Analysis 2.3. Comparison 2 Macrolide versus penicillin, Outcome 3 Sore throat post-treatment (ITT analysis).. . Analysis 2.4. Comparison 2 Macrolide versus penicillin, Outcome 4 Fever post-treatment (ITT analysis).. .. . Analysis 2.5. Comparison 2 Macrolide versus penicillin, Outcome 5 Incidence of relapse (evaluable participants).. . Analysis 2.6. Comparison 2 Macrolide versus penicillin, Outcome 6 Adverse events (ITT analysis).. .. .. . Analysis 2.7. Comparison 2 Macrolide versus penicillin, Outcome 7 Resolution of symptoms ITT (subgroup sponsored versus no-sponsor reported