2007
DOI: 10.2217/14796694.3.3.307
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Phytoestrogens: Perpetrators Or Protectors?

Abstract: Phytoestrogens are estrogen-like substances produced by plants that account for some of the constituents present in vegetation that may be responsible for the health benefits of a diet rich in fruit and vegetables. Phytoestrogens have a plethora of different actions that they are capable of exerting on cellular metabolism. This review will focus on some of the major non-estrogen receptor-mediated cellular effects used by phytoestrogens and will draw attention to the fact that while they may have a number of be… Show more

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Cited by 25 publications
(16 citation statements)
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“…Moreover, isoflavones may provide an alternative to hormone replacement therapy in clinical treatments of osteoporosis and other post-menopausal symptoms (Vatanparast and Chilibeck, 2007). Likewise, the estrogenic effects of isoflavones show promise in many animal models as chemo-preventive agents for hormone-related cancers of the breast, prostate and colon (Martin et al, 2007).…”
Section: Isoflavones: Synthesis Function and Soymentioning
confidence: 99%
“…Moreover, isoflavones may provide an alternative to hormone replacement therapy in clinical treatments of osteoporosis and other post-menopausal symptoms (Vatanparast and Chilibeck, 2007). Likewise, the estrogenic effects of isoflavones show promise in many animal models as chemo-preventive agents for hormone-related cancers of the breast, prostate and colon (Martin et al, 2007).…”
Section: Isoflavones: Synthesis Function and Soymentioning
confidence: 99%
“…Soybeans contain approximately 670 mg genistein and 540 mg daidzein per kilogram (Franke et al, 1994). As the predominant isoflavone of soy, genistein has received more attention, reported to possess antioxidant and antiangiogenic properties and to inhibit protein tyrosine kinases (reviewed in Martin et al, 2007). So more recent studies gradually began to investigate mechanisms of action and possible health benefits of daidzein.…”
Section: Introductionmentioning
confidence: 99%
“…Both beneficial and unfavorable effects were observed and discussed for phytoestrogens (Martin et al, 2007), and what makes such discussions urgent is that no one is able to predict or control the effects. Bidirectional regulation of phytoestrogens, i.e., pro-angiogenic/protective against cardiovascular diseases and anti-angiogenic/preventive against cancer, has been reported with occasionally controversial findings .…”
Section: Applications Of Estrogenic Activity Of Tcmmentioning
confidence: 99%