Phytochemical Screening and Antibacterial Activity of Tamarindus Indica Pulp Extract

Abukakar, M. G.; Ukwuani, A. N.; Shehu, R.A.

doi:10.3923/ajb.2008.134.138

Cited by 72 publications

(47 citation statements)

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“…The differences in plant species, solvent system used in extraction and part of the plant used may be attributable to the lack of these phytochemicals that were Results were expressed as mean ± standard error mean, n = 6, *= significant (p<0.05), **= highly significant (p<0.01), ***= extremely significant (p<0.001) relative to aspirin used as control, SE = Shedding of epithelium, FH = Frank haemorrhage, PF = Perforation not detected because Dahiru and colleagues [3] have used the methanol root extract of Zizyphus mauritiana instead of the ethanol leaf extract of Zizyphus mucronata used in the present study. The relative less toxicity of the ethanolic leaf extract observed in this study agrees with the report of Abubakar et al [15] in which aqueous extract of the pulp was found to be less toxic. In present study acetylcholine was found to have contractile effect on the isolated rabbit jejenum which was observed to be dose dependent.…”

Section: Discussionsupporting

confidence: 92%

Antiulcer and spasmogenic potential of ethanolic leaf extract of ziziphus mucronata wild in albino rats.

Sy¹

2016

abp

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Ziziphus mucronata has an extensive ethno-botanical use in many areas and has been used for centuries as medicinal plant. The present study was designed to investigate the phytochemical constituents, spasmogenic and antiulcer potential of the ethanolic leaf extract of the plant. The extract was evaluated in White albino rats for anti-ulcer activity and in rabbit jejunum for spasmogenic properties and was found to be relatively less toxic as it contains alkaloids, carbohydrates, cardiac glycosides, glycosides, phlobatannins, saponins, tannins and terpenoids. The protective effects of ethanolic leaf extract of Ziziphus mucronata in aspirin induced epithelial shedding, frank haemorrhage and ulceration was found to be dose dependent. There was no statistically significant difference in the shedding of gastric epithelium between aspirin and the tested doses of the extract (p>0.05). The activity of the extract at 250 mg/kg (p<0.01) and 500 mg/kg (p<0.001) against haemorrhage was found to be statistically significant. However, the activity of the extract at the highest tested dose (500 mg/kg) was found to be better in protecting the stomach from episodic haemorrhage than omeprazole and misoprostol. Further it was observed that 500, 250 and 125 mg/kg of the ethanolic extract had 75, 50 and 25% protection from gastric ulceration respectively, which justifies the use of Ziziphus mucronata as medicinal plant for centuries.

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Section: Discussionsupporting

confidence: 92%

Antiulcer and spasmogenic potential of ethanolic leaf extract of ziziphus mucronata wild in albino rats.

Sy¹

2016

abp

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“…According to Phillipson and O'Neill (1989), (Olajuyigbe and Afolayan, 2012), the aromatic planar quaternary alkaloids present in the extracts can be intercalated with DNA. Lipophilic flavonoids disrupt the integrity of microbial membranes (Tsuchiya et al, 1996), (Olajuyigbe and Afolayan, 2012), tannins precipitate microbial proteins (Prasad et al, 2008), (Olajuyigbe and Afolayan, 2012), and saponins have detergent properties acting as lytic agents of the cell (Abukakar et al, 2008), (Olajuyigbe and Afolayan, 2012). Because these bioactive plant molecules have a precise bacterial metabolic target, their combination in the extracts will cause the attack of several targets simultaneously, which may make the bacteria more susceptible to their effect, hence the observed synergistic action (Vuuren et al, 2011).…”

Section: Evaluation Of the Synergistic Effect Between The Extracts:-mentioning

confidence: 99%

Antibacterial Synergistic Effect of Extracts of the Organs of Capparis Spinosa and in Combination With Antibiotics.

