Picosecond laser for atrophic surgical scars treatment: <i>in vivo</i> monitoring of results by means of reflectance confocal microscopy

Guida, Stefania; Bencini, Pier Luca; Pellacani, Giovanni

doi:10.1111/jdv.15289

Cited by 15 publications

(39 citation statements)

References 9 publications

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“…Spot size area was 8 mm, containing 60 focused microdots, the distance between each microdots is 1 mm (dots pitch). The fluence delivered for each 8 mm spot was 1.2 ± 0.2 J/cmq, corresponding to an energy level of mJ 10 for each microdot …”

Section: Methodsmentioning

confidence: 99%

“…No topical anesthesia was used prior to laser treatment. The entire targeted scarred area treatment protocol has been previously described . Three laser passes were administered sequentially in rows, by delivering pulses in a painting mode to reach a total dot density of 180 dots cmq, approximatively corresponding to 15% surface of micro‐injured skin.…”

Section: Methodsmentioning

confidence: 99%

“…One VivaStack (Lucid) (0.5 × 0.5 mm lateral resolution) with a step of 2 μm up to 100 μm in depth was imaged to measure the epidermal thickness. Previously identified confocal parameters of skin scars were described . Two blinded investigators evaluated RCM images.…”

Section: Methodsmentioning

confidence: 99%

“…First applications in Dermatology have been represented by optimizing tattoo removal, followed by skin rejuvenation . A growing interest in the treatment of scars with PSL is evident for atrophic and hypertrophic scars, that have been shown to improve clinically . Interestingly, in vivo noninvasive imaging analysis has been shown to provide new insights into underlying mechanisms of improvement for atrophic scars …”

Section: Introductionmentioning

confidence: 99%

“…The aim of this study is to apply PSL system to atrophic and hypertrophic surgical scars and to report in vivo architecture of scars and variations occurring before and after treatment. In this study, 3D optical tool assessment of skin surfaces, hemoglobin and melanin concentration and distribution, as well as reflectance confocal microscopy (RCM), enabling evaluation of the skin at a quasi ‐histological resolution and providing in vivo information about epidermal, dermo‐epidermal junction (DEJ), and dermal features, were employed to explore the effects of PSL.…”

Section: Introductionmentioning

confidence: 99%

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Picosecond laser treatment of atrophic and hypertrophic surgical scars: In vivo monitoring of results by means of 3D imaging and reflectance confocal microscopy

Guida

Pellacani

Bencini³

2019

Skin Res Technol

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Purpose A growing interest in the treatment of scars with picosecond laser (PSL) is evident, although the basis for scar improvement is poorly understood. The aim is to provide new insights into the role of PSL in scar improvement through noninvasive in vivo skin imaging. Methods A total of 16 patients with 20 surgical scars were treated with three sessions of PSL. Efficacy was estimated through blinded evaluations performed by external dermatologists, Vancouver Scar Scale (VSS), Global Assessment Improvement Scale (GAIS), patient satisfaction, 3D imaging, and reflectance confocal microscopy (RCM) assessments at T0 (before treatment) and at T1 (6 months post‐treatment). Safety was estimated through adverse events evaluation. Results In vivo findings revealed the modulation of pigmentation, vascularization, improved texture (P = .0001; 3D imaging), and variations of collagen remodeling (at RCM) in both atrophic and hypertrophic scars. A reduced epidermal thickness (at RCM) was observed in hypertrophic scars (P < .01) after treatment. Conclusions Our results confirm that PSL is an effective and safe technique for the treatment of atrophic and hypertrophic scars. In detail, we describe herein 3D and RCM features enabling the visualization of variations occurring in the skin after PSL treatment.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Picosecond laser treatment of atrophic and hypertrophic surgical scars: In vivo monitoring of results by means of 3D imaging and reflectance confocal microscopy

Guida

Pellacani

Bencini³

2019

Skin Res Technol

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Efficacy and Safety of Ablative Resurfacing With A High‐Energy 1,064 Nd‐YAG Picosecond‐domain Laser for the Treatment of Facial Acne Scars in Asians

Dai

Chuang²,

Chen

et al. 2019

Lasers Surg Med

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Objectives There have been few studies regarding the use of a picosecond‐domain laser for acne scars in Asians. This prospective study evaluated the efficacy and safety of a high‐energy 1,064 nm Nd:YAG picosecond‐domain laser for ablation and resurfacing of facial acne scars in Asians. Methods Subjects were treated with a 1,064 nm picosecond laser (8 mm spot, 0.7–1.0 J/cm2, 5 Hz) every 4 weeks for three sessions. Two blinded dermatologists evaluated the pre‐ and 3‐month post‐treatment images with a 10‐point improvement scale. Subject pain, global improvement, and satisfaction were also assessed. The Facial Acne Scar Quality of Life (FASQoL) questionnaire was used to evaluate the subjects’ quality of life. Results Twenty subjects aged 18–50 years with Fitzpatrick skin type III–V were enrolled. The median dermatologist‐rated improvement score was 3 out of 10. Subjects were satisfied to very satisfied with global improvement. Subjects’ quality of life significantly improved with a median FASQoL score of 10 after treatment compared with 21 before treatment (P < 0.001). Adverse effects were limited to erythema, pain, and edema without postinflammatory hyperpigmentation. Conclusions The 1,064 nm picosecond‐domain laser with ablative resurfacing parameters is safe and effective for the treatment of acne scars in Asians. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

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A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations

et al. 2020

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Background and Objectives The use of picosecond laser in dermatology was originally focused on optimizing the removal of unwanted tattoos. Subsequent advances in this technology have broadened its clinical indications to include treatment of benign pigmented lesions, photodamage, melasma, and scar revision. In this systematic review, evidence‐based recommendations are developed for the use of picosecond laser in dermatology. Study Design/Materials and Methods A comprehensive search of the English language literature was performed up to and including November 2019. Relevant citations were individually evaluated, synthesized, and categorized based on the Level of Evidence. With the addition of the authors’ combined clinical experience, clinical recommendations were developed. Results After application of inclusion and exclusion criteria, a total of 77 unique studies were evaluated. Treatment of benign pigmented lesions was associated with level I–IV evidence; rejuvenation was associated with level II evidence; melasma was associated with level II evidence; scar revision was associated with level II–III evidence; tattoo removal was associated with level I evidence. Conclusion Picosecond laser is a safe and effective treatment modality for an increasing range of dermatologic indications. Further development of this technology is warranted. Lasers Surg. Med. © 2020 Wiley Periodicals, Inc.

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Picosecond laser for atrophic surgical scars treatment: in vivo monitoring of results by means of reflectance confocal microscopy

Cited by 15 publications

References 9 publications

Picosecond laser treatment of atrophic and hypertrophic surgical scars: In vivo monitoring of results by means of 3D imaging and reflectance confocal microscopy

Picosecond laser treatment of atrophic and hypertrophic surgical scars: In vivo monitoring of results by means of 3D imaging and reflectance confocal microscopy

Efficacy and Safety of Ablative Resurfacing With A High‐Energy 1,064 Nd‐YAG Picosecond‐domain Laser for the Treatment of Facial Acne Scars in Asians

A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations

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