Phytochemical Prospection and Biological Activity of Astrodaucus orientalis (L.) Drude Growing Wild in Iran

Razavi, Seyed Mehdi; Imanzadeh, G.; Nejad-Ebra, S.; Majrouhi, A A; Zahri, Saber; Ghasemian, Abdolmajid

doi:10.5567/pharmacologia.2011.299.303

Cited by 11 publications

(6 citation statements)

References 4 publications

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“…50 α-Pinene, α-thujene, α-copaene, fenchyl-acetate, anisole, myrecene, and sabinene are the most important compounds in this plant. 51 , 52 Inhibition of cell cycle and also induction of apoptosis is the main mechanism of anticancer effects of the plant. 50…”

Section: Resultsmentioning

confidence: 99%

Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study

Kooti

Servatyari

Behzadifar

et al. 2017

J Evid Based Complementary Altern Med

213

149

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Cancer is the second cause of death after cardiovascular diseases. With due attention to rapid progress in the phytochemical study of plants, they are becoming popular because of their anticancer effects. The aim of this study was to investigate the effective medicinal plants in the treatment of cancer and study their mechanism of action. In order to gather information the keywords “traditional medicine,” “plant compounds,” “medicinal plant,” “medicinal herb,” “toxicity,” “anticancer effect,” “cell line,” and “treatment” were searched in international databases such as ScienceDirect, PubMed, and Scopus and national databases such as Magiran, Sid, and Iranmedex, and a total of 228 articles were collected. In this phase, 49 nonrelevant articles were excluded. Enhancement P53 protein expression, reducing the expression of proteins P27, P21, NFκB expression and induction of apoptosis, inhibition of the PI3K/Akt pathway, and reduction of the level of acid phosphatase and lipid peroxidation are the most effective mechanisms of herbal plants that can inhibit cell cycle and proliferation. Common treatments such as radiotherapy and chemotherapy can cause some complications. According to results of this study, herbal extracts have antioxidant compounds that can induce apoptosis and inhibit cell proliferation by the investigated mechanisms.

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Section: Resultsmentioning

confidence: 99%

Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study

Kooti

Servatyari

Behzadifar

et al. 2017

J Evid Based Complementary Altern Med

213

149

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“…[35] Sabinene (18.01 %), α-pinene (10.50 %) and α-thujene were found the major components of flower essenntial oil. [36] αpinene (32.7 %), α-fenchyl acetate (14.5 %), β-pinene (8.5 %) and bornyl acetate (7.9 %) were seen as major components of aerial part essential oil of A. orientalis. [37] These findings provide valuable insights into the chemical composition of essential oils from various parts of A. orientalis, shedding light on the potential bioactive compounds present in these oils.…”

Section: Gc-fid and Gc/ms Methods For Essential Oil Isolationmentioning

confidence: 99%

Exploring Astrodaucus orientalis (L.) Drude: Phytochemical Analysis and its Biological Potential Against Alzheimer's and Diabetes

Yuca,

Aydin,

Karakaya

et al. 2024

Chemistry & Biodiversity

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In current study antioxidant, antidiabetic, antimicrobial, anticholinesterase, and human carbonic anhydrase I, and II (hCA I and II) isoenzymes inhibition activities of Astrodaucus orientalis different parts were investigated. Achetylcholinesterse (AChE) and butyrylcholinesterse (BChE) inhibitory activities of octyl acetate were determined via molecular docking. Quantitative assessment of specific secondary metabolites was conducted using LC‐MS/MS. An examination of chemical composition of essential oils was carried out by GC‐MS/MS. A thorough exploration of plant's anatomical characteristics was undertaken. The highest phenolics level and DPPH antioxidant capacity were seen in root and fruit. Fruit essential oil demonstrated the highest AChE inhibition (44.13±3.61%), while root dichloromethane sub‐extract had the best inhibition towards BChE (86.13±2.58%). Cytosolic hCA I, and II isoenzymes were influentially inhibited by root oil with 1.974 and 2.207 µM IC50 values, respectively. The most effective extracts were found to be root all extract/sub‐extracts (except water) against C. tropicalis and C. krusei strains with MIC value 160> µg/mL. Sabinene (29.4%), α‐pinene (20.2%); octyl acetate (54.3%); myrcene (28.0%); octyl octanoate (71.3%) were found principal components of aerial parts, roots, flowers, and fruits, respectively. Flower essential oil, fruit dicloromethane and ethyl acetate exhibited potent α‐glucosidase inhibitory activity with 900, 40, and 937 µg/mL IC50 values, respectively.

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“…The essential oil from different parts of A. orientalis contains fenchyl acetate as a major compound [4-6], while the major constituent in the essential oil of A. persicus was α-thujene [7]. The hexane extract from aerial parts of A. orientalis was found to be rich in phenolic derivatives [8], and antimalarial and cytotoxic activities of A. persicus extracts were reported [9]. The excellent match of ECD spectra (Figure 3) for theoretical and experimental stereoisomer led to establishing an absolute configuration of astrodaucanolide C as 1S,3R,6S,7R,8S,10R,11S.…”

Section: Introductionmentioning

confidence: 99%

“…The essential oil from different parts of A. orientalis contains fenchyl acetate as a major compound 4 , 5 , 6 , while the major constituent in the essential oil of A. persicus was α -thujene 7 . The hexane extract from aerial parts of A. orientalis was found to be rich in phenolic derivatives 8 , and antimalarial and cytotoxic activities of A. persicus extracts were reported 9 .…”

Section: Introductionmentioning

confidence: 99%

“…The essential oil from different parts of A. orientalis contains fenchyl acetate as a major compound [4-6], while the major constituent in the essential oil of A. persicus was α-thujene [7]. The hexane extract from aerial parts of A. orientalis was found to be rich in phenolic derivatives [8], and antimalarial and cytotoxic activities of A. persicus extracts were reported [9].Continuing to discover new bioactive natural products from plants of the Iranian flora [10][11][12], we here report the isolation and structure elucidation of new sesquiterpene lactones and known phenylpropanoid derivatives from petals of A. orientalis, and on their assessment for antiplasmodial activity.…”

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confidence: 99%

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Sesquiterpene Lactones with Astrodaucane Skeleton from Astrodaucus orientalis

et al. 2022

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Four sesquiterpene lactones, astrodaucanolide A-D (1-4) with unique structures, toghether with two known phenylpropanoid esters (5 and 6) were isolated from a flower extract of Astrodaucus orientalis. The structures were established by 1D and 2D NMR spectroscopy and high-resolution mass spectrometry (HRESIMS), and the absolute configuration of 1-4 was determined by electronic circular dichroism (ECD). Compounds 1-4 novel architecture represents a new class of sesquiterpenes with new skeleton. A putative biosynthetic pathway for their scaffold is proposed with a germacryl cation as the precursor. The suggested biosynthesis pathway is similar to that of eudesmane sesquiterpenes with a different direction of protonation which then leads to the new skeleton, named astrodaucane by the 1,2-methyl migration.

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Phytochemical Prospection and Biological Activity of Astrodaucus orientalis (L.) Drude Growing Wild in Iran

Cited by 11 publications

References 4 publications

Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study

Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study

Exploring Astrodaucus orientalis (L.) Drude: Phytochemical Analysis and its Biological Potential Against Alzheimer's and Diabetes

Sesquiterpene Lactones with Astrodaucane Skeleton from Astrodaucus orientalis

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