Fatima-Zahra¹,

Filali²,

Moukrad³

et al. 2017

IJAR

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Background:The objective of this study is to test the antibacterial potency and evaluate the possible synergistic effect between aqueous and ethanolic extracts, flower buds and fruits of Capparis spinosa, and between these extracts and antibiotics. Materials and Methods: Antibacterial activity was determined by the plaque microdilution method against seven pathogenic and multiresistant bacteria. Concerning the synergistic effect, between the aqueous and alcoholic extracts of the two organs of this plant, it was carried out according to the "Checkerboard" method. The synergy between the extracts and the antibiotics was estimated by comparing the diameters of the zones of inhibition on solid medium. Results:The extracts showed interesting antibacterial activity with MICs varying from 1.73 ± 0.04 to 66.66 ± 0.00 mg / ml. Both combinations carried between the extracts of flower buds and fruits, ethanolic and aqueous, against Klebsiella pneumoniae and Pseudomonas aeruginosa showed a synergistic effect with ICIF ranging from 0.02 to 0.24. The association between the four extracts and ten antibiotics on the seven strains tested showed an increase in the antibacterial potency of the antibiotic from 11 combinations ranging from 66% to 471%. Conclusion:The present study show that these tested extracts inhibit the growth of Gram-positive and Gram-negative bacteria, which allows us to deduce their broadened spectrum of action and exploit the efficacy of their bioactive molecules as adjuvants to antibiotics.

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“…Some biologically active compounds isolated from herbs have been in use for the inhibition of growth pathogenic microbes because of the resistance against antibiotics [14]. The medicinal values of plants and vegetables are dictated by their phytochemical and other chemical constituents [15].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profiling with Antioxidant and Antimicrobial Screening of <i>Amaranthus viridis</i> L. Leaf and Seed Extracts

Ahmed¹,

Hanif²,

Iftkhar³

2013

OJMM

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Methanol extracts of the dried leaves and seeds of Amaranthus viridis were collected and used for phytochemicals and antibacterial analysis. By detecting the MIC and zone inhibition, the antibacterial activity was determined against different bacterial and fungal strains. The extract yields from the leaves and seeds ranged 5.5 -6.1 and 2.42% -3.72% w/w, respectively. Phytochemical investigation of this plant determines that tanins (6.07% -5.96%), saponins (53% -32%), alkaloids (13.14% -11.42%), protiens (16.76% -24.51%) and glycosides (63.2% -32.3%) were rich in leaves. The extracts also contained appreciable levels of total phenolic contents (2.81 -3.61 GAE, g/100 g), total flavanoid contents (18.4 -5.42 QE, g/100 g) and DPPH free radical scavenging activity, showing IC 50 (83.45 -75.95 µg/mL) along with reducing power was calculated. The MIC of extracts ranged 178 -645 µg/mL. The results of this study suggest the possibility of using the methanolic extracts in treating the diseases caused by the test organisms.

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Phytochemical Screening and Antibacterial Activity of Tamarindus Indica Pulp Extract

Cited by 72 publications

References 1 publication

Antiulcer and spasmogenic potential of ethanolic leaf extract of ziziphus mucronata wild in albino rats.

Antiulcer and spasmogenic potential of ethanolic leaf extract of ziziphus mucronata wild in albino rats.

Antibacterial Synergistic Effect of Extracts of the Organs of Capparis Spinosa and in Combination With Antibiotics.

Phytochemical Profiling with Antioxidant and Antimicrobial Screening of <i>Amaranthus viridis</i> L. Leaf and Seed Extracts

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Phytochemical Screening and Antibacterial Activity of Tamarindus Indica Pulp Extract

Cited by 72 publications

References 1 publication

Antiulcer and spasmogenic potential of ethanolic leaf extract of ziziphus mucronata wild in albino rats.

Antiulcer and spasmogenic potential of ethanolic leaf extract of ziziphus mucronata wild in albino rats.

Antibacterial Synergistic Effect of Extracts of the Organs of Capparis Spinosa and in Combination With Antibiotics.

Phytochemical Profiling with Antioxidant and Antimicrobial Screening of &lt;i&gt;Amaranthus viridis&lt;/i&gt; L. Leaf and Seed Extracts

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Phytochemical Profiling with Antioxidant and Antimicrobial Screening of <i>Amaranthus viridis</i> L. Leaf and Seed Extracts