Phytochemistry, Toxicity and in Vitro Antitrypanosomal Efficacy of Crude Aqueous Extract of Guiera Senegalensis Stem Bark

Biu, A. A.; Buratai, L. B.; Onyedim, P. N.; Hambali, I. U.; Ngulde, Saidu Ibrahim; Zakariah, Mohd Ihwan; Lawal, Jamila

doi:10.3329/bjvm.v14i1.28831

Cited by 4 publications

(7 citation statements)

References 9 publications

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“…Le criblage phytochimique des extraits de feuilles, de racines, de tiges et de galles a montré la présence d'hydrates de carbone, de stéroïdes, de saponines, de flavonoïdes, d'alcaloïdes, de tanins, de saponines, de glycosides cardiaques, de coumarines, d'anthraquinones, d'acide ascorbique, d'hétérosides cardiotoniques, de cyanogènes et de terpénoides (Sule et al, 2001;Lamien et al, 2005;Williams et al, 2009;Sombié et al, 2011;Somboro et al, 2011;Mamman et Isa, 2013;Salihu et Usman, 2015;Al Shafei et al, 2016;Biu et al, 2016). Mariod et al (2016) ont déterminé, selon la procédure de Folin-Ciocalteu et calculée en équivalents d'acide gallique (EAG), les teneurs en composés phénoliques totaux dans les extraits de feuilles.…”

Section: Composition Chimiqueunclassified

“…Une autre étude plus récente rapporte l'activité antitrypanosomique in vitro de l'extrait aqueux brut d'écorces de tige de G. senegalensis. L'efficacité antitrypanosomique in vitro de l'extrait a montré une inhibition de 100% de la motilité contre Trypanosoma brucei à 20 mg/ml (Biu et al, 2016).…”

Section: Activité Antiparasitaireunclassified

“…Le traitement par G. senegalensis avait entraîné une endothéliotoxicité, une hépatonephropathie et une hyperplasie pancréatique (Azza et al, 2009). Biu et al (2016) ont évalué la toxicité aiguë de l'extrait aqueux brut d'écorce de tige de G. senegalensis. 15 rats albinos des deux sexes ont été utilisés et regroupés en 5 (A à E) de 3 rats chacun.…”

Section: Toxicitéunclassified

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Revue bibliographique sur la composition chimique et les activités biologiques de Guiera senegalensis J.F. Gmel. (Combretaceae)

Tine¹,

Diop²,

Ndoye³

et al. 2020

Int. J. Bio. Chem. Sci

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Cette étude avait pour objectif de faire le point sur la composition chimique et les activités biologiques de G. senegalensis, une plante médicinale largement utilisée en Afrique par les guérisseurs traditionnels pour le traitement de divers troubles. La plupart de ces études chimiques ont porté sur le criblage phytochimique des extraits de feuilles, de racines, de tiges et de galles. Elles ont montré la présence d'hydrates de carbone, de stéroïdes, de saponines, de flavonoïdes, d’alcaloïdes, de tanins, de saponines, de glycosides cardiaques, de coumarines, d’anthraquinones, d’acide ascorbique, d’hétérosides cardiotoniques, de cyanogènes et de terpénoïdes. Les potentialités thérapeutiques des extraits de G. senegalensis rapportées dans plusieurs travaux scientifiques ont porté sur les activités antibactériennes, antitussives, antidiarrhéiques, cytotoxiques, anti-inflammatoires antipaludiques, antitrypanosomiques, antihelminthiques, antivirales et antioxydantes. Des études de toxicité sur ces extraits ont été aussi réalisées. Ainsi, des études de caractérisation chimique (variabilité chimique), de formulation galénique et aussi de toxicité clinique sur G. senegalensis doivent être menées afin de mettre en place des produits de phytothérapie moderne.Mots clés: Phytochimie, pharmacologie, feuilles, Guiera senegalensis. English Title: Review on the chemical composition and biological activities of Guiera senegalensis J.F. Gmel. (Combretaceae)The aim of this study was to review the chemical composition and biological activities of G. senegalensis, a medicinal plant widely used in Africa by traditional healers for the treatment of various disorders. Most of these chemical studies have focused on the phytochemical screening of leaf, root, stem and gall extracts. They showed the presence of carbohydrate, steroids, saponins, flavonoids, alkaloids, tannins, saponins, cardiac glycosides, coumarins, anthraquinones, ascorbic acid, cardiotonic glycosides, cyanogens and terpenoids. The therapeutic potentialities of extracts of G. senegalensis reported in several scientific studies have focused on antibacterial, antitussive, antidiarrheal, cytotoxic, anti-inflammatory, antimicrobial, antitrypanosomal, anthelmintic, antiviral and antioxidant activities. Toxicity studies on these extracts have also been carried out. Thus, chemical characterization studies (chemical variability), galenic formulation and clinical toxicity studies on G. senegalensis must be carried out in order to implement modern phytotherapy products.Keywords: Phytochemistry, pharmacology, leaves, Guiera senegalensis.

