Pial collaterals develop through mosaic colonization of capillaries by arterial and microvascular endothelial cells
Tijana Perovic,
Irene Hollfinger,
Stefanie Mayer
et al.
Abstract:Collaterals are unique blood vessels present in many healthy tissues that cross-connect distal-end arterioles of adjacent arterial trees, thus providing alternate routes of perfusion. Stroke patients with superior pial collateral flow respond better to treatments and present with an overall improved prognostic outcome. However, how pial collaterals develop in the embryo and how they reactivate upon stroke remains unclear. Here, using lineage tracing in combination with three-dimensional imaging, we demonstrate… Show more
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