Phytochemical screening and toxicological profile of methanolic extract ofPicralima nitidafruit-rind (Apocynaceae)

Mabeku, Laure B. Kouitcheu; Kouam, Jacques; Paul, Arpita; Etoa, François–Xavier

doi:10.1080/02772240701747556

Cited by 19 publications

(5 citation statements)

References 16 publications

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“…These secondary metabolites present in the stem barks of Picralima nitida matches with the reports of Kouitcheu-Mabeku et al [51], Igboasoiyi and Essien [52], and Teugwa et al [53] who also reported the presence of flavonoids, saponins, tannins, alkaloids and glycosides. Obasi et al [12] reported similar compounds with the dearth of phenol in the peel of picralima nitida whereas Aghedo et al [54] observed the same with tannins absent.…”

Section: Discussionsupporting

confidence: 90%

Phytochemical Screening and Gas Chromatography-Mass Spectrometry Analysis of Bioactive Compounds Present in Stem Bark of Picralima nitida (stapf)

Onwuegbuchulam,

Peter,

Moses

2024

JDMP

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Over the years, traditional societies and ethnic nationalities have engaged plants with medicinal properties for the treatment of a range of diseases without any scientific knowledge of it inherent bioactive compounds that are responsible for its medicinal and pharmacological potentials. The aim of this study is to screen for the presence of phytochemical constituents and to identify the bioactive compounds domicile in the stem bark of Picralima nitida by the use of Gas Chromatography - Mass Spectrometry. The result of the quantitative investigation of the stem bark extract of P. nitida showed the presence of some phytochemical compounds such as saponins (3.22%), alkaloids (2.43%), flavonoids (6.05%) tannins (6.25%), oxalate (12.70%), phytate (2.87%), anthracene glycosides (2.14%) and cyanogenic glycosides (1.37%). Eleven (11) different bioactive compounds were recognized in the stem bark extract of P. nitida by Gas Chromatography - Mass Spectrometry analysis. The percentage of major bioactive compounds were vitamin E (69.31%), Cis-Myrtanol (5.57%), Octadecanoic acid methyl ester (4.52%), 11-Octadecenoic acid methyl ester (4.42%), 9-Methyl-2-phenyl-9H-imidazo (1,2-a) benzimidazole (3.70%), Pentadecanoic acid 14-methyl- methylester (3.21%) and 7,9-Dimethyl-6H-Indolo (2,3-b) quinoxaline (3.11%). From these findings, it could be concluded that P. nitida stem bark is rich in various bioactive compounds which possess antioxidant, laxative and other diverse medicinal properties. Therefore, it can be recommended as a plant of phytomedicinal value.

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Section: Discussionsupporting

confidence: 90%

Phytochemical Screening and Gas Chromatography-Mass Spectrometry Analysis of Bioactive Compounds Present in Stem Bark of Picralima nitida (stapf)

Onwuegbuchulam,

Peter,

Moses

2024

JDMP

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“…Subacute toxicity: Toxic effect on the liver, kidneys and the lungs (Kouitcheu Mabeku et al, 2008). Pancreas degeneration in methanol seeds extract treated groups (Akinloye et al, 2014) Akuammicine, 10-deoxyakuammine, akuammine, akuammidine, burnamine and picraline (Teugwa et al, 2013) Apocynaceae: Rauvolfia vomitoria Afzel.…”

Section: Not Available In Literaturementioning

confidence: 99%

An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

Taika

Bouckandou

Souza

et al. 2018

Journal of Ethnopharmacology

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“…Akuamma seed contain many organic compounds, such as phenolics, terpenoids and tannins in considerable amount [22]. While saponins, flavornoids and alkaloids are identified in moderate amount to scavenge free radicals and indole detoxification [23,24]. Before now, there is no reported work on inhibitive effects of Akuamma seed extract on acidic corrosion of aluminum.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Akuamma Seed Extract on Corrosion Inhibition of Aluminum in Hydrochloric Acid Pickling Environment

Ezeugo

Onukwuli

Ikebudu

et al. 2019

EJCS

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Inhibitive impact of Akuamma seed (AS) extract toward 1.0M HCl corrosion of aluminum was examined using response surface methodology (RSM). Gravimetric (weight loss), potentiodynamic polarization and electrochemical impedance spectroscopy techniques were used in the corrosion inhibition process. In all the method used, the seed extract acted as good corrosion inhibitor of aluminum in 1.0M HCl solution. Optimal inhibition efficiency of 72.6% was obtained at optimum inhibition concentration of 1.2g/l, temperature of 304.19k and maximized time of 11.53hrs. It showed that the plant extract has excellent inhibitive properties for the corrosion inhibition process. The values of kads are relatively small indicating that the interaction between the adsorbed extract molecules and aluminum surface is a physical process. The (AS) extract protects aluminum against pitting corrosion. The level of protection increases with increase extract concentrations. The extract inhibited both cathodic and anodic reactions and acted as mixed-type inhibitor.

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Phytochemical screening and toxicological profile of methanolic extract ofPicralima nitidafruit-rind (Apocynaceae)

Cited by 19 publications

References 16 publications

Phytochemical Screening and Gas Chromatography-Mass Spectrometry Analysis of Bioactive Compounds Present in Stem Bark of <i>Picralima nitida </i>(stapf)

Phytochemical Screening and Gas Chromatography-Mass Spectrometry Analysis of Bioactive Compounds Present in Stem Bark of <i>Picralima nitida </i>(stapf)

An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

Investigation of Akuamma Seed Extract on Corrosion Inhibition of Aluminum in Hydrochloric Acid Pickling Environment

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Phytochemical screening and toxicological profile of methanolic extract ofPicralima nitidafruit-rind (Apocynaceae)

Cited by 19 publications

References 16 publications

Phytochemical Screening and Gas Chromatography-Mass Spectrometry Analysis of Bioactive Compounds Present in Stem Bark of &lt;i&gt;Picralima nitida &lt;/i&gt;(stapf)

Phytochemical Screening and Gas Chromatography-Mass Spectrometry Analysis of Bioactive Compounds Present in Stem Bark of &lt;i&gt;Picralima nitida &lt;/i&gt;(stapf)

An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

Investigation of Akuamma Seed Extract on Corrosion Inhibition of Aluminum in Hydrochloric Acid Pickling Environment

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Phytochemical Screening and Gas Chromatography-Mass Spectrometry Analysis of Bioactive Compounds Present in Stem Bark of <i>Picralima nitida </i>(stapf)

Phytochemical Screening and Gas Chromatography-Mass Spectrometry Analysis of Bioactive Compounds Present in Stem Bark of <i>Picralima nitida </i>(stapf)