Phytocontact dermatitis due to Ranunculus arvensis: report of three cases

An, İsa; Uçmak, Derya; Esen, Mustafa; Gevher, Özlem Devran

doi:10.14744/nci.2018.93695

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…Ranunculus species have been commonly used in traditional medicines to treat rheumatism, intermittent fever, and rubefacient [32]. However, in some plants, like R. arvensis, R. bulbosus, R. ficaria, R. sardous, and R. sceleratus, caution must be required when using for medicinal and edible purposes, since crushing leaves produce protoanemonin, a toxic substance, which damages the skin and mucous membranes [33,34]. In this study, Rb-ME, which is a methanol extract of Ranunculus bulumei whose pharmacological activity has not been reported, did not show toxicity in macrophages, such as RAW264.7 cells and peritoneal macrophages and in mice (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Ranunculus bulumei Methanol Extract Exerts Anti-Inflammatory Activity by Targeting Src/Syk in NF-κB Signaling

2020

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1) Background: Ranunculus bulumei is a flowering plant that belongs to the Ranunculus species. Several Ranunculus species, such as R. aquatilis and R. muricatus, have traditionally been used to treat fever and rheumatism throughout Asia, suggesting that plants belonging to the Ranunculus species may have anti-inflammatory effects. To our knowledge, the pharmacological activity of R. bulumei has not been reported. Therefore, in this study, we aim to assess the anti-inflammatory activity of a methanol extract that was derived from R. bulumei (Rb-ME) in macrophage-mediated inflammatory responses and to identify the molecular mechanism that underlies any anti-inflammatory action.(2) Methods: The anti-inflammatory efficacy of Rb-ME was evaluated while using in vitro and in vivo experiments. The RAW264.7 cells and peritoneal macrophages were stimulated by lipopolysaccharide (LPS). In addition, LPS-induced peritonitis and HCl/EtOH-triggered gastritis models were produced. A nitric oxide (NO) assay, real-time PCR, luciferase reporter gene assay, western blot analysis, plasmid overexpression strategy, and in vitro kinase assay were used to determine the molecular mechanisms and target molecules of Rb-ME. The phytochemical active ingredients of Rb-ME were also identified by high performance liquid chromatograph (HPLC). (3) Results: Rb-ME reduced the production of NO and mRNA expression of iNOS, COX-2, IL-1β, and IL-6 without cytotoxicity. The protein secretion of TNF-α and IL-6 was also decreased by Rb-ME. HPLC analysis indicates that quercetin, luteolin, and kaempferol are the main active ingredients in the anti-inflammatory efficacy of Rb-ME. Rb-ME also blocked MyD88-induced NF-κB promoter activity and nuclear translocation of NF-κB subunits (p65 and p50). Moreover, Rb-ME reduced the phosphorylation of IκBα, Akt, p85, Src, and Syk, which are NF-κB upstream signaling molecules in LPS-activated RAW264.7 cells. According to the in vitro kinase assay, Rb-ME directly inhibits Syk kinase activity. The oral administration of Rb-ME alleviated inflammatory responses and the levels of p-IκBα in mice with LPS-induced peritonitis and HCl/EtOH-induced gastritis. (4) Conclusions Rb-ME has anti-inflammatory capacity by suppressing NF-κB signaling and it has been found to target Src and Syk in the NF-κB pathway. Based on this efficacy, Rb-ME could be developed as an anti-inflammatory herbal medicine.

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Section: Discussionmentioning

confidence: 99%

Ranunculus bulumei Methanol Extract Exerts Anti-Inflammatory Activity by Targeting Src/Syk in NF-κB Signaling

2020

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“…Protoanemonins are rapidly polymerized to anemonine that (they crystallized forms are harmless) are caustic poison containing two lactones. The withered or the boiled plants do not contain protoanemonins (28)(29)(30)(31)(32)(33) .…”

Section: Toxicitymentioning

confidence: 99%

Pharmacological and toxicological effects of the Ranunculus species (Ranunculus arvensis and Ranunculus sceleratus) grown in Iraq

Al-Snafi¹

2022

Int. J. Biol. Pharm. Sci. Arch.

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The current review revealed that Ranunculus arvensis contained carbohydrates, protein, amino acids, tannins, glycosides, phenols steroids, sterols, saponosides, leucoanthocyanes, di and tri terpenes, coumarins and flavanoids. It possessed antimicrobial, antioxidant and antitumor effects. Ranunculus sceleratus contained amino acid, proteins, alkaloids, phytosterols, flavonoids, steroids, fatty acid, terpenoids, phenols, saponin, tannins and resins. It exerted antibacterial, antifungal, antiviral, antiparasitic, antioxidant and anti-inflammatory effects. However both species were not free from adverse effects.

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“…Moreover, R. arvensis extracts showed antioxidant and anticarcinogenic activities [49,62]. However, topical use of the plant may cause contact dermatitis, such as skin inflammation, skin burns, and injury of mucous membranes [80][81][82].…”

Section: Ranunculus Arvensis Linnmentioning

confidence: 99%

Therapeutic Potential of Ranunculus Species (Ranunculaceae): A Literature Review on Traditional Medicinal Herbs

Goo

2022

Plants

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The genus Ranunculus includes approximately 600 species and is distributed worldwide. To date, several researchers have investigated the chemical and biological activities of Ranunculus species, and my research team has found them to have antimalarial effects. This review is based on the available information on the traditional uses and pharmacological studies of Ranunculus species. The present paper covers online literature, particularly from 2010 to 2021, and books on the ethnopharmacology and botany of Ranunculus species. Previous studies on the biological activity of crude or purified compounds from Ranunculus species, including R. sceleratus Linn., R. japonicus Thunb., R. muricatus Linn., R. ternatus Thunb., R. arvensis Linn., R. diffusus DC., R. sardous Crantz, R. ficaria Linn., R. hyperboreus Rotlb., and R. pedatus Waldst. & Kit., have provided new insights into their activities, such as antibacterial and antiprotozoal effects as well as antioxidant, immunomodulatory, and anticarcinogenic properties. In addition, the anti-inflammatory and analgesic effects of plants used in traditional medicine applications have been confirmed. Therefore, there is a need for more diverse studies on the chemical and pharmacological activities of highly purified molecules from Ranunculus species extracts to understand the mechanisms underlying their activities and identify novel drug candidates.

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Phytocontact dermatitis due to Ranunculus arvensis: report of three cases

Cited by 4 publications

References 7 publications

Ranunculus bulumei Methanol Extract Exerts Anti-Inflammatory Activity by Targeting Src/Syk in NF-κB Signaling

Ranunculus bulumei Methanol Extract Exerts Anti-Inflammatory Activity by Targeting Src/Syk in NF-κB Signaling

Pharmacological and toxicological effects of the Ranunculus species (Ranunculus arvensis and Ranunculus sceleratus) grown in Iraq

Therapeutic Potential of Ranunculus Species (Ranunculaceae): A Literature Review on Traditional Medicinal Herbs

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