Phytochemical Screening and In vitro Evaluation of Pharmacological Activities of &lt;i&gt;Aphanamixis polystachya&lt;/i&gt; (Wall) Parker Fruit Extracts

Apu, Apurba Sarker; Chowdhury, Farzana; Khatun, Farjana; Jamaluddin, A.T.M.; Pathan, Atiqul Haque; Pal, Arindom

doi:10.4314/tjpr.v12i1.18

Cited by 14 publications

(16 citation statements)

References 10 publications

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“…9 By using thrombolysis medications it is possible to dissolve clots formed in blood vessels. 10,11 Streptokinase Alteplase, Anistreplase, Urokinase and Tissue Plasminogen Activator (TPA) are some of the commonly used thrombolytic drugs all over the world for the treatment of thrombosis [12][13][14] but those drugs has adverse effects like haemorrhage, 15 anaphylactic reaction and lack of specificity. 16 So, scientists are still trying to develop the medicine from various plants and animal sources which must have thrombolytic, [17][18][19] antiplatelet, 20,21 antithrombotic 22 and anticoagulant activity 23,24 along with less side effects.…”

Section: Introductionmentioning

confidence: 99%

Estimation of phytochemical, antioxidant screening profile and thrombolytic activities of methanolic extract of Antidesma bunius L. leaf

Islam¹,

Munira²,

Zaman³

et al. 2018

HIJ

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A. bunius tree is shrubby, generally height in between 10 to 26 ft. (3-8 m) but it can extend up to 50 or even 100 ft. (15-30 m). Leaves are shaped like oblong which is 4 to 9 inch (10-22.5 cm) long, 2 to 3 inch (5-7.5 cm) wide. The tree is tiny, odorous, reddish and axillary racemes are 3 to 8 inch (7.5-20cm) long. Fruits of this plant are shaped like round or ovoid and taste acidic, slightly sweet. For some people it taste like bitter, straw-colored stone, an irregular, flattened oval, ridged, very hard, 3/8 in (1 cm) long, 1/4 in (6 mm) wide. 3

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Section: Introductionmentioning

confidence: 99%

Estimation of phytochemical, antioxidant screening profile and thrombolytic activities of methanolic extract of Antidesma bunius L. leaf

Islam¹,

Munira²,

Zaman³

et al. 2018

HIJ

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“…In the present investigation the preliminary phytochemical studies serves as groundwork to isolate the pharmacologically active principles present in the plant. Previous researchers have reported the antibacterial activities of the leaves [18][19], Fruit [8], Bark [20][21]of the plant. The current result also correlates with the previous studies.…”

Section: Disscussionmentioning

confidence: 99%

“…It is widely distributed in higher altitudes in Western Ghats and Eastern Ghats of South India, rarely found in Sub Himalayan tracks from upper area going eastwards to Bengal, Sikkim and Assam [4,6,7] . The plant extract possess Anti-oxidant, Thrombolytic activity [8], Anticancer [9][10], Insecticidal, Antifeedant [11], Laxative [7] and Anti-microbial [12]. The present study is aimed to screen for phytochemicals and to evaluate antibacterial activity of crude extracts of Amoora ruhituka bark and to find out minimum inhibitory concentration (MIC) of different extracts against Garm negative bacteria.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Antibacterial Evaluation of Various Extracts of <i>Amoora ruhituka</i> Bark

Umesh

Sanjeevkumar

Londonkar

2015

ILNS

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ABSTRACT. Preliminary phytochemical screening of various extracts of Amoora ruhituka bark were investigated which reveals the presence of several secondary metabolites in each extracts. The antibacterial activity of all the extracts was tested against four gram negative bacterial strains. The results indicated the zone of inhibition which ranges from 11.30±577 to 18.7±0.577 for different extracts in which Methanol extract has shown highest zone of inhibition for Salmonella typhimurium followed by Enterobacter aerogenes , E coli and P aeruginosa whereas benzene extract has showed the least zone of inhibition and the minimum inhibitory concentration (MIC) of the different extracts ranging from 0.78 mg/ml to 6.25mg/ml.The complete results of this study provides a essential data for the use of Amoora ruhituka for the treatment of infection associated diseases

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“…[2] Thrombolytic agents are used to dissolve the clot and in the management of thrombosis in patients. [3] Thrombolytic agents such as tissue plasminogen activator, urokinase, and streptokinase (SK) [4] are used all over the world for the treatment, [5] but their use is associated with hyper risk of hemorrhage, [6] anaphylactic reaction, and lacks specificity. Remarkable efforts have been made toward the discovery and development of natural constituents from various plant and animal sources which have antiplatelet, [7][8] anticoagulant, [9][10] antithrombotic, [11] and thrombolytic activity.…”

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confidence: 99%

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Mamillapalli¹

2019

IJGP

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Aim: The aim of the study was to carry out total phenolic content determination followed by in vitro thrombolytic studies of aqueous and alcoholic extracts of Cassia siamea L., extracts and pyrogallol. Materials and Methods: The plant leaf aqueous and alcoholic extractive values, preliminary phytochemical screening followed by total phenolic content was determined. Further, the plant extracts and one of the plant active constituents' pyrogallol were studied for in vitro thrombolytic activity using streptokinase (SK) as standard in human venous blood. Results and Discussion: The extractive values were found to be 15.0 and 13.2 w/w for aqueous and alcoholic extracts. The plant extracts showed the presence of phenolics and flavonoids. The total phenolic components present in aqueous and alcoholic extracts were found to be 3 mg/g and 0.3 mg/g equivalent of pyrogallol. The aqueous extract contains more amount of phenolic substances than alcoholic extract. The percentage clot lysis was found to be 2.25% in standard SK, 14.50% in aqueous extract, 18% in the ethanolic extract, and 17.75% in pyrogallol, respectively. The ethanolic extract exhibited better thrombolytic activity than aqueous extract. Pyrogallol also exhibited equivalent thrombolytic activity compared to standard. Conclusion: The results indicate that ethanolic extract exhibited thrombolytic activity which may be due to hydrolysable tannin pyrogallol. Further studies are required to isolate the responsible component from the ethanolic extract and pyrogallol can be studied for mechanism of action studies.

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Phytochemical Screening and In vitro Evaluation of Pharmacological Activities of <i>Aphanamixis polystachya</i> (Wall) Parker Fruit Extracts

Cited by 14 publications

References 10 publications

Estimation of phytochemical, antioxidant screening profile and thrombolytic activities of methanolic extract of Antidesma bunius L. leaf

Estimation of phytochemical, antioxidant screening profile and thrombolytic activities of methanolic extract of Antidesma bunius L. leaf

Phytochemical and Antibacterial Evaluation of Various Extracts of <i>Amoora ruhituka</i> Bark

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