Phytochemical profiling, in vitro and in vivo anti-inflammatory, analgesic and antipyretic potential of Sesuvium sesuvioides (Fenzl) Verdc. (Aizoaceae)

Evaluation of Biological Activity of Natural Compounds: Current Trends and Methods

“…The correlation mentioned above can be exploited to evaluate new compounds. As shown in Figure 3 , these experiments are performed on animal brain membranes, which have a high density of the receptors of interest; in the assay, different concentrations of the test compound are evaluated against a fixed concentration of specific radioligands [ 128 , 129 , 130 ]. These assays help identify compounds that recognize the same binding site as known radiolabeled ligands.…”

“…ceptors of interest; in the assay, different concentrations of the test compound are evaluated against a fixed concentration of specific radioligands [128][129][130]. These assays help identify compounds that recognize the same binding site as known radiolabeled ligands.…”

Characterization of Sesuvium sesuvioides Using High-Performance Liquid Chromatography and Validation of Its In Vivo Anti-hyperthyroidism Effect via Suppressing Oxidative Stress and Inflammatory Markers

“…HPLC analysis of S. sesuvioides methanol extract revealed the presence of gallic acid (0.73 ppm/mg), benzoic acid (11.22 ppm/mg), p-coumaric acid (3.12 ppm/mg), ferulic acid (5.47 ppm/mg), cinnamic acid (3.54 ppm/mg), and sinapic acid (3.17 ppm/ mg) as shown in Table 1. Besides, our previous studies on S. sesuvioides methanol extract using GC−MS showed the existence of vanillin, umbelliferone, 2-methoxy-4-vinylphenol, phytol, palmitoleic acid, and methyl palmitate with potent antiinflammatory effects 14 (Figure 1).…”

“…Besides, our previous studies on S. sesuvioides methanol extract using GC–MS showed the existence of vanillin, umbelliferone, 2-methoxy-4-vinylphenol, phytol, palmitoleic acid, and methyl palmitate with potent anti-inflammatory effects (Figure ).…”

“…sesuvioides revealed potent antipyretic, analgesic, and anti-inflammatory activity. Gas chromatography–mass spectrometry (GC–MS) analysis showed the richness of the extract with multiple constituents such as vanillin, umbelliferone, 2-methoxy-4-vinylphenol, phytol, palmitoleic acid, and methyl palmitate …”