Pickering emulsions stabilized with cashew gum nanoparticles as indomethacin carrier

Cardial, Mayrla R. Lima; Paula, Haroldo C.B.; Silva, Rudson Brendon Cordeiro da; Barros, João Felipe da Silva; Richter, Ana Rosa; Sombra, Fernanda M.; Paula, Regina C.M. de

doi:10.1016/j.ijbiomac.2019.03.198

Cited by 24 publications

(8 citation statements)

References 39 publications

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“…The loaded nanoparticles of particle sizes between 23 nm and 1.5 mm showed biocompatibility when evaluated in OSCC cell lines, demonstrating that cashew gum may be a promising polysaccharide to develop delivery systems for anti-inflammatory drugs. Pickering emulsions were also used by Lima Cardial et al ( 2019) [80] in the development of nanoparticles containing acetylated derivatives of cashew gum, with the aim of loading indomethacin. The CG nanoparticles carrying the drug showed particle size and zeta potential influenced by the different degrees of acetylation of the polysaccharide, presenting an encapsulation efficiency of about 50% for indomethacin.…”

Section: Gomez Et Al (2016)mentioning

confidence: 99%

“…The patents related to the use of cashew gum and its applications are presented in Table 3. Pickering emulsions were also used by Lima Cardial et al ( 2019) [80] in the development of nanoparticles containing acetylated derivatives of cashew gum, with the aim of loading indomethacin. The CG nanoparticles carrying the drug showed particle size and zeta potential influenced by the different degrees of acetylation of the polysaccharide, presenting an encapsulation efficiency of about 50% for indomethacin.…”

Section: Cashew Gum Patent Perspectives In Brazilmentioning

confidence: 99%

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Cashew Gum: A Review of Brazilian Patents and Pharmaceutical Applications with a Special Focus on Nanoparticles

Amaral

Andrade

et al. 2022

Micromachines

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Natural polysaccharides are structures composed of highly diversified biological macromolecules whose properties have been exploited by a diversity of industries. Until 2018, the polysaccharides market raised more than US $ 12 billion worldwide, while an annual growth forecast of 4.8% is expected by 2026. The food industry is largely responsible for the consumption of this plant-source material, produced by microbiological fermentation. Among the used polysaccharides, gums are hydrocolloids obtained from a variety of sources and in different forms, being composed of salts of calcium, potassium, magnesium and sugar monomers. Their non-toxicity, hydrophilicity, viscosity, biodegradability, biocompatibility and sustainable production are among their main advantages. Although Brazil is amongst the largest producers of cashew gum, reaching 50 tons per year, the polysaccharide is not being used to its full potential, in particular, with regard to its uses in pharmaceuticals. Cashew gum (CG), obtained from Anacardium occidentale L., caught the attention of the industry only in 1970; in 1990, its production started to grow. Within the Brazilian academy, the groups from the Federal University of Ceará and Piauí are devoting the most efforts to the study of cashew gum, with a total of 31 articles already published. The number of patents in the country for innovations containing cashew tree gum has reached 14, including the technological process for the purification of cashew tree gum, comparison of physical and chemical methods for physicochemical characterizations, and optimum purification methodology. This scenario opens a range of opportunities for the use of cashew gum, mainly in the development of new pharmaceutical products, with a special interest in nanoparticles.

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Section: Gomez Et Al (2016)mentioning

confidence: 99%

Section: Cashew Gum Patent Perspectives In Brazilmentioning

confidence: 99%

Cashew Gum: A Review of Brazilian Patents and Pharmaceutical Applications with a Special Focus on Nanoparticles

Amaral

Andrade

et al. 2022

Micromachines

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“…The presence of available groups of glucuronic acids and hydroxyls in its framework, even in small percentages, adds a negative surface charge to the material, making it possible to carry out reactions with different polymers through different molecular interactions [9]. CG shows promising properties to be used in the formation of layer-by-layer films applied to nanobiomedical devices [10], as Pickering emulsions stabilizers [11], in aceclofenac toothpastes [12] and also showing antinociceptive and anti-inflammatory activity [13].…”

Section: Introductionmentioning

confidence: 99%

The Potential Role of Polyelectrolyte Complex Nanoparticles Based on Cashew Gum, Tripolyphosphate and Chitosan for the Loading of Insulin

et al. 2021

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Polyelectrolytic complexation has stood out due to its application in the development of drug delivery systems using biopolymers as raw materials. The formation of complexes between cashew gum and chitosan can be intermediated by cross-links, mediated by the action of the sodium tripolyphosphate crosslinking agent. These polymers have been used in the nanotechnological development of formulations to protect peptide drugs, such as insulin, allowing their oral administration. In this work, we describe the development of polyelectrolytic complexes from cashew gum and chitosan as biopolymers for oral administration of insulin. The obtained complexes showed a mean particle size of 234 nm and polydispersity index of 0.2. The complexes were 234 nm in size, PDI 0.2, zeta potential −4.5 mV and 22% trapping. The obtained complexes demonstrated considerable and promising characteristics for use as oral insulin delivery systems.

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“…The use of Pickering emulsions as vehicles of hydrophobic drugs has been recently studied aiming at enhancing the absorption and bioavailability of the active agents [19,20]. In what concerns resveratrol, the examples involving the use of Pickering emulsions are scarce.…”

Section: Introductionmentioning

confidence: 99%

Enhancing trans-resveratrol topical delivery and photostability through entrapment in chitosan/gum Arabic Pickering emulsions

Sharkawy

Casimiro

Barreiro

et al. 2020

International Journal of Biological Macromolecules

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The surfactant-free nature and higher stability of Pickering emulsions make them preferable solutions over conventional emulsions for skin applications. In this work, Pickering emulsions stabilized by chitosan/gum Arabic (CH/GA) nanoparticles were tested as vehicles for trans-resveratrol topical delivery. Skin absorption was examined ex vivo using Franz diffusion cells and porcine skin. Pickering emulsions allowed higher cutaneous retention and lower permeation of resveratrol, in comparison with a control solution based on a 20% v/v ethanol. The total amount of resveratrol retained in the skin, 24 h after the application, was 11.60% and 10.82% of the applied dose for the tested Pickering emulsion-based formulations prepared with 0.5% and 1.5% w/v CH/GA nanoparticles, respectively. In contrast, resveratrol skin retention from the control solution was only 2.86%. Confocal laser scanning microscopy revealed enhanced skin deposition of Nile Red to deeper layers from the Pickering emulsionbased formulations. Moreover, Pickering emulsions led to trans-resveratrol photostability increase, as measured after exposure to UV for 4 h. These results show that the CH/GA Pickering emulsions are promising solutions for the topical delivery of trans-resveratrol and have the potential to be used as green cosmetic products.

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Pickering emulsions stabilized with cashew gum nanoparticles as indomethacin carrier

Cited by 24 publications

References 39 publications

Cashew Gum: A Review of Brazilian Patents and Pharmaceutical Applications with a Special Focus on Nanoparticles

Cashew Gum: A Review of Brazilian Patents and Pharmaceutical Applications with a Special Focus on Nanoparticles

The Potential Role of Polyelectrolyte Complex Nanoparticles Based on Cashew Gum, Tripolyphosphate and Chitosan for the Loading of Insulin

Enhancing trans-resveratrol topical delivery and photostability through entrapment in chitosan/gum Arabic Pickering emulsions

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