Phytocompound variability, antioxidant and antibacterial activities, anatomical features of glandular and aglandular hairs of Thymus hirtus Willd. Ssp. algeriensis Boiss. and Reut. over developmental stages

Guesmi, Fatma; Saidi, Issam; Bouzenna, Hafsia; Hfaïedh, Najla; Landoulsi, Ahmed

doi:10.1016/j.sajb.2019.09.004

Cited by 19 publications

(18 citation statements)

References 28 publications

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“…Bioactivity and bioactive compounds: Some biological activities of Thymus sp. EO are directly related to the chemical composition, which can be influenced by the vegetative stage, seasonal variation of humidity, temperature, harvesting, and post-harvest factors (drying and storage) [ 199 , 206 ].…”

Section: Bioactive Compounds From Eos Of Spice Plantsmentioning

confidence: 99%

Bioactive Natural Compounds and Antioxidant Activity of Essential Oils from Spice Plants: New Findings and Potential Applications

et al. 2020

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Spice plants have a great influence on world history. For centuries, different civilizations have used them to condiment the foods of kings and nobles and applied them as embalming preservatives, perfumes, cosmetics, and medicines in different regions of the world. In general, these plants have formed the basis of traditional medicine and some of their derived substances have been utilized to treat different human diseases. Essential oils (EOs) obtained from these plants have been also used as therapeutic agents and have shown supportive uses in remedial practices. The discovery and development of bioactive compounds from these natural products, based on their traditional uses, play an important role in developing the scientific evidence of their potential pharmaceutical, cosmetic, and food applications. In the present review, using recent studies, we exhibit a general overview of the main aspects related to the importance of spice plants widely used in traditional medicine: Cinnamomum zeylanicum (true cinnamon), Mentha piperita (peppermint), Ocimum basilicum (basil), Origanum vulgare (oregano), Piper nigrum (black pepper), Rosmarinus officinalis (rosemary), and Thymus vulgaris (thyme); and we discuss new findings of the bioactive compounds obtained from their EOs, their potential applications, as well as their molecular mechanisms of action, focusing on their antioxidant activity. We also exhibit the main in vitro methods applied to determine the antioxidant activities of these natural products.

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Section: Bioactive Compounds From Eos Of Spice Plantsmentioning

confidence: 99%

Bioactive Natural Compounds and Antioxidant Activity of Essential Oils from Spice Plants: New Findings and Potential Applications

et al. 2020

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“…Thymol, (+)-epi-bicyclosesquiphellandrene, ledol, camphor, linalool, 2-carene, terpinen-4-ol, endo-borneol, eucalyptol, alpha-pinene and alloaromadendrene are found to be predominated in Thymus algeriensis . Terpenic compounds of this species were quantified from different Tunisian mountainous area [ 18 ] and over phonological stages [ 12 ]. As seen in Figure 1A , the FT-IR spectral analyses of TS volatile oil indicated the presence of aromatic groups detected at a wave number of 1650 cm -1 , carbohydrate compounds (3000 to 2800 cm -1 ), and aliphatic primary amine.…”

Section: Resultsmentioning

confidence: 99%

“…have been used as anti-inflammatory and anticancer agents and also as common tea and infusion in ethnophytotherapy [ 11 ]. The essential oil obtained from the aromatic parts of this plant has many phytotherapeutic effects and ontogenic features [ 12 ]. Thymus species has demonstrated significant free radical scavenging activity and proapoptotic effects in experimental models [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…As of now, no reports on in vivo antitumor potential of TS have been described, although few studies have characterized the presence of essential oils in the plants. This plant is a rich composition of approximately 65 bioactive compounds, including viridiflorol, 2-carene, endo-borneol, terpinen-4-ol, camphor, eucalyptol, α-pinene and linalool, which varied from 34.38 to 42.48% of the total essential oil content [ 12 ]. To evaluate its possible use as an alternative or complementary cancer treatment, this report sheds light on the potent effect of thyme essential oil on colorectal cancer cells (CRC).…”

Section: Introductionmentioning

confidence: 99%

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Thymus hirtus sp. algeriensis Boiss. and Reut. volatile oil enhances TRAIL/Apo2L induced apoptosis and inhibits colon carcinogenesis through upregulation of death receptor pathway

