Phytochemistry, pharmacology and medicinal properties of Carthamus tinctorius L.

Asgarpanah, Jinous; Kazemivash, Nastaran

doi:10.1007/s11655-013-1354-5

Cited by 182 publications

(114 citation statements)

References 41 publications

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“…HSYA, molecular formula C 27 H 32 O 16 , with a molecular weight of 612, is the main component of SY. 13 SY has been used for many years in traditional Chinese medicine as a purgative, analgesic, antipyretic, and poison antidote. SY has multiple pharmacological actions such as inhibiting platelet aggregation, anticoagulation, anti-oxidation, and anti-inflammation.…”

Section: Safflower Yellow Regulates Microglial Polarization and Inhibmentioning

confidence: 99%

Safflower Yellow regulates microglial polarization and inhibits inflammatory response in LPS-stimulated Bv2 cells

Yang

Zhang

et al. 2015

Int J Immunopathol Pharmacol

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Activated microglia, especially polarized M1 cells, produce pro-inflammatory cytokines and free radicals, thereby contributing directly to neuroinflammation and various brain disorders. Given that excessive or chronic neuroinflammation within the central nervous system (CNS) exacerbates neuronal damage, molecules that modulate neuroinflammation are candidates as neuroprotective agents. In this study, we provide evidence that Safflor yellow (SY), the main active component in the traditional Chinese medicine safflower, modulates inflammatory responses by acting directly on BV2 microglia. LPS stimulated BV2 cells to upregulate expression of TLR4-Myd88 and MAPK-NF-κB signaling pathways and to release IL-1β, IL-6, TNF-α, and COX-2. However, SY treatment inhibited expression of TLR4-Myd88 and p-38/p-JNK-NF-κB, downregulated expression of iNOS, CD16/32, and IL-12, and upregulated CD206 and IL-10. In conclusion, our results demonstrate that SY exerts an anti-inflammatory effect on BV2 microglia, possibly through TLR-4/p-38/p-JNK/ NF-κB signaling pathways and the conversion of microglia from inflammatory M1 to an anti-inflammatory M2 phenotype.

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Section: Safflower Yellow Regulates Microglial Polarization and Inhibmentioning

confidence: 99%

Safflower Yellow regulates microglial polarization and inhibits inflammatory response in LPS-stimulated Bv2 cells

Yang

Zhang

et al. 2015

Int J Immunopathol Pharmacol

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“…Arachis hypogaea L. Leung et al, 1981Chang et al, 2006Asgarpanah and Kazemivash, 2013Valko et al, 2007 Tocopherols Free radical scavengers Juglans regia L. Joana et al, 2003;Li et al, 2007 Polyfunctional organic acids…”

Section: Helianthus Annuus Lmentioning

confidence: 99%

Chemical composition, antimicrobial and antioxidant properties of seed oil plants of North-East India: A review

Saha¹,

Talukdar²,

Ningthoujam³

et al. 2015

TANG [HUMANITAS MEDICINE]

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Apart from being used as food, seed oils have also been used traditionally as medicinal products by several communities. However, the full medicinal potential of many seed oil plants is yet to be properly reviewed, particularly for their antimicrobial and antioxidant properties. North-East India has rich resources of seed oil plants. The availability of detailed information on these plants is quite limited. This review aims to explore and evaluate these seed oil plants of the North-East India with particular emphasis on their antimicrobial and antioxidant activities as well as chemical compositions. A comprehensive literature search on seed oil plants of this region has been performed. Seed oil yielding plants of this region can be categorized into two categories: plants that are used traditionally as sources of edible or medicinal oils and plants that are used for purposes other than as sources of oils. Many seed oil plants of this region have been reported to possess antimicrobial and antioxidant properties, and to produce various types of compounds. This review also highlights the importance of these plants in contributing to the local as well as the national economy of India.

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“…In this study, we examined the efficacy of a number of plant extracts against Leishmania major (L. major) parasite both in vivo using infected BALB/c mice and in vitro using parasite cultures. The plant extracts were derived from Carthamus tinctorius (Family: Asteraceae) (C. tinctorius) or safflower, Pimpinella anisum (Family: Apiaceae) (P. anisum), Cuminum cyminum (Family: Apiaceae) (C. cyminum), Cinnamomum verum (Family: Lauraceae) (C. verum) and Alhagi persarum (Family: Fabaceae) (A. persarum) [10][11][12][13][14][15] . Due to its diversity of climate, Iran is home for aforementioned plants where they grow profusely.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo susceptibility of Leishmania major to some medicinal plants

Maleki

Zarebavani

Mohebali

et al. 2017

Asian Pacific Journal of Tropical Biomedicine

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Objective: To evaluate the efficacy of some medicinal plants and systemic glucantime in a comparative manner against the causative agent of cutaneous leishmaniasis both in vitro and in BALB/c mice. Methods: For in vivo testing, inbred mice were challenged with Leishmania major parasites and the resultant ulcers were treated with extract based-ointments applied topically two times per day for a period of 20 days. A group of 56 mice were randomly divided into 7 subgroups. The control group received the ointment void of extracts, whereas the reference group received glucantime only. The efficacy of treatments was evaluated by measuring ulcer diameter, parasite burden and NO production. Results: Our results indicated that plant extract based-ointments were effective in reducing ulcer size and parasite burden in spleens, but their effects did not differ significantly from that of glucantime. The plant extracts tested in this study were able to increase NO production that helped parasite suppression. Conclusions:Our findings indicate that the tested plant extracts are effective against Leishmania major both during in vitro and in vivo experiments, but further researches are required to recommend a potential plant extract as an alternative drug.

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Phytochemistry, pharmacology and medicinal properties of Carthamus tinctorius L.

Cited by 182 publications

References 41 publications

Safflower Yellow regulates microglial polarization and inhibits inflammatory response in LPS-stimulated Bv2 cells

Safflower Yellow regulates microglial polarization and inhibits inflammatory response in LPS-stimulated Bv2 cells

Chemical composition, antimicrobial and antioxidant properties of seed oil plants of North-East India: A review

In vitro and in vivo susceptibility of Leishmania major to some medicinal plants

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