Phytochemical screening and in vitro evaluation of the antiarthritic activity of Nigella sativa L. seeds extracts

Abstract

This research work aims to investigate the anti-arthritic activity as well as the phytochemical screening of black cumin seed extracts (aqueous and hydroalcoholic) in vitro. The dosage of flavonoids has shown that the content found in the hydroalcoholic extract (134.7 ± 0.289 mg QE/g) was significantly higher compared to the aqueous extract (48.495 ± 0.035mg QE/g). The photochemical tests of the studied seed extracts showed the presence of tannins, saponins and reducing compounds and absence of alkaloids. The results of anti-arthritic activity, showed an important impact of the aqueous and hydroalcoholic extracts inflammation inhibition. This research work revealed that the seed extracts exhibited an important anti-inflammatory effect.