Phytochemical Screening and Anti-Inflammatory Effect of Marrubium vulgare L. Methanol Extract on Carrageenan-Induced Paw Inflammation in Rats

The bioactive ingredients and therapeutic effects of Marrubium vulgare - A review

“…The Antioxidant activity of the methanolic extract of the aerial parts of Marrubium vulgare was evaluated using DPPH radical scavenging assay and nitric oxide radical inhibition assay. The extract RC50 values for DPPH and nitric oxide antioxidant activity of the methanolic extract were 177 μg/ml and 370.5 μg/ml respectively [39].…”

“…The total phenolic contents of Marrubium vulgare leaves were 40.7-160 mg gallic acid equivalents/g and total flavonoids concentrations were 27.4-66.3 mg catechin equivalents/g [38]. While, the total phenolic and flavonoids in the aerial parts of Marrubium vulgare were 625 mg gallic acid equivalent, and 1.62 g quercetin equivalent per 100 g of dried plant aerial parts respectively [39].…”

“…The anti-inflammatory effects of the methanolic extract of the aerial parts of Marrubium vulgare was evaluated in carrageenan-induced paw edema in rats. Marrubium vulgare methanolic extract (2.5, 5, 10 mg/kg) alleviated paw inflammation as determined by reduction of paw thickness (P<0.001) as well as, myeloperoxidase activity (P<0.001), which was associated with a marked decrease in tissue edema [39].…”

Phytochemical profile and therapeutic potential of white horehound (Marrubium vulgare) – a review of the current state of knowledge

“…W grupie zwierząt doświadczalnych przyjmujących iniekcje ww. ekstraktu w stężeniach 2,5, 5 i 10 mg/kg zaobserwowano zahamowanie tworzenia się obrzęku oraz ograniczenie migracji neutrofili do miejsca zapalnego [44]. W badaniu in vitro przeprowadzonym z wykorzystaniem owczej cyklooksygenazy konstytutywnej (COX-1) oraz owczej cykoosygenazy indukowanej (COX-2) wykazano, że kwas (+)-E-kawoilo-L-jabłkowy, akteozyd, forsytozyd B, arenariozyd i ballotetrozyd wyizolowane z ziela M. vulgare charakteryzują się działaniem hamującym w odniesieniu do izoenzymu COX-2 syntazy cyklicznego nadtlenku prostaglandynowego, uczestniczącego w syntezie cytokin prozapalnych.…”

Cytotoxic activity of methanolic fractions of different Marrubium spp. against melanoma cells is independent of antioxidant activity and total phenolic content

“…A number of biological activities of M. vulgare have been described. It showed hypoglycemic [1], analgesic [2,3], antiphlogistic [4], antihypertensive [5,6] and antioxidant activities, [7,8] and much more [9]. In the group of active compounds among Marrubium species, diterpenoids, sterols and phenylpropanoids (including caffeic acid derivatives and flavonoids) have been reported [10][11][12].…”