Phytochemical study, cytotoxic, analgesic, antipyretic and anti-inflammatory activities of Strychnos nux-vomica

Abstract

The strychnine tree (Strychnos nux-vomica L.) (S. nux-vomica) belonging to family Loganiaceae has been a very promising medication for certain disorders. Different chromatographic methods were used to isolate the phenolic compounds from the aqueous methanolic extract of the S. nux-vomica leaves. Their identification was achieved through spectroscopic techniques. Cytotoxicity, analgesic, antipyretic and anti-inflammatory activities of S. nuxvomica leaves extract were evaluated. Five phenolic compounds were isolated and identified; Kaempferol-7 glucoside 1, 7-Hydroxy coumarin 2, Quercetin-3-rhamnoside 3, Kaempferol 3-rutinoside 4, and Rutin 5. Furthermore, the cytotoxic activity of the extract was evaluated against different cancer cell lines. The extract showed potential cytotoxic activity against human epidermoid larynx carcinoma cells (Hep-2) and against breast carcinoma cell line (MCF-7). Colon carcinoma cells (HCT) were the least one affected by the extract. In addition, the extract exhibited promising analgesic, antipyretic as well as anti-inflammatory activities. It is concluded that, leaves extract of S. nux vomica possess potent cytotoxic, analgesic, antipyretic and anti-inflammatory activities. These activities could be due to the presence of phenolic compounds revealed by our phytochemical investigations.

Anti‐inflammatory and diuretic effects of the diterpene ent‐dihydrotucumanoic acid

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Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

“…Reactive oxygen species (ROS) are continuously generated inside the mammalian body as a result of exposure to many exogenous chemicals, xenobiotics and drugs in our environment and/or endogenous metabolic events involving electron transport mechanism and redox enzymes (Al-Sayed et al 2014;Eldahshan and Abdel-Daim 2014;Abdel-Daim 2014). In normal conditions, there is balance between the ROS produced and the antioxidants, as the ROS generated are neutralized by the endogenous antioxidants (Sun 1990).…”

Therapeutic effects of Qian-Yu decoction and its three extracts on carrageenan-induced chronic prostatitis/chronic pelvic pain syndrome in rats

“…Carrageenan is a highly sulfated polygalactan with 15-40% of ester-sulfate content and an average molecular weight well above 100 kDa [27]. Carrageenan has been widely used to induce inflammation in animal models and human cells [28, 29]. Carrageenan triggers inflammatory cascades in which Toll-like receptor 4 (TLR4) and B-cell leukemia/lymphoma 10 (BCL10) are critical [30, 31].…”