Phytochemical Study and Anxiolytic activity of Hibiscus cannabinus leaves

Jadhav, Chitrarekha A; Jadhav, Ravindra S.; Vikhe, S R

doi:10.52711/0975-4385.2022.00046

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…We then leverage the LDM technique to help us obtain the stiffness and damping parameters for the dynamic model acquired from PRBM. LDM quantifies the rate of reduction of the oscillating amplitude of a system [39], providing a measure of the system's damping characteristics. Onwards, this manuscript will refer to the coupled method of Pseudo-Rigid Body Modeling and Logarithmic Decrement as the PRBM+LDM method.…”

Section: Introductionmentioning

confidence: 99%

Toward precise force control of soft hand grasping: The viscoelastic parameter estimation of pseudo-soft-rigid-model by applying logarithmic decrement method

Zhang,

Heung,

Deshpande

et al. 2024

Preprint

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The rapid advancement in physical human-robot interaction (HRI) has propelled the growth of soft robot design and, in parallel, soft robot controllers. Controlling soft robots is complex due to their wide range of movements, prompting the use of simplified model-based controllers to provide sufficient information for real-time high dynamic response control performance. However, most modeling techniques face computational efficiency and complexity of parameter identification issues and are hard to apply to real-time controls. To alleviate this, we employ a coupled analytical modeling approach based on Pseudo-Rigid Body Modeling and the Logarithmic Decrement Method for parameter estimation (PRBM+LDM). Using a soft robot hand test bed, we demonstrate the accuracy of PRBM+LDM to model position and force output as a function of pressure input and benchmark its performance. We, then, apply the PRBM+LDM model as a basis for a closed-loop position controller and compare its performance against a simple PID controller. Furthermore, we apply the PRBM+LDM model as a closed-loop force controller and compare its performance with simple constant pressure grasping control by performing small contact areas pinching tasks on low-weight, small objects - a screwdriver, a potato chip, and a brass coin. The PRBM+LDM-based position controller (Average Max. Error across all fingers: 4.37°) outperformed the simple PID position controller (Average Max. Error across all fingers: 20.38°). Furthermore, the PRBM+LDM-based force controller (Potato chip: 86%, Screwdriver: 74.42%, Brass coin: 64.75%) achieved a higher success rate than the constant pressure grasping control (Potato chip: 82.5%, Screwdriver: 70%, Brass coin: 35%) in the pinching tasks. We conclude that the PRBM+LDM modeling technique proves to be a convenient and efficient way to model the dynamic behavior of soft actuators closely and can be used to build high-precision position and force controllers. In application, it realizes stable, flexible grasping of small objects by exerting precise contact force on contact areas.

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Section: Introductionmentioning

confidence: 99%

Toward precise force control of soft hand grasping: The viscoelastic parameter estimation of pseudo-soft-rigid-model by applying logarithmic decrement method

Zhang,

Heung,

Deshpande

et al. 2024

Preprint

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show abstract

“…ROS is also known to induce cellular oxidative stress that contributes to infectious and various inflammatory illnesses such as arthritis, joint pain etc. Inflammatory conditions such as arthritis are typically addressed using non‐steroidal anti‐inflammatory drugs (NSAIDs), corticosteroids, and disease‐modifying anti‐rheumatic drugs (DMARDs) [12] . However, these medications often result in severe side effects.…”

Section: Introductionmentioning

confidence: 99%

“…Inflammatory conditions such as arthritis are typically addressed using non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and disease-modifying anti-rheumatic drugs (DMARDs). [12] However, these medications often result in severe side effects. Essential defense cells, including mononuclear and polymorphonuclear leukocytes, generate excessive ROS in their efforts to protect the body.…”

Section: Introductionmentioning

confidence: 99%

Lipidomic Profiling and Pharmacological Activities of Ficus drupacea Oil: Comparative Study Between Conventional vs. Green Solvent

Kansal,

Shukla,

Shukla

2024

Chemistry & Biodiversity

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Ficus drupacea is a medicinal tree found in temperate regions. Various parts of this plant had been used traditionally for the treatment of various ailments such as root powder applied externally for skin infections. Analysis was carried out on the bioactive lipids extracted from Ficus drupacea fruit using both petroleum‐based solvent (Hexane) and an environmentally friendly solvent Dimethyl carbonate (DMC). The results showed that DMC extraction yielded a high oil content in Ficus drupacea fruit (6.51%). When examining the fatty acid composition using GC‐FID analysis, Ficus drupacea oil extracted with DMC contained significant proportions of essential fatty acids such as linoleic acid (32.317%), oleic acid (20.946%), palmitic acid (25.841%), etc. Additionally, DMC extraction resulted in higher levels of total phenolics in Ficus drupacea fruit oil compared to hexane. Moreover, DMC extracted oil exhibited stronger antioxidant properties, such as radical scavenging, anti‐ arthritic, photoprotective activity while displayed similar anti‐inflammatory and anti‐microbial activity as hexane‐extracted oil. In summary, these findings demonstrate that DMC is an efficient and safer alternative to conventional solvent hexane for extracting oils from Ficus drupacea fruit. It is rich in bioactive compounds essential for human nutrition, including polyunsaturated fatty acids, flavonoids, and phenolic compounds, with enhanced biological activities.

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Evaluation of Zinc acetate in decreasing anxiety like behavior in Swiss Albino Mice using behavior model

2024

RJPT

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Anxiety disorder is one of the most commonly occurring mental health conditions with less visibility leading to profound disability. Zinc, one of the most ubiquitous trace elements, has been identified to interact with the glutamate and GABAA receptors. This study was conducted to assess the anxiolytic activity of zinc acetate using a various behavioural model. Swiss albino mice were used in this study. The mice were randomised into 5 groups and were treated with control- normal saline, Diazepam as a standard drug, zinc acetate (10 and 20mg/kg) and zinc acetate 10mg/kg + Diazepam. Their anxiety like behaviour was assessed using elevated plus maze. In the elevated plus maze, zinc acetate at 20mg/kg and zinc acetate 10mg/kg + Diazepam showed increased amount of time spent in the open arm and also the number of entries into the open arm. Statistical analysis was performed using unpaired t- test. In conclusion, zinc acetate decreases anxiety like behaviour in mice and also potentiates the action of Diazepam.

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Phytochemical Study and Anxiolytic activity of Hibiscus cannabinus leaves

Cited by 3 publications

References 9 publications

Toward precise force control of soft hand grasping: The viscoelastic parameter estimation of pseudo-soft-rigid-model by applying logarithmic decrement method

Toward precise force control of soft hand grasping: The viscoelastic parameter estimation of pseudo-soft-rigid-model by applying logarithmic decrement method

Lipidomic Profiling and Pharmacological Activities of Ficus drupacea Oil: Comparative Study Between Conventional vs. Green Solvent

Evaluation of Zinc acetate in decreasing anxiety like behavior in Swiss Albino Mice using behavior model

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