Phytochemical Screening and the Antimicrobial and Antioxidant Activities of Medicinal Plants of Meru Betiri National Park – Indonesia

Nugraha, Ari Satia; Permatasari, Agka Enggar Niken; Kadarwenny, Carina Puspita; Pratoko, Dwi Koko; Triatmoko, Bawon; Rosyidi, Viddy Agustian; Norcahyanti, Ika; Dewi, Ika Puspita; Dianasari, Dewi; Sary, Indah Purnama; Wangchuk, Phurpa

doi:10.1080/10496475.2020.1734136

Cited by 12 publications

(7 citation statements)

References 18 publications

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“…8 The archipelagic country of Indonesia is covered by the second largest biodiversity in the world, including 6000 recorded medicinal plants. 9 Previous notable antimalarial discoveries from Indonesia include treatments arising from ethnopharmacology field trips from islands with malaria-endemic cases. 10 These studies provide foundations for the discovery of new antimalarial agents from Indonesian medicinal plants.…”

Section: Introductionmentioning

confidence: 99%

Isolation of Antimalarial Agents From Indonesian Medicinal Plants: Swietenia mahagoni and Pluchea indica

Nugraha

Purnomo

Pratama

et al. 2022

Natural Product Communications

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Malaria is a neglected tropical disease that still demands serious efforts to tackle successfully, including the need for new antimalarial lead compounds to combat drug-resistant Plasmodium. Intensive phytochemical and pharmacological investigation into the Indonesian medicinal plants Swietenia mahagoni and Pluchea indica successfully revealed 5 constituents. Antimalarial bioassays indicated 34,5-tri- O-caffeoylquinic acid (4) to be the most active against Plasmodium falciparum 3D7 and Dd2 strains with IC50 values of 8.2 and 8.8 µM, respectively. No cytotoxicity was observed against Human Embryonic Kidney cells at a concentration of 40 µM.

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Section: Introductionmentioning

confidence: 99%

Isolation of Antimalarial Agents From Indonesian Medicinal Plants: Swietenia mahagoni and Pluchea indica

Nugraha

Purnomo

Pratama

et al. 2022

Natural Product Communications

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“…Plant extracts were prepared using the previously described method [ 41 , 43 , 75 , 76 ]. Briefly, for each sample, 25 grams (g) of the dried coarse powdered sample (ground using a NutriBullet) were extracted with 150 mL 80% ethanol and left for 2 h (constantly stirring).…”

Section: Methodsmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Activities of Endemic Plants of the Australian Wet Tropics

Yeshi

Ruscher

Miles

et al. 2022

Plants

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Plants have been a vital source of natural antioxidants since ancient times. Plants growing under various abiotic stress conditions often produce more defensive secondary metabolites such as phenolics, flavonoids, and terpenoids during adaptation to the environment. Many of these secondary metabolites are known to possess antioxidant and anti-inflammatory properties. This study tested seven plants sourced from the mountaintop areas (above 1000 m elevation) of Mount Lewis National Park (falls under the Wet Tropics of Queensland), Australia, for their antioxidant and anti-inflammatory activities. Of the seven studied plants, hydroethanolic extracts of six plants (Leptospermum wooroonooran, Ceratopetalum hylandii, Linospadix apetiolatus, Garcinia brassii, Litsea granitica, and Polyscias willmottii) showed high 2,2-diphenyl-1-picrylhydrazyl (DPPH)-free radical scavenging activity in a dose-dependent (25–1000 μg/mL) manner. At the highest concentration of 1 mg/mL, the DPPH free radical scavenged percentage varied between 75.4% and 92.3%. Only the species Alyxia orophila was inactive in the DPPH free radical scavenging assay. Pseudo-IC50 values of the extracts’ ferric reducing antioxidant power (FRAP) based on dose-response curves showed a significant positive correlation with total phenolic content. Five out of the seven plants, namely G. brassii, C. hylandii, L. apetiolatus, L. wooroonooran, and A. orophila, showed inhibitory effects on the secretion of proinflammatory cytokines, tumour necrosis factor (TNF), and interleukins (IL)-23 in a lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMCs) assay. The results of this study demonstrate the value of tropical mountaintop plants in the biodiscovery of antioxidant and anti-inflammatory lead compounds.

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“…[ 33 , 34 ], Pandanus tectorius Parkinson [ 35 ], the true mangrove Nypa fruticans Wurm. [ 35 ], Areca catechu L. [ 31 ], Phragmites vallatoria Veldkamp [ 36 ], Ruppia maritima L. [ 37 ], and Flagellaria indica L. [ 38 ]. The ethanol extract of Flagellaria indica L. at the concentration of 12.5 µg/mL repressed DV by 45.5% [ 39 , 40 ].…”

Section: Distribution Of Antibacterial Antifungal and Antiviral Princ...mentioning

confidence: 99%

Antimicrobial Secondary Metabolites from the Mangrove Plants of Asia and the Pacific

et al. 2022

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Microbes such as the White Spot Syndrome Virus account for severe losses in the shrimp farming industry globally. This review examines the literature on the mangrove plants of Asia and the Pacific with antibacterial, antifungal, or antiviral activities. All of the available data published on this subject were collected from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem, and a library search from 1968 to 2022. Out of about 286 plant species, 119 exhibited antimicrobial effects, and a total of 114 antimicrobial natural products have been identified including 12 with MIC values below 1 µg/mL. Most of these plants are medicinal. The mangrove plants of Asia and the Pacific yield secondary metabolites with the potential to mitigate infectious diseases in shrimp aquaculture.

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Phytochemical Screening and the Antimicrobial and Antioxidant Activities of Medicinal Plants of Meru Betiri National Park – Indonesia

Cited by 12 publications

References 18 publications

Isolation of Antimalarial Agents From Indonesian Medicinal Plants: Swietenia mahagoni and Pluchea indica

Isolation of Antimalarial Agents From Indonesian Medicinal Plants: Swietenia mahagoni and Pluchea indica

Antioxidant and Anti-Inflammatory Activities of Endemic Plants of the Australian Wet Tropics

Antimicrobial Secondary Metabolites from the Mangrove Plants of Asia and the Pacific

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