Phytochemical profiling, in vitro and in vivo xanthine oxidase inhibition and antihyperuricemic activity of Christia vespertilionis leaf

Endrini, Susi; Bakar, Fazleen Izzany Abu; Bakar, Mohd Fadzelly Abu; Abdullah, Nik Rosli; Marsiati, Himmi

doi:10.1016/j.bcab.2023.102645

Cited by 8 publications

(2 citation statements)

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“…Gout is one of the relatively common inflammatory diseases of the joints caused by the deposition of uric acid crystals in the tissues, in which uric acid is produced by xanthine oxidase (XO) acting on the purine bases hypoxanthine and xanthin . In developed countries, the prevalence of gout is 3–6% in males and 1–2% in females, with a strong impact on individual health and healthcare systems .…”

Section: Introductionmentioning

confidence: 99%

“…Gout is one of the relatively common inflammatory diseases of the joints caused by the deposition of uric acid crystals in the tissues, 8 in which uric acid is produced by xanthine oxidase (XO) acting on the purine bases hypoxanthine and xanthin. 9 In developed countries, the prevalence of gout is 3–6% in males and 1–2% in females, with a strong impact on individual health and healthcare systems. 10 Studies in recent years have shown that gout is an independent risk factor for chronic kidney disease, hypertension, cardiovascular and cerebrovascular diseases, diabetes, and an independent predictor of premature death.…”

Section: Introductionmentioning

confidence: 99%

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Lignan and Phthalide Derivatives from the Rhizome of Ligusticum chuanxiong (Rhizoma chuanxiong) and Evaluation of Their anti-Xanthine Oxidase Activities

Yang,

Tang

et al. 2023

ACS Omega

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The previous research results showed that the extracts of ethyl acetate of the rhizome of Ligusticum chuanxiong (Rhizoma chuanxiong) possessed significant antigout effects in model mice. To explore the active ingredients responsible for the effects, phytochemical studies were performed, which led to the isolation of three rare 8′, 9-linked neolignans, ligusticumins A–C (1–3), together with two novel phthalide-phenylpropanoid heterodimers, ligusticumalides A–B (4 and 5). It is noteworthy that 4 possesses an unprecedented 7-styryl phthalide skeleton. The structures and absolute configurations of 1–5 were elucidated by one-dimensional (1D) and two-dimensional (2D) NMR spectroscopy and electron-capture detector (ECD) spectroscopic methods. The bioassay results showed that compounds 1, 2, 3, and 5 presented moderate inhibitory activities against xanthine oxidase (XO) and 4 possessed a significant XO inhibitory effect with an IC50 value of 93.88 μM. This is the first time to investigate the anti-XO active ingredients of R. chuanxiong, which provides valuable information for searching for new antigout agents from natural products.

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Section: Introductionmentioning

confidence: 99%