Evaluation of a Locally Endemic Species (Campanula baskilensis) by LC‐MS/MS and Its In‐Depth Antioxidant and Enzyme Inhibitory Activities

Detailed Phytochemical Evaluation of a Locally Endemic Species (Campanula baskilensis) by LC‐MS/MS and Its In‐Depth Antioxidant and Enzyme Inhibitory Activities

45S5 Bioactive Glass‐Ointment Positively Effects on Wound Healing in Rats by Regulating TNFα, Il‐10, VEGF, and TGFβ

Evaluation of potential anti-aging effects of Achillea phrygia Boiss. & Balansa (Asteraceae)

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