Phytochemistry and pharmacological properties of Ruta graveolens L.

Asgarpanah, Jinous; Khoshkam, Roghaieh

doi:10.5897/jmpr12.040

Cited by 78 publications

(77 citation statements)

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“…Myrtucommulone and semi‐myrtucommulone, extracted from myrtle ( M. communis ) leaves, suppress the biosynthesis of PGs and Leukotrienes, the release of leukocyte elastase, and the formation of peroxides, which are responsible for inflammatory processes (Asgarpanah and Ariamanesh, ). The natural acylphloroglucinol myrtucommulone‐A inhibits microsomal prostaglandin E 2 synthase‐1 and 5‐lipoxygenase (5‐LO) (Wiechmann et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Herbal Medicines in Idiopathic Heavy Menstrual Bleeding: A Systematic Review

et al. 2016

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Idiopathic heavy menstrual bleeding (HMB; IHMB) is a common gynecological problem with no pelvic pathology or general bleeding disorder. Herbal remedies are commonly used to treat HMB. This systematic review aimed to assess the effectiveness and safety of herbal preparations for the treatment of IHMB. MEDLINE, Ovid, and the Cochrane Central Register of Controlled Trials were searched from inception to 23 August 2015. Only randomized controlled trials were considered. Three randomized controlled trials were included in this systematic review. Different herbal preparations were used in the included trials. In two studies, Ginger capsules and myrtle fruit syrup significantly reduced the menstrual duration and blood loss compared with placebo based on the pictorial blood loss assessment chart score (p < 0.001, p = 0.01). In another trial, Punica granatum flower capsules were as effective as tranexamic acid capsules in reducing the mean (SD) pictorial blood loss assessment chart score, with no significant difference between the two treatments (p = 0.3). The results show that the methods used in these trials may reduce menstrual bleeding in women with IHMB. Additional well-designed trials are needed to investigate the safety and efficacy of herbs for the treatment of women with IHMB or other forms of HMB.

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Section: Discussionmentioning

confidence: 97%

Herbal Medicines in Idiopathic Heavy Menstrual Bleeding: A Systematic Review

et al. 2016

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“…Nonetheless, several new features have been described for this medicinal plant, including its protective effect against DNA strand breakage and mutagenesis. Moreover, rue has been shown to induce the removal of an amide group from the antiapoptotic protein Bcl-xL in human brain cancer cells, but not in normal B and T lymphocytes, thus increasing the sensitivity of cancer cells to death, while leaving normal cells unaffected [44].…”

Section: Ruementioning

confidence: 99%

Apoptotic Activities of Mediterranean Plant Species

Rı́os

2015

The Mediterranean Diet

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“…Park et al (2010), in their study, investigated the antinociception effect and mechanism of R. graveolens L. in mice and reported that the plant species has antinociception property which may be underpinned by opioidergic and alpha 2 -adrenergic receptors. Asgarpanah and Khoshkam (2012) in their paper reviewed various studies on the phytochemistry and pharmacological properties of R. graveolens L. and showed that the plant species has been used in the treatment of painful and inflammatory conditions. Despite all these reports, little information exists on studies on the mechanism of antinociception activity of R. graveolens as shown by Park et al (2010), and none was found regarding possible mechanism (s) of the anti-inflammatory and antipyretic activities of the plant species especially using the drug interaction methods.…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive, Anti-Inflammatory and Antipyretic Activities of the Leaf Methanol Extract of <i>Ruta Graveolens</i> L. (Rutaceae) in Mice and Rats

Loonat

Amabeoku

2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Ruta graveolens has been used to treat toothache, earache, rheumatism and fever with little scientific evidence corroborating these uses. Materials and Methods:The leaf methanol extract of Ruta graveolens was evaluated for antinociceptive activity using the acetic acid writhing and hot-plate tests in mice, also anti-inflammatory and antipyretic activities using the carrageenan-induced oedema and E. coli-induced pyrexia tests in rats, respectively. Results: R. graveolens (100 mg/kg, i.p.), significantly reduced the number of acetic acid-induced writhes by 54 %. R. graveolens (400 mg/kg, i.p.), significantly delayed the reaction time in mice to thermal stimulation 15, 30, 45, and 60 min after treatment. Combined treatment of the lowest and sub-effective doses of the leaf methanol extract (25 mg/kg, i.p.), and indomethacin (10 mg/kg, i.p.) significantly reduced the number of acetic acidinduced writhes in mice. The leaf methanol extract of R. graveolens (50 -400 mg/kg, i.p.), significantly reduced carrageenan-induced oedema over the 4 h period of testing. Combined treatment of the lowest doses of R. graveolens (25 mg/kg, i.p.) and indomethacin (2 mg/kg, i.p.) produced a significant reduction in carrageenan-induced oedema over the 4 h period of testing. R. graveolens (100 -400 mg/kg, i.p.) significantly reduced E. coliinduced pyrexia over the 5 h period of testing. Given together, the lowest dose of R. graveolens (25 mg/kg, i.p.) and pentoxifylline (10 mg/kg, i.p.) produced a significant reduction in pyrexia induced by E. coli (50 μg/kg, i.m.) over the 5 h period of measurement. The LD 50 value obtained for R. graveolens was greater than 4000mg/kg (p.o), suggesting that the plant species may be safe in or nontoxic to mice. Conclusion:The data obtained indicate that R. graveolens has antinociceptive, anti-inflammatory and antipyretic activities, justifying the use of the plant species by traditional medicine practitioners in the management and treatment of pain, inflammation and fever.Key words: Ruta graveolens, Rutaceae, antinociceptive activity, anti-inflammatory activity, Antipyretic activity, leaf methanol extract IntroductionPain, inflammation and fever are essential events that occur in response to underlying conditions such as toothache and earache, autoimmune diseases and infections. These events have been well managed and treated with the numerous effective orthodox medicines available. However, an estimated 70% of the South African population in both rural and urban areas rely on the use of plants for medicinal purposes (Light et al., 2005;Tabuti et al., 2003;Amabeoku et al., 1998). One of such plants is Ruta graveolens L. Ruta graveolens belongs to the Rutaceae family. Native to Europe and commonly grown in South Africa, it is locally known as Rue or the Herb of Grace in English, and "wynruit" or "binnewortel" in Afrikaans. R. graveolens is a woody, evergreen shrub of up to a metre in height with a characteristic aromatic scent. The plant has yellow flowers that are made up of 4 petals e...

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Phytochemistry and pharmacological properties of Ruta graveolens L.

Cited by 78 publications

References 38 publications

Herbal Medicines in Idiopathic Heavy Menstrual Bleeding: A Systematic Review

Herbal Medicines in Idiopathic Heavy Menstrual Bleeding: A Systematic Review

Apoptotic Activities of Mediterranean Plant Species

Antinociceptive, Anti-Inflammatory and Antipyretic Activities of the Leaf Methanol Extract of <i>Ruta Graveolens</i> L. (Rutaceae) in Mice and Rats

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