Phα1β is a Promising Neuroprotective Peptide from the Phoneutria nigriventer ‘Armed’ Spider

Antunes, Flavia Tasmin Techera; Caminski, Emanuelle Sistherenn; Gomez, Marcus V.; Souza, Alessandra Hübner de

doi:10.1007/s10989-022-10381-6

Cited by 2 publications

(1 citation statement)

References 62 publications

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“…Under that scenario, current studies using animal venom toxins, particularly from the Phoneutria nigriventer spider, have shown higher interest in neurodegenerative disorders like HD ( Antunes et al, 2022 ). CTK 01512-2, the recombinant peptide from the Tx3-6 native isoform, the NTCCs blocker, is displayed to improve the BACHD animal’s motor force, and the locomotor performance when delivered intrastriatal ( Joviano-Santos et al, 2021 ), or intrathecal ( Joviano-Santos et al, 2022 ) by inhibiting the neuronal apoptosis with a site-specific effect.…”

Section: Introduction: Neuronal Aspects Of Calcium Signalingmentioning

confidence: 99%

Targeting N-type calcium channels in young-onset of some neurological diseases

Antunes

Souza

Figueira

et al. 2022

Front. Cell Dev. Biol.

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Graphical AbstractN-type calcium channels dysregulation and neurotransmission impairment Early-onset of neurological conditions, like Huntington’s disease, Multiple Sclerosis, and Migraine demonstrate harmful processes, such as neuroinflammation, neurodegeneration, and conditions like pain. N-type voltage-gated calcium channels are responsible for the exacerbated calcium influx that triggers neurotransmitter release.

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Section: Introduction: Neuronal Aspects Of Calcium Signalingmentioning

confidence: 99%

Targeting N-type calcium channels in young-onset of some neurological diseases

Antunes

Souza

Figueira

et al. 2022

Front. Cell Dev. Biol.

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Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain

Antunes

Campos

Carvalho³

et al. 2023

IJMS

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Voltage-gated calcium channels (VGCCs) are targeted to treat pain conditions. Since the discovery of their relation to pain processing control, they are investigated to find new strategies for better pain control. This review provides an overview of naturally based and synthetic VGCC blockers, highlighting new evidence on the development of drugs focusing on the VGCC subtypes as well as mixed targets with pre-clinical and clinical analgesic effects.

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Phα1β is a Promising Neuroprotective Peptide from the Phoneutria nigriventer ‘Armed’ Spider

Cited by 2 publications

References 62 publications

Targeting N-type calcium channels in young-onset of some neurological diseases

Targeting N-type calcium channels in young-onset of some neurological diseases

Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain

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