Phytochemical profiling, antioxidant activities and in vitro/in silico enzyme inhibitory potentials of apricot cultivars grown in Iğdır/Turkey

Karaçelik, Ayça Aktaş

doi:10.1016/j.sajb.2023.03.038

Cited by 6 publications

(2 citation statements)

References 72 publications

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“…'Boriss' fruit contained the lowest (Table 5 and Supplementary Figure S1). The dominance of RT in four apricot cultivars and one wild genotype grown in the I gdır region in Turkey was reported by Karaçelik [79], indicating the range from 24.7 to 696.5 µg g −1 DW. This observation is reinforced by data provided by Cirillo et al [31], emphasizing the relative abundance of RT over other phenolic compounds in 12 apricot genotypes of Italian origin.…”

Section: The Content Of Individual Phenolic Compounds In Apricot Frui...mentioning

confidence: 67%

Biochemical Profile and Antioxidant Activity of Dried Fruit Produced from Apricot Cultivars Grown in Latvia

Juhnevica-Radenkova,

Krasnova,

Seglina

et al. 2024

Horticulturae

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The present study focused on evaluating the biochemical profiles of four apricot cultivars (cv.) (Prunus armeniaca L.) grown in Latvia and demonstrating their processing to obtain the food product, dried candied fruit (DCF). The fingerprinting of apricot fruit approached by LC-MS and ultraviolet–visible spectroscopy revealed the abundance of bioactives responsible for the antioxidant activity. The outstanding composition of group compounds, i.e., phenolics, flavonoids, and vitamin C, was observed in the cv. ‘Dimaija’, followed by cv. ‘Gundega’ and cv. ‘Velta’. The lowest values were found in the cv. ‘Boriss’ and fruit from a market of Greek origin. However, the latter two contained the highest carotenoid levels due to a more pronounced maturity. Amongst the 13 individual phenolics detected, rutin, chlorogenic and neochlorogenic acids, catechin, and epicatechin prevailed. The concentrations observed were the highest in cv. ‘Dimaija’, followed by cv. ‘Velta’ and cv. ‘Gundega’. Osmotic dehydration and convective drying of apricot fruit variedly influenced the content of bioactives in DCF products. The most substantial decrease due to thermal lability was observed in the vitamin C content in DCF, accounting for a 95.3% loss for all cultivars. The content of total phenolics, flavonoids, and carotenoids in DCF, on average, was 62.7%, 49.6%, and 87.6% lower than that observed in the raw fruit, respectively. On average, the content of individual phenolics in DCF, such as rutin and chlorogenic acid, decreased by 63.8% and 20.8%, respectively. The decline in the content of bioactives was conditioned by the physical migration of the cell components to the hypertonic solution. However, the increase in the content of cell wall-bound phytochemicals, such as catechin and epicatechin, after osmotic dehydration and convective drying, was observed in DCF, corresponding to a 59.5% and 255.64% increase compared with the raw fruit, respectively. Panelists generally responded positively to the developed DCF; however, greater preference was given to products with a lower phenolic content, such as cv. ‘Boriss’ and those produced from the market fruit. It is believed that the high flavan-3-ols content, along with chlorogenic acid, contributed to the bitter taste of DCF. Overall, apricot fruits represent the abundance of bioactives retained in DCF after osmotic dehydration and convective drying. The findings observed in the current study allow to consider DCF as a functional food; however, given the high sugar content, their consumption should be in moderation.

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Section: The Content Of Individual Phenolic Compounds In Apricot Frui...mentioning

confidence: 67%

Biochemical Profile and Antioxidant Activity of Dried Fruit Produced from Apricot Cultivars Grown in Latvia

Juhnevica-Radenkova,

Krasnova,

Seglina

et al. 2024

Horticulturae

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“…In a study, the methanol and aqueous extracts of five apricot cultivars were investigated for their effects against the urease enzyme involved in treating stomach conditions such as carcinomas and ulcers. In the study, it was found that both methanol and aqueous extracts exhibited inhibitory effects on the urease enzyme, with IC50 values ranging from 20.763 to 195.437 mg/mL [34].…”

Section: Acetylcholinesterase and Urease Enzyme Inhibitionmentioning

confidence: 99%

Molecular docking study on acetylcholinesterase and urease enzyme inhibition effects of Amygdalin

CAN,

KARA,

GÜLER

et al. 2023

Turkish Journal of Analytical Chemistry

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This study investigated that the acetylcholinesterase, urease enzyme inhibition and these enzymes molecular docking as well as antioxidant activity of commercially available amygdalin. While Amygdalin displayed effect anti-urease activity compared to acetohydroxamic acid but, anti-acetylcholine esterase activity a little ineffective compared to donepezil. The molecular docking was performed in order to check binding interactions between the amygdalin and the enzymes. DPPH and FRAP assays were preferred to determine the antioxidant activity. The antioxidant activity (3.39±0.33 µmol Fe2SO47H2O /g, SC50 18.74±0.72 mg/mL using the FRAP and DPPH assays, respectively. Amygdalin's in vitro and in vivo studies are needed for demonstrated that is a therapeutic agent for the treatment of various diseases.

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Phytochemical and Biological Evaluation of Cyanus celikhanensis Extract: An in Silico and in Vitro Approach

Baş Topcu,

Sağ,

Genç

et al. 2025

Chemistry & Biodiversity

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Herbal products are valuable biological resources of bioactive compounds expressed as secondary metabolites. This study aimed to explore the potential biological properties and phenolic content of Cyanus celikhanensis, which has no data on pharmacological properties. A quantitative phytochemical analysis of C. celikhanensis was performed using a LC_MS/MS System. In vitro pharmacological tests, which included antioxidant, antimicrobial, antiproliferative, and ten medicinal enzyme inhibition, were accompanied by in silico studies. The extract exhibited promising inhibitory effect against HMG‐CoA reductase (IC50: 0.724 µg mLˉˡ), α‐glucosidase (IC50: 68 µg mLˉˡ), and α‐amylase (IC50: 114 µg mLˉˡ) enzymes. The extract presented a cytotoxic effect (130.4 µg mLˉˡ), anti‐bacterial potency against E. faecalis (591.2 ± 2.7 µg mLˉˡ), and ABTS scavenging activity (12.32 µg mLˉˡ) closer to that of BHT (8.12±0.096 µg mLˉˡ). The quantitative phytochemical analysis revealed that the major compounds were keracyanin chloride (72.56 µg mLˉˡ) and quinoic acid (12.54 µg mLˉˡ). The molecular insertion studies showed that the major compound has low binding energy, and the biological capacity of the plant extract might be attributable to its leading compounds, especially keracyanin. According to the first comprehensive in vitro and in silico analysis, the study data show that C. celikhanensis has potential biological activities.

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Phytochemical profiling, antioxidant activities and in vitro/in silico enzyme inhibitory potentials of apricot cultivars grown in Iğdır/Turkey

Cited by 6 publications

References 72 publications

Biochemical Profile and Antioxidant Activity of Dried Fruit Produced from Apricot Cultivars Grown in Latvia

Biochemical Profile and Antioxidant Activity of Dried Fruit Produced from Apricot Cultivars Grown in Latvia

Molecular docking study on acetylcholinesterase and urease enzyme inhibition effects of Amygdalin

Phytochemical and Biological Evaluation of Cyanus celikhanensis Extract: An in Silico and in Vitro Approach

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