Phytosterols on growth performance, antioxidant enzymes and intestinal morphology in weaned piglets

Hu, Qiaoling; Li, Sisi; Zhang, Yiwei; Zhao, Zhuo; Feng, Jie

doi:10.1002/jsfa.8333

Cited by 25 publications

(18 citation statements)

References 46 publications

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“…These findings could, at least partially, explain the improved growth performance of broilers receiving β-sitosterol in the current study. However, controversial results on growth performance as an effect of phytosterols supplementation have also been observed in broilers [13], laying hens [15], and weaned piglets [11]. The discrepancies may be related with dosage and composition of phytosterols, but also species, environment, feeding management, etc.…”

Section: Discussionmentioning

confidence: 99%

“…Phytosterols are plant-derived natural steroid compounds, and mainly contain β-sitosterol, stigmasterol, campesterol, and brassicasterol. The effects of phytosterols’ application on livestock production have been recently investigated [11,12,13,14,15,16]. However, due to their mixed compositions, it is difficult to explain their mode of action and their physiological functions.…”

Section: Introductionmentioning

confidence: 99%

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Dietary β-Sitosterol Improves Growth Performance, Meat Quality, Antioxidant Status, and Mitochondrial Biogenesis of Breast Muscle in Broilers

Cheng¹,

Chen²,

Li³

et al. 2019

Animals

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The present study evaluated effects of β-sitosterol on growth performance, meat quality, oxidative status, and mitochondrial biogenesis of breast muscle in broilers. One-day-old chicks were allocated to five treatments of six replicates. Broilers were fed a basal diet supplemented either with 0 (control), 40, 60, 80, or 100 mg/kg β-sitosterol for 42 days. β-sitosterol linearly and quadratically reduced feed/gain ratio, lightness24h and cooking loss24h in breast muscle, whereas 2, 2-diphenyl-1-picrylhydrazyl scavenging activity of breast muscle followed an opposite trend. β-sitosterol linearly decreased drip loss24h and malondialdehyde content, whereas linearly increased pH24h, superoxide dismutase activity, and mRNA abundances of peroxisome proliferator-activated receptor γ coactivator 1α (PCG-1α) and mitochondrial transcription factor A (TFAM) in breast muscle. Compared with control, levels of β-sitosterol higher than 40 mg/kg reduced feed/gain ratio, muscular lightness24h, cooking loss24h, and malondialdehyde level, whereas increased muscular 2, 2-diphenyl-1-picrylhydrazyl scavenging activity, and mRNA abundances (except 60 mg/kg) of PCG-1α and TFAM. Eighty milligram/kilogram β-sitosterol increased muscular pH24h and superoxide dismutase activity, but decreased its drip loss24h. Therefore, β-sitosterol could improve growth performance and meat quality, oxidative status, and mitochondrial biogenesis of breast muscle in broilers. Furthermore, supplementation level of 80 mg/kg β-sitosterol is recommended for broiler diets.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary β-Sitosterol Improves Growth Performance, Meat Quality, Antioxidant Status, and Mitochondrial Biogenesis of Breast Muscle in Broilers

Cheng¹,

Chen²,

Li³

et al. 2019

Animals

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“…Moreover, a main component of PS (β-sitosterol) has been demonstrated to not only inhibit the production of tumor necrosis factor α, interleukin-1β, and interleukin-6 in RAW 264.7 mouse macrophages under immune stress but can also efficiently ameliorate the depletion of glutathione and reduce antioxidant enzymes, including superoxide dismutase and glutathione peroxidase, in the colonic and hepatic tissues of rats induced by 1,2-dimethylhydrazine ( Baskar et al., 2012 ; Choi et al., 2012 ). In addition, the integrity of intestinal mucosa morphology is the basis of maintaining normal intestinal physiological activity in animals, improvement on gut morphology of weaned pigs fed PS has been shown by Hu et al. (2017) .…”

Section: Introductionmentioning

confidence: 99%

Effects of phytosterol supplementation on growth performance, serum lipid, proinflammatory cytokines, intestinal morphology, and meat quality of white feather broilers