Guesmi

Prasad

Ali

et al. 2021

Aging

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Background: The aim of the study is to determine the anticancer activity of Thymus algeriensis (TS) and its underlying mechanisms using in vitro and in animal models. Methods: HCT116 cells were treated with TS essential oil alone or with TRAIL, and then its anticancer effect was determined by using MTT assay, live dead assay, caspase activation and PARP cleavage. Further mechanisms of its anticancer effects was determined by analyzing expression of death receptor signaling pathway using Western blotting. A mouse model was also used to assess the antitumor potential of thyme essential oil. Results: TS oily fraction showed tumor growth inhibitory effect even at lower concentration. TS induces apoptotic cell death as indicated by cleavage of PARP, and activation of the initiator and effector caspases (caspase-3, -8 and -9). Further, results showed that TS increases the expression of death receptors (DRs) and reduces the expression of TRAIL decoy receptors (DcRs). In addition, upregulation of signaling molecules of MAPK pathway (p38 kinase, ERK, JNK), down-regulation of c-FLIP, and overexpression of SP1 and CHOP were observed by TS. Further in animal model, intragastric administration of TS (12.5 mg/ml and 50 mg/ml) prevented colorectal carcinogenesis by blocking multi-steps in carcinoma. Conclusion: Overall, these results indicate that thymus essential oil promotes apoptosis in HCT116 cells and impedes tumorigenesis in animal model. Moreover, thyme potentiates TRAIL-induced cell death through upregulation of DRs, CHOP and SP1 as well as downregulation of antiapoptotic proteins in HCT116 cells. However, therapeutic potential of TS needs to be further explored.

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“…The flowers are small (5 –7 mm) and have a white purplish or pinkish purple corolla color, with the upper lip cleft and the lower one divided into three lopes ( Figure 2(b) ). Flowering and fruiting time takes place from late April to June [ 14 , 15 ].…”

Section: Botanical Description and Distributionmentioning

confidence: 99%

Unraveling the Phytochemistry, Traditional Uses, and Biological and Pharmacological Activities of Thymus algeriensis Boiss. & Reut

Mahdi

Bakrim

Bitchagno

et al. 2022

Oxidative Medicine and Cellular Longevity

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Growing concern for public health has increased the need to change the paradigm towards a healthcare system that advocates holistic practices while reducing adverse effects. Herbal therapy is becoming an integral part of the therapeutic arsenal, and several successful plant-derived compounds/molecules are being introduced into the market. The medicinal plants belonging to the genus Thymus are among the most important species within the Lamiaceae family. One of them is Thymus algeriensis which is mainly distributed in the Mediterranean region. For a long time, this species has been used in traditional medicine to treat several disorders and diseases including inflammation, diabetes, rheumatism, digestive, and respiratory affections. This review describes the traditional uses, phytochemical composition, and biological and pharmacological activities of T. algeriensis extracts. Data were obtained using electronic databases such as SciFindern, ScienceDirect, Scopus, and Web of Science. Several plant-based extracts and a broad spectrum of identified secondary metabolites were highlighted and discussed with respective activities and modes of action. T. algeriensis represents a promising natural resource for the pharmaceutical industry mainly for antioxidant, anti-inflammatory, antimicrobial, and anticancer activities. Considering these findings, more research is needed to transmute the conventional uses of T. algeriensis into scientifically sound information. Moreover, extensive preclinical, clinical, toxicological, and pharmacokinetic trials on this species and its derivatives compounds are required to underpin the mechanisms of action and ensure its biosafety and efficiency. This comprehensive review provides a scientific basis for future investigations on the use of T. algeriensis and derived compounds in health maintenance and promotion and disease prevention.

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Phytocompound variability, antioxidant and antibacterial activities, anatomical features of glandular and aglandular hairs of Thymus hirtus Willd. Ssp. algeriensis Boiss. and Reut. over developmental stages

Cited by 19 publications

References 28 publications

Bioactive Natural Compounds and Antioxidant Activity of Essential Oils from Spice Plants: New Findings and Potential Applications

Bioactive Natural Compounds and Antioxidant Activity of Essential Oils from Spice Plants: New Findings and Potential Applications

Thymus hirtus sp. algeriensis Boiss. and Reut. volatile oil enhances TRAIL/Apo2L induced apoptosis and inhibits colon carcinogenesis through upregulation of death receptor pathway

Unraveling the Phytochemistry, Traditional Uses, and Biological and Pharmacological Activities of Thymus algeriensis Boiss. & Reut

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