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Section: Composition Chimiqueunclassified

Section: Activité Antiparasitaireunclassified

Section: Toxicitéunclassified

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Revue bibliographique sur la composition chimique et les activités biologiques de Guiera senegalensis J.F. Gmel. (Combretaceae)

Tine¹,

Diop²,

Ndoye³

et al. 2020

Int. J. Bio. Chem. Sci

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“…studies, as shown in Table 7, to possess healing properties against many diseases [20] including cough, respiratory congestion, fever [19] bronchial disorders [13], stomach pains and dysenteric diarrhoea [21] and malaria [22]. Adapted from Alshafei et al [19] These healing properties, as reported by these studies among others, therefore prompted the present investigation into its phytochemical constituents as well its activity against malaria parasite; Plasmodium berghei Strain ANKA in Wister albino rats.…”

Section: Ijppe Volume 13mentioning

confidence: 99%

“…These natural remedies have now dominated primary health care in over 80% of the world population [8]. Guiera senegalensis, also known as "Sabara" (in the Hausa language) and "Kishishi" (in Kanuri language) has now been used in traditional medicine for the treatment of many diseases including cough, respiratory congestion and fever [9]. Aniagu et al [10] used extracts of this plant's leaves, branches, bark and roots for the treatment of stomach pains and dysentery, while its use in the treatment of syphilis, beriberi, leprosy and impotence has also been reported [11].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis of Guiera senegalensis J.F. Gmel Extract and its Anti-Plasmodial Properties on Wister Albino Mice via Oral Route

Ifijen

Mamza

Fasina

et al. 2019

IJPPE

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Guiera senegalensis J.F. Gmel (Combretaceae) is acclaimed as a common herbal antipyretic and anti-malarial among some tribal groups in northern Nigeria. The aim of this study was to investigate the phytochemical constituents, antiplasmodial activity and the acute toxicity of G. senegalensis on mammalian cells. Aqueous ethanolic leaf extracts (AELE) of the plant were tested for the presence of phytochemicals including alkaloids, carbohydrates, flavonoids, cardiac glycoside, glycosides, phenolic acids, saponins and tannins using standard techniques. The AELE was then screened for acute toxicity on Wister albino mice (WAM) weighing between 30-35g and its antiplasmodial activity against Plasmodium berghei (the causative agent of malaria in some mammals). Phytochemical screening revealed the presence of carbohydrate, phenols, flavonoids, abundant tannins, alkaloid, saponins with the absence of cardiac glycosides in the AELE. Also, it was observed that G. senegalensis extracts had no toxic effect on the WAM across administered doses of 100, 200 and 400 mg/kg. From the prophylactic study, it was found that the AELE dosage of 200 mg/kg was most effective in the inhibition of P. berghei when compared with the control than other dosages tested (100 and 200 mg/kg). The extract also exhibited a better anti-plasmodial property (80% inhibition) in the curative study compared to the standard drug (Chloroquine diphosphate) (52%), inhibiting at the graded doses of AELE. It can, therefore, be concluded from this study that G. senegalensis extract possesses essential phytochemicals, resulting in antiplasmodial effect against Plasmodium berghei.

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Review on medicinal plants and natural compounds as anti-Onchocerca agents

2018

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Onchocerciasis is a filarial vector borne disease which affects several million people mostly in Africa. The therapeutic approach of its control was based on a succession of drugs which always showed limits. The last one: ivermectin is not the least. It was shown to be only microfilaricidal and induced resistance to the human parasite Onchocerca volvulus. The approach using medicinal plants used in traditional medicine is a possible alternative method to cure onchocerciasis. Onchocerca ochengi and Onchocerca gutturosa are the parasite models used to assess anthelmintic activity of potentially anthelmintic plants. Numerous studies assessed the in vitro and/or in vivo anthelmintic activity of medicinal plants. Online electronic databases were consulted to gather publications on in vitro and in vivo studies of anti-Onchocerca activity of plants from 1990 to 2017. Globally, 13 plant families were investigated for anti-Onchocerca activity in 13 studies. The most active species were Anacardium occidentale, Euphorbia hirta and Acacia nilotica each with an LC value of 2.76, 6.25 and 1.2 μg/mL, respectively. Polycarpol, voacamine, voacangine, ellagic acid, gallic acid, gentisic acid, 3-O-acetyl aleuritolic acid and (-)-epigallocatechin 3-O-gallate were the isolated plant compounds with anti-Onchocerca activity. Most of the assessed extract/compounds showed a good safety after in vivo acute toxicity assays and/or in vitro cytotoxicity test. The exception was the ethanol extract of Trichilia emetica, which killed completely and drastically mice at a dose of 3000 mg/kg. Several plant groups of compounds were shown active against Onchocerca sp. such as tannins, alkaloids, triterpenoids and essential oils. Nevertheless, none of the active compounds was subjected to clinical trial, to assessment of its diffusibility through nodular wall or its capability to induce genetic resistance of Onchocerca sp.

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Phytochemistry, Toxicity and in Vitro Antitrypanosomal Efficacy of Crude Aqueous Extract of Guiera Senegalensis Stem Bark

Cited by 4 publications

References 9 publications

Revue bibliographique sur la composition chimique et les activités biologiques de <i>Guiera senegalensis</i> J.F. Gmel. (Combretaceae)

Revue bibliographique sur la composition chimique et les activités biologiques de <i>Guiera senegalensis</i> J.F. Gmel. (Combretaceae)

Phytochemical Analysis of <i>Guiera senegalensis</i> J.F. Gmel Extract and its Anti-Plasmodial Properties on Wister Albino Mice via Oral Route

Review on medicinal plants and natural compounds as anti-Onchocerca agents

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