et al. 2021

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The aim of this study was to evaluate the effects of dietary phytosterol ( PS ) addition at different levels on growth performance, serum lipid, proinflammatory cytokines, intestinal morphology, and meat quality in broilers. A total of 600, 1-day-old male broilers were allocated into five groups with six replicates and were fed a basal diet supplemented with 0 (control group), 10, 20, 40, or 80 mg/kg PS for 42 days. Compared with the control group, the administration of PS at doses of 40 and 80 mg/kg significantly increased the average daily feed intake and average daily gain of broilers during the experimental period. Similarly, PS at a dosage of 20 and 40 mg/kg increased the concentrations of interleukin-1β, interferon-γ, interleukin-2, and interleukin-6 but decreased triglyceride, total cholesterol, and low-density lipoprotein cholesterol content of serum ( P < 0.05). Dietary PS at less than or equal to 40 mg/kg level increased ( P < 0.05) villus height, and villus height to crypt depth ratio in the duodenum and ileum. Supplementing PS increased the pH value at 45 min post-mortem and decreased drip loss and shear force of breast muscle ( P < 0.05). Dietary PS administration at 20 and 40 mg/kg decreased malondialdehyde accumulation but increased total antioxidant capacity and superoxide dismutase activity of breast muscle compared with the control group ( P < 0.05). PS increased the concentrations of total amino acids and flavor amino acids as well as eicosapentaenoic acid, docosahexaenoic acid, and total polyunsaturated fatty acids but decreased saturated fatty acids in breast muscle ( P < 0.05). It was concluded that dietary PS supplementation, especially at 40 mg/kg, could improve growth performance, serum lipid, proinflammatory cytokines, intestinal morphology, and meat quality in broilers, providing insights into its application as a potential feed additive in broiler production.

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“…Plant extracts have been studied as alternative feed additives and were reported as good source of natural antioxidant to improve animal production and health status ( Hu et al., 2017 ). However, plant extract contains higher amount of polyunsaturated fatty acids that may lead to oxidative stress in chickens ( Gao et al., 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of chestnut wood extract on performance, meat quality, antioxidant status, immune function, and cholesterol metabolism in broilers

Liu

Mahfuz

et al. 2020

Poultry Science

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Plant extracts have been proved as natural antioxidants resources as well as alternative feed additives in livestock and poultry species. Chestnut wood extract ( CWE ) as a source of hydrolysable tannic acid was used to evaluate the growth performance, nutrient retention, meat quality, antioxidant status, and immune function of broilers. A total of 168, day-old Arbor Acre male broilers (weight 46.59 ± 0.44 g) were randomly divided to 3 treatments, 7 replicate pens per treatment, 8 broilers per pen. The treatments contain a control diet, CON (corn-soybean meal basal diet); an antibiotic diet, CTC (basal diet + 75 mg/kg chlortetracycline); and chestnut wood extract diet, CWE (basal diet + 1,000 mg/kg chestnut tannins). At the finisher phase, final body weight was higher ( P < 0.05) in CWE supplemented diet than in CON. Average daily body weight gain was higher ( P < 0.05) and feed gain ratio was lower ( P < 0.05) in broilers fed CWE than in those fed CON at the finisher phase. Crude protein digestibility was higher ( P < 0.05) in broilers offered CWE than that in broilers fed CON and CTC diets. Breast muscle pH value at 24 h (pH 24 h ) was higher ( P < 0.05) in broilers fed CWE than that in those fed CON and CTC diets. The bursa weight was higher ( P < 0.05) in broilers offered CWE than that in those fed CON and CTC. Total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) values were higher ( P < 0.05) in both breast muscle and thigh muscle of broilers offered CWE supplemented diet than those in broilers fed CON and CTC diets. Similarly, broilers offered with CWE diets showed higher ( P < 0.05) T-AOC, GSH-PX, and SOD value in serum than those fed CON and CTC diets. Serum concentration of IgG was higher ( P < 0.05) in broilers offered with CWE diets than that in those fed CON and CTC diets. Total cholesterol, low-density lipoprotein cholesterol, and urea-N concentration were lower ( P < 0.05) in broilers offered CWE diet than those in broilers fed CON and CTC diets. It was recommended to supply CWE at the 1,000 mg/kg level for improving antioxidant status, cholesterol metabolism, and growth performance without affecting normal meat quality in broilers.

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Phytosterols on growth performance, antioxidant enzymes and intestinal morphology in weaned piglets

Cited by 25 publications

References 46 publications

Dietary β-Sitosterol Improves Growth Performance, Meat Quality, Antioxidant Status, and Mitochondrial Biogenesis of Breast Muscle in Broilers

Dietary β-Sitosterol Improves Growth Performance, Meat Quality, Antioxidant Status, and Mitochondrial Biogenesis of Breast Muscle in Broilers

Effects of phytosterol supplementation on growth performance, serum lipid, proinflammatory cytokines, intestinal morphology, and meat quality of white feather broilers

Effect of chestnut wood extract on performance, meat quality, antioxidant status, immune function, and cholesterol metabolism in broilers

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