Phytochemistry and Biological Properties of Burnet Weed (&lt;i&gt;Sanguisorba&lt;/i&gt; spp.): A Review

Karkanis, Anestis; Vellios, Evangelos; THOMAIDIS, Thomas; Bilalis, Dimitrios; Efthimiadou, Αspasia; Travlos, Ilias

doi:10.15835/nsb649471

Cited by 24 publications

(23 citation statements)

References 35 publications

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“…1 The species is widely distributed throughout Europe and is commonly found in dry and semi-dry grasslands of the Mediterranean basin. 2,3 S. minor and other species of this genus (e.g. S. officinalis) are commonly used as medicinal species, while they are also edible and their young shoots and leaves are usually used in mixed vegetable salads.…”

Section: Introductionmentioning

confidence: 99%

“…S. officinalis) are commonly used as medicinal species, while they are also edible and their young shoots and leaves are usually used in mixed vegetable salads. 2,4,5 Plants grown in the wild are also used as forage species due to their high nutritional value, dry matter digestibility and metabolizable energy. 6 Sanguisorba species are rich sources of secondary metabolites with significant bioactive properties.…”

Section: Introductionmentioning

confidence: 99%

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Chemical composition and bioactive properties of Sanguisorba minor Scop. under Mediterranean growing conditions

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical composition and bioactive properties of Sanguisorba minor Scop. under Mediterranean growing conditions

et al. 2019

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“…Studies have indicated that Sanguisorba spp. extracts inhibit AChE activity and the glycogen synthase kinase 3β (GSK3) (19,20). Both of these enzymes have important roles in AD (21).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of Sanguisorba minor and Ferulago angulata total extracts against beta-amyloid induced cytotoxicity and oxidative stress in cultured cerebellar granule neurons

Akbari

Soodi

Hajimehdipoor

et al. 2019

J Herbmed Pharmacol

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Introduction: Alzheimer’s disease (AD) is an age-dependent neurodegenerative disorder and major cause of mortality in the elderly. AD has a complex pathophysiology and needs new multi-targeted compounds to halt the disease progression through several mechanisms. Medicinal plants contain various compounds with heterogeneous pharmacological effects, therefore are a good source. The aim of this study was to evaluate the protective effect of total extracts of Sanguisorba minor and Ferulago angulata on beta-amyloid (Aβ)-induced toxicity in primary neural cell culture.Methods: Cerebellar granule neurons (CGNs) were cultured according to standard protocols. The cultured neurons were incubated with Aβ alone or in combination with different concentrations of extracts for 24 hours. Cell viability was measured by methylthiazolyldiphenyl-tetrazolium (MTT) assay. In addition acetylcholinesterase (AChE) activity and oxidative stress markers were measured after incubation. Also, the effects of different concentrations of the extracts on AChE activity of the cultured neurons were investigated. For measuring the acute toxicity of the extract, LD50 was estimated by limit test.Results: Both extracts could protect CGNs against Aβ-induced cell death. Aβ-induced oxidative stress and increase of AChE activity were ameliorated by both extracts. S. minor extract dose-dependently reduced AChE activity in cultured CGNs. LD50 of both extracts was estimated above 2000 mg/kg and considered as safe.Conclusion: Both studied extracts protected CGNs against Aβ-induced toxicity by ameliorating oxidative stress mechanism. According to these results, these extracts are recommended for further investigation in AD treatment.

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“…Sanguisorba officinalis L. is a member of the Rosaceae family and is a widely distributed perennial weed worldwide [ 9 ]. Edible dried roots of S. officinalis L. (known as JiYu in Korea and Japan or DiYu in China) have been used as a herbal medicine for centuries.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antioxidant and Anti-Propionibacterium acnes Activities of Cold Water, Hot Water, and Methanol Extracts, and Their Respective Ethyl Acetate Fractions, from Sanguisorba officinalis L. Roots

Kim

Noh

et al. 2018

Molecules

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Identification of medicinal plants and naturally derived compounds as new natural antioxidant and antibacterial sources for topical acne treatment has long been important. To determine anti-Propionibacterium acnes activity and in vitro antioxidant activities, Sanguisorba officinalis L. root (SOR) was extracted with cold water (CWE), hot water (HWE), and methanol (ME), and each extract was fractionated successively with hexane, ethyl acetate (EA), and butanol to determine whether the activities could be attributed to the total phenolic, flavonoid, terpenoid, and condensed tannin contents. Pearson’s correlation coefficients were analyzed between the respective variables. The SOR CWE, HWE, ME, and their respective EA fractions showed anti-P. acnes activity based on the paper disc diffusion method on agar plates, minimum inhibitory concentration (MIC), and minimal bactericidal concentration (MBC). The MIC against P. acnes had a moderate (+) correlation with the total phenolic content, but not with the other measures. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging capacity (SC) had a strong (–) correlation with the total phenolic content and a moderate (–) correlation with the total flavonoid content. The total antioxidant capacity had a strong (+) correlation with the condensed tannin content. Linoleic acid peroxidation inhibition had a strong (–) correlation with the total phenolic content. To elucidate the major active phytochemicals in the CWE-EA, HWE-EA, and ME-EA fractions, high performance liquid chromatography-ultraviolet (HPLC-UV) and ultra high performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) were performed. The HPLC-UV analysis showed the presence of nine compounds in common (arjunic acid and/or euscaphic acid, gallic acid, kaempferol, caffeic acid, ferulic acid, tannic acid, and coumarin, quercetin). The UHPLC-QTOF-MS analysis showed the presence of nine compounds in common (gallic acid; caffeic acid; umbelliferone; arjunic acid, euscaphic acid, and/or tormentic acid; pomolic acid; rosamultic acid; and benzoic acid). When standards of the identified phytochemicals were tested against the same bacterium, quercetin, coumarin, and euscaphic acid showed antibacterial activity against P. acnes.

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Phytochemistry and Biological Properties of Burnet Weed (<i>Sanguisorba</i> spp.): A Review

Cited by 24 publications

References 35 publications

Chemical composition and bioactive properties of Sanguisorba minor Scop. under Mediterranean growing conditions

Chemical composition and bioactive properties of Sanguisorba minor Scop. under Mediterranean growing conditions

Protective effects of Sanguisorba minor and Ferulago angulata total extracts against beta-amyloid induced cytotoxicity and oxidative stress in cultured cerebellar granule neurons

In Vitro Antioxidant and Anti-Propionibacterium acnes Activities of Cold Water, Hot Water, and Methanol Extracts, and Their Respective Ethyl Acetate Fractions, from Sanguisorba officinalis L. Roots

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